FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216135973> ?p ?o ?g. }

• W3216135973 endingPage "4761" @default.
• W3216135973 startingPage "4757" @default.
• W3216135973 abstract "The ineffectiveness and the slowdown of newer anti-TB drug approval rates directly indicate searching for potential alternative agents. However, validation of isolated phytochemicals through hit-and-trial experiments is more expensive and time-consuming. Simultaneously, cost-effective computational tools can recognize most potential candidates at an initial stage. The present study selected seven plant-derived polyphenols, then verified anti-TB and drug-ability profiles using advanced computational tools before the experimental study. Among all, the quercetin showed a potential docking-score within -8 to -11 kcal/mol than the standard isoniazid and ofloxacin, -5 to -10 kcal/mol. Additionally, quercetin exhibited a higher drug-ability score of 0.53 than isoniazid 0.19. Further, quercetin exhibited the minimum inhibitory concentration at 6 and 8 μg/mL, while ofloxacin showed at 2 μg/mL against InhA, and katG mutated Mtb-strains, respectively. Parallelly, quercetin showed promising free-radical-scavenging activity from nitric-oxide assay at IC50 = 14.92 µg/mL, and lesser-cytotoxicity from cultured HepG2 cell lines at IC50 = 159 µg/mL, respectively." @default.
• W3216135973 created "2021-12-06" @default.
• W3216135973 creator A5034716002 @default.
• W3216135973 creator A5038808308 @default.
• W3216135973 creator A5056586342 @default.
• W3216135973 creator A5065278114 @default.
• W3216135973 creator A5083740542 @default.
• W3216135973 date "2021-12-02" @default.
• W3216135973 modified "2023-10-17" @default.
• W3216135973 title "Antituberculosis, antioxidant and cytotoxicity profiles of quercetin: a systematic and cost-effective <i>in silico</i> and <i>in vitro</i> approach" @default.
• W3216135973 cites W1487878063 @default.
• W3216135973 cites W2133920756 @default.
• W3216135973 cites W2161973804 @default.
• W3216135973 cites W2251928001 @default.
• W3216135973 cites W2263708949 @default.
• W3216135973 cites W2290588100 @default.
• W3216135973 cites W2342805349 @default.
• W3216135973 cites W2515745817 @default.
• W3216135973 cites W2553659869 @default.
• W3216135973 cites W2729567278 @default.
• W3216135973 cites W2748053146 @default.
• W3216135973 cites W2803486635 @default.
• W3216135973 cites W2805761887 @default.
• W3216135973 cites W2888604931 @default.
• W3216135973 cites W2890585327 @default.
• W3216135973 cites W2953424608 @default.
• W3216135973 cites W3037117505 @default.
• W3216135973 cites W3038642684 @default.
• W3216135973 cites W4236412487 @default.
• W3216135973 doi "https://doi.org/10.1080/14786419.2021.2008387" @default.
• W3216135973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34854322" @default.
• W3216135973 hasPublicationYear "2021" @default.
• W3216135973 type Work @default.
• W3216135973 sameAs 3216135973 @default.
• W3216135973 citedByCount "6" @default.
• W3216135973 countsByYear W32161359732022 @default.
• W3216135973 countsByYear W32161359732023 @default.
• W3216135973 crossrefType "journal-article" @default.
• W3216135973 hasAuthorship W3216135973A5034716002 @default.
• W3216135973 hasAuthorship W3216135973A5038808308 @default.
• W3216135973 hasAuthorship W3216135973A5056586342 @default.
• W3216135973 hasAuthorship W3216135973A5065278114 @default.
• W3216135973 hasAuthorship W3216135973A5083740542 @default.
• W3216135973 hasBestOaLocation W32161359732 @default.
• W3216135973 hasConcept C104317684 @default.
• W3216135973 hasConcept C109316439 @default.
• W3216135973 hasConcept C142724271 @default.
• W3216135973 hasConcept C185592680 @default.
• W3216135973 hasConcept C202751555 @default.
• W3216135973 hasConcept C2775905019 @default.
• W3216135973 hasConcept C2775963812 @default.
• W3216135973 hasConcept C2776967927 @default.
• W3216135973 hasConcept C2777752497 @default.
• W3216135973 hasConcept C2778004101 @default.
• W3216135973 hasConcept C2778049240 @default.
• W3216135973 hasConcept C2778512257 @default.
• W3216135973 hasConcept C2781069245 @default.
• W3216135973 hasConcept C2781263971 @default.
• W3216135973 hasConcept C501593827 @default.
• W3216135973 hasConcept C55493867 @default.
• W3216135973 hasConcept C556039675 @default.
• W3216135973 hasConcept C70899900 @default.
• W3216135973 hasConcept C71924100 @default.
• W3216135973 hasConcept C86803240 @default.
• W3216135973 hasConcept C98274493 @default.
• W3216135973 hasConceptScore W3216135973C104317684 @default.
• W3216135973 hasConceptScore W3216135973C109316439 @default.
• W3216135973 hasConceptScore W3216135973C142724271 @default.
• W3216135973 hasConceptScore W3216135973C185592680 @default.
• W3216135973 hasConceptScore W3216135973C202751555 @default.
• W3216135973 hasConceptScore W3216135973C2775905019 @default.
• W3216135973 hasConceptScore W3216135973C2775963812 @default.
• W3216135973 hasConceptScore W3216135973C2776967927 @default.
• W3216135973 hasConceptScore W3216135973C2777752497 @default.
• W3216135973 hasConceptScore W3216135973C2778004101 @default.
• W3216135973 hasConceptScore W3216135973C2778049240 @default.
• W3216135973 hasConceptScore W3216135973C2778512257 @default.
• W3216135973 hasConceptScore W3216135973C2781069245 @default.
• W3216135973 hasConceptScore W3216135973C2781263971 @default.
• W3216135973 hasConceptScore W3216135973C501593827 @default.
• W3216135973 hasConceptScore W3216135973C55493867 @default.
• W3216135973 hasConceptScore W3216135973C556039675 @default.
• W3216135973 hasConceptScore W3216135973C70899900 @default.
• W3216135973 hasConceptScore W3216135973C71924100 @default.
• W3216135973 hasConceptScore W3216135973C86803240 @default.
• W3216135973 hasConceptScore W3216135973C98274493 @default.
• W3216135973 hasIssue "18" @default.
• W3216135973 hasLocation W32161359731 @default.
• W3216135973 hasLocation W32161359732 @default.
• W3216135973 hasLocation W32161359733 @default.
• W3216135973 hasOpenAccess W3216135973 @default.
• W3216135973 hasPrimaryLocation W32161359731 @default.
• W3216135973 hasRelatedWork W1978840408 @default.
• W3216135973 hasRelatedWork W2004992052 @default.
• W3216135973 hasRelatedWork W2038890001 @default.
• W3216135973 hasRelatedWork W2354557126 @default.
• W3216135973 hasRelatedWork W2356078531 @default.
• W3216135973 hasRelatedWork W2377953020 @default.

• next