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- W3216014804 endingPage "512" @default.
- W3216014804 startingPage "471" @default.
- W3216014804 abstract "Circulating tumor DNAs (ctDNAs) are acellular fragments of tumor-derived DNA that have been shed by cancer cells into the bloodstream via secretion, apoptosis, and necrosis. In cancer patients, these ctDNAs join the pool of circulating cell-free DNA (cfDNA) shed by dying normal cells to form a fraction of the total cfDNA content in blood plasma. CtDNAs retain the genetic mutational spectrum and DNA methylation profiles of the originating tumor, thereby providing a source of blood-based biomarkers for cancer detection and for monitoring cancer activity over time. Various ctDNA detection, quantification, and profiling technologies have been applied across multiple cancer settings, including population-based screening for cancer detection, “liquid biopsy” of tumors that are inaccessible to repeat tissue-based biopsy, measures of response to treatment, and the detection of molecular residual disease or relapse in patients undergoing treatment, to name a few. DNA loci that are frequently and specifically differentially methylated in particular cancer types provide advantageous biomarkers, particularly as applied to population-based screening, because they allow for cheap targeted tests for the detection of individual cancer types, as well as broader ctDNA profiling to detect and locate the tissue-of-origin of cancer where this is unknown. The methylated SEPTIN9 biomarker now serves as a clinically approved ctDNA-based real-time PCR test for the detection of colorectal cancer. The Galleri test by GRAIL, Inc., which is based on broader next-generation bisulfite sequencing, is poised for implementation as a multi-cancer detection test to both detect and locate cancers that are frequent in the population or for which no population-based clinical screening test is available." @default.
- W3216014804 created "2021-12-06" @default.
- W3216014804 creator A5083863816 @default.
- W3216014804 date "2022-01-01" @default.
- W3216014804 modified "2023-09-27" @default.
- W3216014804 title "Methylated circulating tumor DNA biomarkers for the blood-based detection of cancer signals" @default.
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