FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216242249> ?p ?o ?g. }

• W3216242249 abstract "The progression of neurodegenerative diseases is reciprocally associated with impairments in peripheral immune responses. We investigated different contexts of selective neurodegeneration to identify specific alterations of peripheral immune cells and, at the same time, discover potential biomarkers associated to this pathological condition. Consequently, a model of human cerebellar degeneration and ataxia -the Purkinje Cell Degeneration (PCD) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., Purkinje cells in the cerebellum and mitral cells in the olfactory bulb. Infiltrated leukocytes were studied in both brain areas and compared with those from other standardized neuroinflammatory models obtained by administering either gamma radiation or lipopolysaccharide. Moreover, both myeloid and lymphoid splenic populations were analyzed by flow cytometry, focusing on markers of functional maturity and antigen presentation. The severity and type of neural damage and inflammation affected immune cell infiltration. Leukocytes were more numerous in the cerebellum of PCD mice, being located predominantly within those cerebellar layers mostly affected by neurodegeneration, in a completely different manner than the typical models of induced neuroinflammation. Furthermore, the milder degeneration of the olfactory bulb did not foster leukocyte attraction. Concerning the splenic analysis, in PCD mice we found: (1) a decreased percentage of several myeloid cell subsets, and (2) a reduced mean fluorescence intensity in those myeloid markers related to both antigen presentation and functional maturity. In conclusion, the selective degeneration of Purkinje cells triggers a specific effect on peripheral immune cells, fostering both attraction and functional changes. This fact endorses the employment of peripheral immune cell populations as concrete biomarkers for monitoring different neuronal death processes." @default.
• W3216242249 created "2021-12-06" @default.
• W3216242249 creator A5006127905 @default.
• W3216242249 creator A5008422245 @default.
• W3216242249 creator A5010291517 @default.
• W3216242249 creator A5034504239 @default.
• W3216242249 creator A5043414758 @default.
• W3216242249 creator A5049451965 @default.
• W3216242249 creator A5051361109 @default.
• W3216242249 creator A5069325249 @default.
• W3216242249 creator A5074024292 @default.
• W3216242249 date "2021-11-30" @default.
• W3216242249 modified "2023-10-10" @default.
• W3216242249 title "The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations" @default.
• W3216242249 cites W1515592753 @default.
• W3216242249 cites W1561739940 @default.
• W3216242249 cites W1598703170 @default.
• W3216242249 cites W1948168563 @default.
• W3216242249 cites W1967640115 @default.
• W3216242249 cites W1974847762 @default.
• W3216242249 cites W1975110303 @default.
• W3216242249 cites W1988869829 @default.
• W3216242249 cites W1991774681 @default.
• W3216242249 cites W1994772581 @default.
• W3216242249 cites W1997245227 @default.
• W3216242249 cites W1999419270 @default.
• W3216242249 cites W2000443400 @default.
• W3216242249 cites W2001270136 @default.
• W3216242249 cites W2006035554 @default.
• W3216242249 cites W2006964467 @default.
• W3216242249 cites W2007953331 @default.
• W3216242249 cites W2013001148 @default.
• W3216242249 cites W2017689311 @default.
• W3216242249 cites W2019835154 @default.
• W3216242249 cites W2042089580 @default.
• W3216242249 cites W2053437895 @default.
• W3216242249 cites W2055750901 @default.
• W3216242249 cites W2067365613 @default.
• W3216242249 cites W2070870122 @default.
• W3216242249 cites W2084381564 @default.
• W3216242249 cites W2085667648 @default.
• W3216242249 cites W2091637792 @default.
• W3216242249 cites W2113058827 @default.
• W3216242249 cites W2115999215 @default.
• W3216242249 cites W2117000810 @default.
• W3216242249 cites W2119166600 @default.
• W3216242249 cites W2119656827 @default.
• W3216242249 cites W2124523695 @default.
• W3216242249 cites W2131624778 @default.
• W3216242249 cites W2134205701 @default.
• W3216242249 cites W2136879071 @default.
• W3216242249 cites W2141363596 @default.
• W3216242249 cites W2142242761 @default.
• W3216242249 cites W2152853209 @default.
• W3216242249 cites W2157503003 @default.
• W3216242249 cites W2175869408 @default.
• W3216242249 cites W2252312554 @default.
• W3216242249 cites W2264054438 @default.
• W3216242249 cites W2265854557 @default.
• W3216242249 cites W2280077905 @default.
• W3216242249 cites W2283963041 @default.
• W3216242249 cites W2307324788 @default.
• W3216242249 cites W2469685265 @default.
• W3216242249 cites W2507473720 @default.
• W3216242249 cites W2528080441 @default.
• W3216242249 cites W2593488234 @default.
• W3216242249 cites W2602024874 @default.
• W3216242249 cites W2607829140 @default.
• W3216242249 cites W2610627565 @default.
• W3216242249 cites W2614585260 @default.
• W3216242249 cites W2740837741 @default.
• W3216242249 cites W2743858239 @default.
• W3216242249 cites W2749944343 @default.
• W3216242249 cites W2766931716 @default.
• W3216242249 cites W2767008385 @default.
• W3216242249 cites W2775579333 @default.
• W3216242249 cites W2777249549 @default.
• W3216242249 cites W2780137098 @default.
• W3216242249 cites W2788115976 @default.
• W3216242249 cites W2794869838 @default.
• W3216242249 cites W2800767933 @default.
• W3216242249 cites W2802869568 @default.
• W3216242249 cites W2806835943 @default.
• W3216242249 cites W2809209374 @default.
• W3216242249 cites W2809899329 @default.
• W3216242249 cites W2883082006 @default.
• W3216242249 cites W2890498338 @default.
• W3216242249 cites W2898746313 @default.
• W3216242249 cites W2901408775 @default.
• W3216242249 cites W2912225813 @default.
• W3216242249 cites W2916724393 @default.
• W3216242249 cites W2922830355 @default.
• W3216242249 cites W2938494496 @default.
• W3216242249 cites W2943261811 @default.
• W3216242249 cites W2945437891 @default.
• W3216242249 cites W3004302491 @default.
• W3216242249 doi "https://doi.org/10.3389/fncel.2021.773696" @default.
• W3216242249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34916910" @default.
• W3216242249 hasPublicationYear "2021" @default.
• W3216242249 type Work @default.

• next