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• W321592570 abstract "Manganese (Mn2+)-enhanced MRI (MEMRI) is a valuable imaging tool to study brain structure and function in normal and diseased small animals. The brain retention of Mn2+ is relatively long with a half-life (t1/2) of 51–74 days causing a slow decline of MRI signal enhancement following Mn2+ administration. Such slow decline limits using repeated MEMRI to follow the central nervous system longitudinally in weeks or months. This is because residual Mn2+ from preceding administrations can confound the interpretation of imaging results. We investigated whether the Mn2+ enhancement decline could be accelerated thus enabling repeated MEMRI, and as a consequence broadens the utility of MEMRI tests. We investigated whether N-acetyl-para-aminosalicylic acid (AcPAS), a chelator of Mn2+, could affect the decline of Mn2+ induced MRI enhancement in brain. Two-week treatment with AcPAS (200 mg/kg/dose × 3 daily) accelerated the decline of Mn2+ induced enhancement in MRI. In the whole brain on average the enhancement declined from 100% to 17% in AcPAS treated mice, while in PBS controls the decline is from 100% to 27%. We posit that AcPAS could enhance MEMRI utility for evaluating brain biology in small animals. To the best of our knowledge, no method exists to accelerate the decline of the Mn2+ induced MRI enhancement for repeated MEMRI tests." @default.
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• W321592570 date "2015-08-01" @default.
• W321592570 modified "2023-10-16" @default.
• W321592570 title "Potential of N-acetylated-para-aminosalicylic acid to accelerate manganese enhancement decline for long-term MEMRI in rodent brain" @default.
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• W321592570 doi "https://doi.org/10.1016/j.jneumeth.2015.05.013" @default.
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