Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216014937> ?p ?o ?g. }
- W3216014937 abstract "Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses to immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering the feasibility of sample collection, whether peripheral B cell signatures are associated with the responses to ICI therapy remains unclear. Herein, we have defined peripheral B cell signatures in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-1 monotherapy and investigated their associations with clinical efficacy. It was found that the percentages of B cells before the treatment (baseline) were significantly higher (P = 0.004) in responder (R, n = 17) than those in non-responder (NonR, n = 33) NSCLC patients in a discovery cohort. Moreover, the percentages of baseline IgM+ memory B cells were higher (P < 0.001) in R group than those in NonR group, and associated with a longer progression free survival (PFS) (P = 0.003). By logistic regression analysis peripheral baseline IgM+ memory B cells were identified as an independent prognostic factor (P = 0.002) for the prediction of the responses to anti-PD-1 monotherapy with the AUC value of 0.791, which was further validated in another anti-PD-1 monotherapy cohort (P = 0.011, n = 70) whereas no significance was observed in patients receiving anti-PD-L1 monotherapy (P = 0.135, n = 30). Therefore, our data suggest the roles of peripheral IgM+ memory B cells in predicting the responses to anti-PD-1 treatment in Chinese advanced NSCLC patients." @default.
- W3216014937 created "2021-12-06" @default.
- W3216014937 creator A5002234915 @default.
- W3216014937 creator A5004081762 @default.
- W3216014937 creator A5004928583 @default.
- W3216014937 creator A5010968379 @default.
- W3216014937 creator A5014251084 @default.
- W3216014937 creator A5018863416 @default.
- W3216014937 creator A5020992348 @default.
- W3216014937 creator A5027911071 @default.
- W3216014937 creator A5037204705 @default.
- W3216014937 creator A5038847559 @default.
- W3216014937 creator A5041465434 @default.
- W3216014937 creator A5060613485 @default.
- W3216014937 creator A5067565888 @default.
- W3216014937 creator A5073214723 @default.
- W3216014937 creator A5090716270 @default.
- W3216014937 date "2021-11-24" @default.
- W3216014937 modified "2023-10-17" @default.
- W3216014937 title "Predictable Roles of Peripheral IgM Memory B Cells for the Responses to Anti-PD-1 Monotherapy Against Advanced Non-Small Cell Lung Cancer" @default.
- W3216014937 cites W1978693882 @default.
- W3216014937 cites W1978896186 @default.
- W3216014937 cites W2003842888 @default.
- W3216014937 cites W2006236831 @default.
- W3216014937 cites W2232841288 @default.
- W3216014937 cites W2254907138 @default.
- W3216014937 cites W2512784295 @default.
- W3216014937 cites W2560367415 @default.
- W3216014937 cites W2605630275 @default.
- W3216014937 cites W2609289346 @default.
- W3216014937 cites W2655262992 @default.
- W3216014937 cites W2747774814 @default.
- W3216014937 cites W2766903152 @default.
- W3216014937 cites W2783417222 @default.
- W3216014937 cites W2795845948 @default.
- W3216014937 cites W2797675588 @default.
- W3216014937 cites W2798160602 @default.
- W3216014937 cites W2807246821 @default.
- W3216014937 cites W2807534769 @default.
- W3216014937 cites W2808455729 @default.
- W3216014937 cites W2899145148 @default.
- W3216014937 cites W2901472822 @default.
- W3216014937 cites W2909486828 @default.
- W3216014937 cites W2913558101 @default.
- W3216014937 cites W2942123458 @default.
- W3216014937 cites W2951492084 @default.
- W3216014937 cites W2973051889 @default.
- W3216014937 cites W2982049472 @default.
- W3216014937 cites W2995822774 @default.
- W3216014937 cites W2996038327 @default.
- W3216014937 cites W2998795792 @default.
- W3216014937 cites W3000282923 @default.
- W3216014937 cites W3000311037 @default.
- W3216014937 cites W3001895421 @default.
- W3216014937 cites W3003592141 @default.
- W3216014937 cites W3020886383 @default.
- W3216014937 cites W3021646013 @default.
- W3216014937 cites W3032968363 @default.
- W3216014937 cites W3044773069 @default.
- W3216014937 cites W3080948982 @default.
- W3216014937 cites W3091976617 @default.
- W3216014937 cites W3107639384 @default.
- W3216014937 cites W3116357308 @default.
- W3216014937 cites W3127118411 @default.
- W3216014937 cites W3165802165 @default.
- W3216014937 cites W4254345745 @default.
- W3216014937 doi "https://doi.org/10.3389/fimmu.2021.759217" @default.
- W3216014937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34899709" @default.
- W3216014937 hasPublicationYear "2021" @default.
- W3216014937 type Work @default.
- W3216014937 sameAs 3216014937 @default.
- W3216014937 citedByCount "14" @default.
- W3216014937 countsByYear W32160149372022 @default.
- W3216014937 countsByYear W32160149372023 @default.
- W3216014937 crossrefType "journal-article" @default.
- W3216014937 hasAuthorship W3216014937A5002234915 @default.
- W3216014937 hasAuthorship W3216014937A5004081762 @default.
- W3216014937 hasAuthorship W3216014937A5004928583 @default.
- W3216014937 hasAuthorship W3216014937A5010968379 @default.
- W3216014937 hasAuthorship W3216014937A5014251084 @default.
- W3216014937 hasAuthorship W3216014937A5018863416 @default.
- W3216014937 hasAuthorship W3216014937A5020992348 @default.
- W3216014937 hasAuthorship W3216014937A5027911071 @default.
- W3216014937 hasAuthorship W3216014937A5037204705 @default.
- W3216014937 hasAuthorship W3216014937A5038847559 @default.
- W3216014937 hasAuthorship W3216014937A5041465434 @default.
- W3216014937 hasAuthorship W3216014937A5060613485 @default.
- W3216014937 hasAuthorship W3216014937A5067565888 @default.
- W3216014937 hasAuthorship W3216014937A5073214723 @default.
- W3216014937 hasAuthorship W3216014937A5090716270 @default.
- W3216014937 hasBestOaLocation W32160149371 @default.
- W3216014937 hasConcept C121608353 @default.
- W3216014937 hasConcept C126322002 @default.
- W3216014937 hasConcept C143998085 @default.
- W3216014937 hasConcept C151956035 @default.
- W3216014937 hasConcept C159654299 @default.
- W3216014937 hasConcept C203014093 @default.
- W3216014937 hasConcept C2776090121 @default.
- W3216014937 hasConcept C2776256026 @default.
- W3216014937 hasConcept C2777701055 @default.