Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216148833> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3216148833 abstract "Background: Atrioesophageal fistula (AEF) is a severe complication of left atrial radiofrequency (RF) ablation for the treatment of atrial fibrillation. Proactive cooling with a novel cooling device has been shown to significantly reduce thermal injury, with no AEFs yet encountered after thousands of treatments worldwide. Computer modeling suggested that lethal temperatures could be avoided with moderate-power and moderate-duration RF ablation. We aimed to evaluate the effects of proactive cooling during high-power short-duration (HPSD) ablation, and compare the computed results to clinical data and recently published experimental data.Methods: A computer model accounting for the left atrium and esophagus including the active cooling device was created. We used both the Arrhenius equation and 50oC isotherm to estimate the esophageal thermal damage during 50 W, 10 second and 90 W, 4 second RF ablations.Results: Under control conditions, temperatures across the esophageal wall exceeded the lethal isotherm, in agreement with recent experimental data. With proactive esophageal cooling in place, temperatures in the esophageal tissue were significantly reduced, with the resulting fraction of esophageal damage reduced by 74% under 50 W and 10 seconds of ablation, and by 82% under 90 W and 4 seconds of ablation. Esophageal damage was restricted to the epi-esophageal region, sparing the remainder of the esophageal tissue, including the mucosal surface.Conclusions: Proactive esophageal cooling significantly reduced temperatures and the resulting fraction of damage in the esophagus during HPSD ablation. These findings offer a mechanistic rationale explaining the absence of AEF encountered to date using proactive esophageal cooling." @default.
- W3216148833 created "2021-12-06" @default.
- W3216148833 creator A5002827110 @default.
- W3216148833 creator A5004343897 @default.
- W3216148833 creator A5047742063 @default.
- W3216148833 creator A5049067139 @default.
- W3216148833 creator A5066036276 @default.
- W3216148833 creator A5066359436 @default.
- W3216148833 creator A5073010716 @default.
- W3216148833 creator A5090633272 @default.
- W3216148833 date "2021-01-01" @default.
- W3216148833 modified "2023-09-24" @default.
- W3216148833 title "Proactive Esophageal Cooling Protects Against Thermal Insults During High-Power Short-Duration Radiofrequency Ablation" @default.
- W3216148833 cites W1580364606 @default.
- W3216148833 cites W1583406651 @default.
- W3216148833 cites W1892662038 @default.
- W3216148833 cites W2005735875 @default.
- W3216148833 cites W2014021394 @default.
- W3216148833 cites W2030722312 @default.
- W3216148833 cites W2062924224 @default.
- W3216148833 cites W2147898839 @default.
- W3216148833 cites W2321801558 @default.
- W3216148833 cites W2585919270 @default.
- W3216148833 cites W2759628821 @default.
- W3216148833 cites W2760971807 @default.
- W3216148833 cites W2778221885 @default.
- W3216148833 cites W2794887557 @default.
- W3216148833 cites W2890403231 @default.
- W3216148833 cites W2970948806 @default.
- W3216148833 cites W2981584498 @default.
- W3216148833 cites W2999143825 @default.
- W3216148833 cites W3004421150 @default.
- W3216148833 cites W3027843825 @default.
- W3216148833 cites W3028508296 @default.
- W3216148833 cites W3036040256 @default.
- W3216148833 cites W3092389571 @default.
- W3216148833 cites W3128762314 @default.
- W3216148833 cites W3136475920 @default.
- W3216148833 cites W3164087966 @default.
- W3216148833 cites W3164285297 @default.
- W3216148833 cites W3171867623 @default.
- W3216148833 cites W3181871826 @default.
- W3216148833 cites W3206376246 @default.
- W3216148833 cites W4239526824 @default.
- W3216148833 doi "https://doi.org/10.2139/ssrn.3967618" @default.
- W3216148833 hasPublicationYear "2021" @default.
- W3216148833 type Work @default.
- W3216148833 sameAs 3216148833 @default.
- W3216148833 citedByCount "0" @default.
- W3216148833 crossrefType "journal-article" @default.
- W3216148833 hasAuthorship W3216148833A5002827110 @default.
- W3216148833 hasAuthorship W3216148833A5004343897 @default.
- W3216148833 hasAuthorship W3216148833A5047742063 @default.
- W3216148833 hasAuthorship W3216148833A5049067139 @default.
- W3216148833 hasAuthorship W3216148833A5066036276 @default.
- W3216148833 hasAuthorship W3216148833A5066359436 @default.
- W3216148833 hasAuthorship W3216148833A5073010716 @default.
- W3216148833 hasAuthorship W3216148833A5090633272 @default.
- W3216148833 hasConcept C141071460 @default.
- W3216148833 hasConcept C164705383 @default.
- W3216148833 hasConcept C192562407 @default.
- W3216148833 hasConcept C2776131983 @default.
- W3216148833 hasConcept C2777819096 @default.
- W3216148833 hasConcept C2778902805 @default.
- W3216148833 hasConcept C2779161974 @default.
- W3216148833 hasConcept C2910474132 @default.
- W3216148833 hasConcept C71924100 @default.
- W3216148833 hasConceptScore W3216148833C141071460 @default.
- W3216148833 hasConceptScore W3216148833C164705383 @default.
- W3216148833 hasConceptScore W3216148833C192562407 @default.
- W3216148833 hasConceptScore W3216148833C2776131983 @default.
- W3216148833 hasConceptScore W3216148833C2777819096 @default.
- W3216148833 hasConceptScore W3216148833C2778902805 @default.
- W3216148833 hasConceptScore W3216148833C2779161974 @default.
- W3216148833 hasConceptScore W3216148833C2910474132 @default.
- W3216148833 hasConceptScore W3216148833C71924100 @default.
- W3216148833 hasLocation W32161488331 @default.
- W3216148833 hasOpenAccess W3216148833 @default.
- W3216148833 hasPrimaryLocation W32161488331 @default.
- W3216148833 hasRelatedWork W11522766 @default.
- W3216148833 hasRelatedWork W12473195 @default.
- W3216148833 hasRelatedWork W15250634 @default.
- W3216148833 hasRelatedWork W15492122 @default.
- W3216148833 hasRelatedWork W15998111 @default.
- W3216148833 hasRelatedWork W4835347 @default.
- W3216148833 hasRelatedWork W4920650 @default.
- W3216148833 hasRelatedWork W14248210 @default.
- W3216148833 hasRelatedWork W1683555 @default.
- W3216148833 hasRelatedWork W5909635 @default.
- W3216148833 isParatext "false" @default.
- W3216148833 isRetracted "false" @default.
- W3216148833 magId "3216148833" @default.
- W3216148833 workType "article" @default.