Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216254517> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3216254517 abstract "Abstract Background: Docosahexaenoic acid (DHA) has been reported to slow the tumor growth and improve prognosis, and been used to co-operate with many other chemotherapy medicines. Up to now, survey focuses on the interaction between DHA and radiation is relatively modest. Our study sought to evaluate the changes of radiosensitivity caused by DHA on esophageal cancer cells. Besides, potential mechanism and molecular are needed to be explored. Results： DHA enhanced proliferation inhibition of irradiation on esophageal cancer cells. DNA damage, especially double-strand break, induced by irradiation, was sharply increased by DHA addition. DHA accelerated G2/M phase blocking, cell apoptosis and lipid peroxidation after radiotherapy. The similar outcomings were observed in mouse xenograft tumor experiment that the malignancy substantially dismissed after the combined treatment of DHA and irradiation. Moreover, PPAR -γ was verified to increase post-treatment. Suppression of PPAR -γ would attenuate the radio sensitization triggered by DHA incompletely. Conclusion： DHA could improve radio sensitivity in esophageal squamous cancer cells in vivo and in vitro by activating PPAR -γ. Due to its explicitly usage and convenient, DHA and other PPAR -γ agonists would serve as an adjuvant therapy before radiotherapy if the clinical trials indicated positive from now on." @default.
- W3216254517 created "2021-12-06" @default.
- W3216254517 creator A5023492006 @default.
- W3216254517 creator A5033267658 @default.
- W3216254517 creator A5051114489 @default.
- W3216254517 creator A5062026165 @default.
- W3216254517 creator A5074173740 @default.
- W3216254517 creator A5078674610 @default.
- W3216254517 creator A5089695069 @default.
- W3216254517 date "2021-11-19" @default.
- W3216254517 modified "2023-10-16" @default.
- W3216254517 title "Pronounced Enhancement in Radiosensitization of Esophagus Cancer Cultivated in Docosahexaenoic Acid Via The PPAR-γ Activation" @default.
- W3216254517 doi "https://doi.org/10.21203/rs.3.rs-1088207/v1" @default.
- W3216254517 hasPublicationYear "2021" @default.
- W3216254517 type Work @default.
- W3216254517 sameAs 3216254517 @default.
- W3216254517 citedByCount "0" @default.
- W3216254517 crossrefType "posted-content" @default.
- W3216254517 hasAuthorship W3216254517A5023492006 @default.
- W3216254517 hasAuthorship W3216254517A5033267658 @default.
- W3216254517 hasAuthorship W3216254517A5051114489 @default.
- W3216254517 hasAuthorship W3216254517A5062026165 @default.
- W3216254517 hasAuthorship W3216254517A5074173740 @default.
- W3216254517 hasAuthorship W3216254517A5078674610 @default.
- W3216254517 hasAuthorship W3216254517A5089695069 @default.
- W3216254517 hasBestOaLocation W32162545171 @default.
- W3216254517 hasConcept C121608353 @default.
- W3216254517 hasConcept C126322002 @default.
- W3216254517 hasConcept C150903083 @default.
- W3216254517 hasConcept C185592680 @default.
- W3216254517 hasConcept C190283241 @default.
- W3216254517 hasConcept C19038510 @default.
- W3216254517 hasConcept C19106626 @default.
- W3216254517 hasConcept C203014093 @default.
- W3216254517 hasConcept C206684579 @default.
- W3216254517 hasConcept C207001950 @default.
- W3216254517 hasConcept C2776151105 @default.
- W3216254517 hasConcept C2777171753 @default.
- W3216254517 hasConcept C2779399171 @default.
- W3216254517 hasConcept C2779742542 @default.
- W3216254517 hasConcept C2780829032 @default.
- W3216254517 hasConcept C502942594 @default.
- W3216254517 hasConcept C509974204 @default.
- W3216254517 hasConcept C543025807 @default.
- W3216254517 hasConcept C55493867 @default.
- W3216254517 hasConcept C71924100 @default.
- W3216254517 hasConcept C86803240 @default.
- W3216254517 hasConcept C96232424 @default.
- W3216254517 hasConcept C98274493 @default.
- W3216254517 hasConceptScore W3216254517C121608353 @default.
- W3216254517 hasConceptScore W3216254517C126322002 @default.
- W3216254517 hasConceptScore W3216254517C150903083 @default.
- W3216254517 hasConceptScore W3216254517C185592680 @default.
- W3216254517 hasConceptScore W3216254517C190283241 @default.
- W3216254517 hasConceptScore W3216254517C19038510 @default.
- W3216254517 hasConceptScore W3216254517C19106626 @default.
- W3216254517 hasConceptScore W3216254517C203014093 @default.
- W3216254517 hasConceptScore W3216254517C206684579 @default.
- W3216254517 hasConceptScore W3216254517C207001950 @default.
- W3216254517 hasConceptScore W3216254517C2776151105 @default.
- W3216254517 hasConceptScore W3216254517C2777171753 @default.
- W3216254517 hasConceptScore W3216254517C2779399171 @default.
- W3216254517 hasConceptScore W3216254517C2779742542 @default.
- W3216254517 hasConceptScore W3216254517C2780829032 @default.
- W3216254517 hasConceptScore W3216254517C502942594 @default.
- W3216254517 hasConceptScore W3216254517C509974204 @default.
- W3216254517 hasConceptScore W3216254517C543025807 @default.
- W3216254517 hasConceptScore W3216254517C55493867 @default.
- W3216254517 hasConceptScore W3216254517C71924100 @default.
- W3216254517 hasConceptScore W3216254517C86803240 @default.
- W3216254517 hasConceptScore W3216254517C96232424 @default.
- W3216254517 hasConceptScore W3216254517C98274493 @default.
- W3216254517 hasLocation W32162545171 @default.
- W3216254517 hasOpenAccess W3216254517 @default.
- W3216254517 hasPrimaryLocation W32162545171 @default.
- W3216254517 hasRelatedWork W2017363493 @default.
- W3216254517 hasRelatedWork W2051373027 @default.
- W3216254517 hasRelatedWork W2071443064 @default.
- W3216254517 hasRelatedWork W2170320712 @default.
- W3216254517 hasRelatedWork W2416836621 @default.
- W3216254517 hasRelatedWork W2501960686 @default.
- W3216254517 hasRelatedWork W2990214591 @default.
- W3216254517 hasRelatedWork W3012168770 @default.
- W3216254517 hasRelatedWork W3216254517 @default.
- W3216254517 hasRelatedWork W2892891728 @default.
- W3216254517 isParatext "false" @default.
- W3216254517 isRetracted "false" @default.
- W3216254517 magId "3216254517" @default.
- W3216254517 workType "article" @default.