FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216073603> ?p ?o ?g. }

• W3216073603 abstract "Among CD4+ T cells, T helper 17 (Th17) cells are particularly susceptible to HIV-1 infection and are depleted from mucosal sites, which causes damage to the gut barrier, resulting in a microbial translocation-induced systemic inflammation, a hallmark of disease progression. Furthermore, a proportion of latently infected Th17 cells persist long term in the gastrointestinal lymphatic tract where a low-level HIV-1 transcription is observed. This residual viremia contributes to chronic immune activation. Thus, Th17 cells are key players in HIV pathogenesis and viral persistence. It is, however, unclear why these cells are highly susceptible to HIV-1 infection. Th17 cell differentiation depends on the expression of the master transcriptional regulator RORC2, a retinoic acid-related nuclear hormone receptor that regulates specific transcriptional programs by binding to promoter/enhancer DNA. Here, we report that RORC2 is a key host cofactor for HIV replication in Th17 cells. We found that specific inhibitors that bind to the RORC2 ligand-binding domain reduced HIV replication in CD4+ T cells. The depletion of RORC2 inhibited HIV-1 infection, whereas its overexpression enhanced it. RORC2 was also found to promote HIV-1 gene expression by binding to the nuclear receptor responsive element in the HIV-1 long terminal repeats (LTR). In treated HIV-1 patients, RORC2+ CD4 T cells contained more proviral DNA than RORC2- cells. Pharmacological inhibition of RORC2 potently reduced HIV-1 outgrowth in CD4+ T cells from antiretroviral-treated patients. Altogether, these results provide an explanation as to why Th17 cells are highly susceptible to HIV-1 infection and suggest that RORC2 may be a cell-specific target for HIV-1 therapy." @default.
• W3216073603 created "2021-12-06" @default.
• W3216073603 creator A5005774249 @default.
• W3216073603 creator A5012324889 @default.
• W3216073603 creator A5013541288 @default.
• W3216073603 creator A5016345250 @default.
• W3216073603 creator A5016884436 @default.
• W3216073603 creator A5036431603 @default.
• W3216073603 creator A5038607718 @default.
• W3216073603 creator A5044251474 @default.
• W3216073603 creator A5049148202 @default.
• W3216073603 creator A5053580679 @default.
• W3216073603 creator A5055204489 @default.
• W3216073603 creator A5059505755 @default.
• W3216073603 creator A5064769935 @default.
• W3216073603 creator A5065375213 @default.
• W3216073603 creator A5072914179 @default.
• W3216073603 creator A5088666814 @default.
• W3216073603 date "2021-11-24" @default.
• W3216073603 modified "2023-10-16" @default.
• W3216073603 title "Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth" @default.
• W3216073603 cites W1481073518 @default.
• W3216073603 cites W1533072919 @default.
• W3216073603 cites W1748436622 @default.
• W3216073603 cites W1749946895 @default.
• W3216073603 cites W1961668980 @default.
• W3216073603 cites W1972815843 @default.
• W3216073603 cites W1976591271 @default.
• W3216073603 cites W1996713852 @default.
• W3216073603 cites W2016117860 @default.
• W3216073603 cites W2021340905 @default.
• W3216073603 cites W2022159627 @default.
• W3216073603 cites W2023243934 @default.
• W3216073603 cites W2026237709 @default.
• W3216073603 cites W2026340875 @default.
• W3216073603 cites W2041128437 @default.
• W3216073603 cites W2052432894 @default.
• W3216073603 cites W2063628696 @default.
• W3216073603 cites W2067695164 @default.
• W3216073603 cites W2070036973 @default.
• W3216073603 cites W2072859659 @default.
• W3216073603 cites W2084765237 @default.
• W3216073603 cites W2088493593 @default.
• W3216073603 cites W2089242226 @default.
• W3216073603 cites W2091961926 @default.
• W3216073603 cites W2101266783 @default.
• W3216073603 cites W2102477325 @default.
• W3216073603 cites W2113434400 @default.
• W3216073603 cites W2117586443 @default.
• W3216073603 cites W2119532085 @default.
• W3216073603 cites W2122483069 @default.
• W3216073603 cites W2123093300 @default.
• W3216073603 cites W2133300386 @default.
• W3216073603 cites W2135325512 @default.
• W3216073603 cites W2139551787 @default.
• W3216073603 cites W2141419914 @default.
• W3216073603 cites W2142017607 @default.
• W3216073603 cites W2144991587 @default.
• W3216073603 cites W2152390002 @default.
• W3216073603 cites W2154728251 @default.
• W3216073603 cites W2167776710 @default.
• W3216073603 cites W2275273192 @default.
• W3216073603 cites W2313088707 @default.
• W3216073603 cites W2336017858 @default.
• W3216073603 cites W2358115279 @default.
• W3216073603 cites W2517479804 @default.
• W3216073603 cites W2554913814 @default.
• W3216073603 cites W2737124251 @default.
• W3216073603 cites W2740538710 @default.
• W3216073603 cites W2765096014 @default.
• W3216073603 cites W2776612223 @default.
• W3216073603 cites W2783354632 @default.
• W3216073603 cites W2794108759 @default.
• W3216073603 cites W2885704283 @default.
• W3216073603 cites W2885985538 @default.
• W3216073603 cites W2887584793 @default.
• W3216073603 cites W2898147166 @default.
• W3216073603 cites W2904232877 @default.
• W3216073603 cites W2916314751 @default.
• W3216073603 cites W2941001647 @default.
• W3216073603 cites W2992793004 @default.
• W3216073603 cites W3024427566 @default.
• W3216073603 cites W3047004407 @default.
• W3216073603 cites W3133680411 @default.
• W3216073603 cites W3165871245 @default.
• W3216073603 cites W937903590 @default.
• W3216073603 doi "https://doi.org/10.1073/pnas.2105927118" @default.
• W3216073603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34819367" @default.
• W3216073603 hasPublicationYear "2021" @default.
• W3216073603 type Work @default.
• W3216073603 sameAs 3216073603 @default.
• W3216073603 citedByCount "14" @default.
• W3216073603 countsByYear W32160736032022 @default.
• W3216073603 countsByYear W32160736032023 @default.
• W3216073603 crossrefType "journal-article" @default.
• W3216073603 hasAuthorship W3216073603A5005774249 @default.
• W3216073603 hasAuthorship W3216073603A5012324889 @default.
• W3216073603 hasAuthorship W3216073603A5013541288 @default.
• W3216073603 hasAuthorship W3216073603A5016345250 @default.
• W3216073603 hasAuthorship W3216073603A5016884436 @default.

• next