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- W3216088058 abstract "Inflammatory cytokine storm play a central role in disease progression of Covid-19. Many laboratory markers have been associated to an adverse outcome in COVID-19 patients. Lactate dehydrogenase enzyme (LDH) is a sensitive indicator of the cellular metabolic state, aerobic or anaerobic direction of glycolysis and cell injury. High lactate dehydrogenase level was significantly associated with severe COVID-19 pneumonia on admission.[1] <b>Aim:</b> to investigate if LDH, an easy laboratory test, could define the severity of Covid-19 pneumonia and guide physicians in their choice of therapeutic strategy. <b>Methods:</b> we analyzed laboratory tests to identify tissue damage and inflammatory status in 70 CoVID-19 patients (41 males and 29 females) admitted to Pneumology Department of Monaldi Hospital (Naples). We investigated the relationship between LDH values(normal range 80-300 U/L) and the type of therapeutic strategy (low and high flow oxigen therapy and non-invasive ventilation). <b>Results:</b> patients had a mean age of 67,28 years. Serum level of LDH was > 300 U/L in 71,42% of patients (first group) and <300 U/L in 28,58% of patients (second group). In the first group 44% of patients needed non invasive ventilation (CPAP/NIV), 38% needed high flow nasal cannulae oxygen therapy (HFNC) and 18% needed low flow oxigen therapy. In the second group 5% of patients needed CPAP/NIV, 40% needed HFNC and 55% needed low flow oxigen therapy. <b>Conclusions:</b> LDH seems to be related to severity of Covid-19 pneumonia and to the type of therapeutic strategy. Moreover could guide physicians in the choice of respiratory support such as non-invasive ventilation. [1] Li X et al. J Allergy Clin Immunol. 2020 Jul;10.1016/j.jaci.2020.04.006." @default.
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- W3216088058 date "2021-09-05" @default.
- W3216088058 modified "2023-09-25" @default.
- W3216088058 title "Correlation between lactate dehydrogenase and therapeutic strategy in Covid-19 pneumonia" @default.
- W3216088058 doi "https://doi.org/10.1183/13993003.congress-2021.pa1091" @default.
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