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• W3216189714 abstract "A bstract Retinal prostheses are a promising strategy to restore sight to patients with retinal degenerative diseases. These devices compensate for the loss of photoreceptors by electrically stimulating neurons in the retina. Currently, the visual function that can be recovered with such devices is very limited. This is due, in part, to current spread, unintended axonal activation, and the limited resolution of existing devices. Here we show, using a recent model of prosthetic vision, that optimizing how visual stimuli are encoded by the device can help overcome some of these limitations, leading to dramatic improvements in visual perception. We propose a strategy to do this in practice, using patients’ feedback in a visual task. The main challenge of our approach comes from the fact that, typically, one only has access to a limited number of noisy responses from patients. We propose two ways to deal with this: first, we use a model of prosthetic vision to constrain and simplify the optimization; second, we use preferential Bayesian optimization to efficiently learn the encoder using minimal trials. To test our approach, we presented healthy subjects with visual stimuli generated by a recent model of prosthetic vision, to replicate the perceptual experience of patients fitted with an implant. Our optimization procedure led to significant and robust improvements in perceived image quality, that transferred to increased performance in other tasks. Importantly, our strategy is agnostic to the type of prosthesis and thus could readily be implemented in existing implants." @default.
• W3216189714 created "2021-12-06" @default.
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• W3216189714 date "2021-11-25" @default.
• W3216189714 modified "2023-09-25" @default.
• W3216189714 title "Human-in-the-loop optimization of visual prosthetic stimulation" @default.
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• W3216189714 doi "https://doi.org/10.1101/2021.11.24.469867" @default.
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