FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216070781> ?p ?o ?g. }

• W3216070781 endingPage "95" @default.
• W3216070781 startingPage "84" @default.
• W3216070781 abstract "Lack of clinically specific biomarkers has impeded the precise diagnosis of schizophrenia, meanwhile, limited comprehending of pathogenesis for schizophrenia has restricted the effective treatment.An integrated multi-omic approach, combining metabolomic platform (LC-MS and 1H NMR) and transcriptomic platform, was established to differentiate healthy subjects from schizophrenia patients. Based on filtered metabolites and genes, characteristic spectrums were further built. Then, representative metabolites and genes were screened out through Boruta algorithm. Moreover, characteristic diagnostic formulas were established via LASSO regression analysis.As a result, 86 differential metabolites (in line with amino acid metabolism, etc.) and 189 differential expression genes (involving in amino acid metabolic process, etc.) were obtained as potential biomarkers for schizophrenia. The latent interaction between metabolites with genes, such as HMGCLL1 with energy metabolism, etc., was further studied through the analysis of pathway-based integration. Moreover, fine predictive ability was attributed to characteristic metabolomic/transcriptomic diagnostic spectrums/formulas.The functional relationships of filtered metabolites and genes were studied, which could elaborate the pathological process of schizophrenia more systemically, supplying more precise information on mechanism description and diagnostic evidence of schizophrenia." @default.
• W3216070781 created "2021-12-06" @default.
• W3216070781 creator A5001473276 @default.
• W3216070781 creator A5014594202 @default.
• W3216070781 creator A5016036826 @default.
• W3216070781 creator A5019829518 @default.
• W3216070781 creator A5022632302 @default.
• W3216070781 creator A5028432371 @default.
• W3216070781 creator A5029358627 @default.
• W3216070781 creator A5034001763 @default.
• W3216070781 creator A5050912692 @default.
• W3216070781 creator A5052572849 @default.
• W3216070781 creator A5059446729 @default.
• W3216070781 creator A5079299290 @default.
• W3216070781 creator A5080278772 @default.
• W3216070781 creator A5088126310 @default.
• W3216070781 date "2022-01-01" @default.
• W3216070781 modified "2023-10-16" @default.
• W3216070781 title "An integrated pathological research for precise diagnosis of schizophrenia combining LC-MS/1H NMR metabolomics and transcriptomics" @default.
• W3216070781 cites W1553155385 @default.
• W3216070781 cites W1844074389 @default.
• W3216070781 cites W1904091658 @default.
• W3216070781 cites W1964010911 @default.
• W3216070781 cites W1971170113 @default.
• W3216070781 cites W2013584041 @default.
• W3216070781 cites W2035901862 @default.
• W3216070781 cites W2062099857 @default.
• W3216070781 cites W2088863821 @default.
• W3216070781 cites W2093290512 @default.
• W3216070781 cites W2140207977 @default.
• W3216070781 cites W2203046887 @default.
• W3216070781 cites W2234053937 @default.
• W3216070781 cites W2287154159 @default.
• W3216070781 cites W2326389904 @default.
• W3216070781 cites W2554126077 @default.
• W3216070781 cites W2562768475 @default.
• W3216070781 cites W2759454382 @default.
• W3216070781 cites W2765153238 @default.
• W3216070781 cites W2795013773 @default.
• W3216070781 cites W2795759749 @default.
• W3216070781 cites W2799558871 @default.
• W3216070781 cites W2802937633 @default.
• W3216070781 cites W2887053881 @default.
• W3216070781 cites W2890293708 @default.
• W3216070781 cites W2900260518 @default.
• W3216070781 cites W2900777723 @default.
• W3216070781 cites W2904884010 @default.
• W3216070781 cites W2907890703 @default.
• W3216070781 cites W2912121921 @default.
• W3216070781 cites W2913588197 @default.
• W3216070781 cites W2928665623 @default.
• W3216070781 cites W2937662066 @default.
• W3216070781 cites W2946569120 @default.
• W3216070781 cites W2948632957 @default.
• W3216070781 cites W2949507023 @default.
• W3216070781 cites W2969267340 @default.
• W3216070781 cites W2974949596 @default.
• W3216070781 cites W2980917642 @default.
• W3216070781 cites W2985524482 @default.
• W3216070781 cites W3000060162 @default.
• W3216070781 cites W3033752439 @default.
• W3216070781 cites W3041496722 @default.
• W3216070781 cites W3074433314 @default.
• W3216070781 cites W3080850982 @default.
• W3216070781 cites W3084293464 @default.
• W3216070781 cites W4211145950 @default.
• W3216070781 doi "https://doi.org/10.1016/j.cca.2021.11.028" @default.
• W3216070781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34863699" @default.
• W3216070781 hasPublicationYear "2022" @default.
• W3216070781 type Work @default.
• W3216070781 sameAs 3216070781 @default.
• W3216070781 citedByCount "4" @default.
• W3216070781 countsByYear W32160707812022 @default.
• W3216070781 countsByYear W32160707812023 @default.
• W3216070781 crossrefType "journal-article" @default.
• W3216070781 hasAuthorship W3216070781A5001473276 @default.
• W3216070781 hasAuthorship W3216070781A5014594202 @default.
• W3216070781 hasAuthorship W3216070781A5016036826 @default.
• W3216070781 hasAuthorship W3216070781A5019829518 @default.
• W3216070781 hasAuthorship W3216070781A5022632302 @default.
• W3216070781 hasAuthorship W3216070781A5028432371 @default.
• W3216070781 hasAuthorship W3216070781A5029358627 @default.
• W3216070781 hasAuthorship W3216070781A5034001763 @default.
• W3216070781 hasAuthorship W3216070781A5050912692 @default.
• W3216070781 hasAuthorship W3216070781A5052572849 @default.
• W3216070781 hasAuthorship W3216070781A5059446729 @default.
• W3216070781 hasAuthorship W3216070781A5079299290 @default.
• W3216070781 hasAuthorship W3216070781A5080278772 @default.
• W3216070781 hasAuthorship W3216070781A5088126310 @default.
• W3216070781 hasConcept C104317684 @default.
• W3216070781 hasConcept C118552586 @default.
• W3216070781 hasConcept C142724271 @default.
• W3216070781 hasConcept C150194340 @default.
• W3216070781 hasConcept C162317418 @default.
• W3216070781 hasConcept C207886595 @default.
• W3216070781 hasConcept C21565614 @default.
• W3216070781 hasConcept C2776412080 @default.
• W3216070781 hasConcept C55493867 @default.

• next