FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216221841> ?p ?o ?g. }

• W3216221841 abstract "Although painkillers could alleviate some of the symptoms, there are no drugs that really cope with the intervertebral disc degeneration (IDD) at present, so it is urgent to find a cure that could prevent or reverse the progression of IDD. During the development of IDD, the cartilaginous end plates (EPs) become hypertrophic and porous by the increase of osteoclast activities, which hinder the penetration of nutrition. The compositional and structural degeneration of the EP may cause both nutritional as well as mechanical impairment to the nucleus pulposus (NP) so that developing drugs that target the degenerating EP may be another option in addition to targeting the NP. In the lumbar spine instability mouse model, we found increased porosity in the cartilaginous EP, accompanied by the decrease in total intervertebral disc volume. Panax notoginseng saponins (PNS), a traditional Chinese patent drug with anti-osteoclastogenesis effect, could alleviate IDD by inhibiting aberrant osteoclast activation in the porous EP. Further in vitro experiment validated that PNS inhibit the receptor activator of nuclear factor kappa-Β ligand-induced osteoclast differentiation, while the transcriptional activation of PAX6 may be involved in the mechanism, which had been defined as an inhibitory transcription factor in osteoclastogenesis. These findings may provide a novel therapeutic strategy for IDD." @default.
• W3216221841 created "2021-12-06" @default.
• W3216221841 creator A5024324249 @default.
• W3216221841 creator A5033837381 @default.
• W3216221841 creator A5034711601 @default.
• W3216221841 creator A5056457613 @default.
• W3216221841 creator A5061119584 @default.
• W3216221841 creator A5069689440 @default.
• W3216221841 creator A5069984322 @default.
• W3216221841 creator A5070920259 @default.
• W3216221841 creator A5073043891 @default.
• W3216221841 creator A5081482550 @default.
• W3216221841 creator A5082089959 @default.
• W3216221841 date "2021-11-30" @default.
• W3216221841 modified "2023-10-10" @default.
• W3216221841 title "Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice" @default.
• W3216221841 cites W1976168752 @default.
• W3216221841 cites W1980794230 @default.
• W3216221841 cites W1985738247 @default.
• W3216221841 cites W1989077880 @default.
• W3216221841 cites W1990912219 @default.
• W3216221841 cites W2002530161 @default.
• W3216221841 cites W2016503378 @default.
• W3216221841 cites W2022684362 @default.
• W3216221841 cites W2038420791 @default.
• W3216221841 cites W2043242284 @default.
• W3216221841 cites W2045200773 @default.
• W3216221841 cites W2053025121 @default.
• W3216221841 cites W2057609917 @default.
• W3216221841 cites W2088027299 @default.
• W3216221841 cites W2098085126 @default.
• W3216221841 cites W2104135468 @default.
• W3216221841 cites W2108255861 @default.
• W3216221841 cites W2111763891 @default.
• W3216221841 cites W2121836743 @default.
• W3216221841 cites W2126797959 @default.
• W3216221841 cites W2148606789 @default.
• W3216221841 cites W2166369828 @default.
• W3216221841 cites W2290008885 @default.
• W3216221841 cites W2347013783 @default.
• W3216221841 cites W2400495424 @default.
• W3216221841 cites W2467796320 @default.
• W3216221841 cites W2790410554 @default.
• W3216221841 cites W2898624194 @default.
• W3216221841 cites W2904782810 @default.
• W3216221841 cites W2912664379 @default.
• W3216221841 cites W2994957938 @default.
• W3216221841 cites W3005689822 @default.
• W3216221841 cites W3011204306 @default.
• W3216221841 cites W3020875021 @default.
• W3216221841 cites W3091335342 @default.
• W3216221841 cites W3092200253 @default.
• W3216221841 cites W3113347506 @default.
• W3216221841 cites W3142325956 @default.
• W3216221841 cites W3184297834 @default.
• W3216221841 cites W4211136641 @default.
• W3216221841 cites W580497271 @default.
• W3216221841 doi "https://doi.org/10.1002/jsp2.1182" @default.
• W3216221841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35005448" @default.
• W3216221841 hasPublicationYear "2021" @default.
• W3216221841 type Work @default.
• W3216221841 sameAs 3216221841 @default.
• W3216221841 citedByCount "6" @default.
• W3216221841 countsByYear W32162218412021 @default.
• W3216221841 countsByYear W32162218412022 @default.
• W3216221841 countsByYear W32162218412023 @default.
• W3216221841 crossrefType "journal-article" @default.
• W3216221841 hasAuthorship W3216221841A5024324249 @default.
• W3216221841 hasAuthorship W3216221841A5033837381 @default.
• W3216221841 hasAuthorship W3216221841A5034711601 @default.
• W3216221841 hasAuthorship W3216221841A5056457613 @default.
• W3216221841 hasAuthorship W3216221841A5061119584 @default.
• W3216221841 hasAuthorship W3216221841A5069689440 @default.
• W3216221841 hasAuthorship W3216221841A5069984322 @default.
• W3216221841 hasAuthorship W3216221841A5070920259 @default.
• W3216221841 hasAuthorship W3216221841A5073043891 @default.
• W3216221841 hasAuthorship W3216221841A5081482550 @default.
• W3216221841 hasAuthorship W3216221841A5082089959 @default.
• W3216221841 hasBestOaLocation W32162218413 @default.
• W3216221841 hasConcept C104317684 @default.
• W3216221841 hasConcept C105702510 @default.
• W3216221841 hasConcept C126322002 @default.
• W3216221841 hasConcept C142724271 @default.
• W3216221841 hasConcept C170493617 @default.
• W3216221841 hasConcept C185592680 @default.
• W3216221841 hasConcept C204787440 @default.
• W3216221841 hasConcept C2776033226 @default.
• W3216221841 hasConcept C2777755357 @default.
• W3216221841 hasConcept C2779354088 @default.
• W3216221841 hasConcept C2781212864 @default.
• W3216221841 hasConcept C44575665 @default.
• W3216221841 hasConcept C502942594 @default.
• W3216221841 hasConcept C55493867 @default.
• W3216221841 hasConcept C71924100 @default.
• W3216221841 hasConcept C86339819 @default.
• W3216221841 hasConcept C86803240 @default.
• W3216221841 hasConcept C88045685 @default.
• W3216221841 hasConcept C95444343 @default.
• W3216221841 hasConceptScore W3216221841C104317684 @default.
• W3216221841 hasConceptScore W3216221841C105702510 @default.

• next