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- W3216282807 abstract "Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as evidenced by the approval of two RNA therapies and mRNA COVID‐19 vaccines. In this review, an overview on different classes of lipid nanoparticles, including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, is first provided, followed by the introduction of their preparation methods. Then the characterizations of lipid nanoparticles are briefly reviewed and their applications in encapsulating and delivering hydrophobic drugs, hydrophilic drugs, and RNAs are highlighted. Finally, various applications of lipid nanoparticles for overcoming different delivery challenges, including crossing the blood–brain barrier, targeted delivery, and various routes of administration, are summarized. Lipid nanoparticles as drug delivery systems offer many attractive benefits such as great biocompatibility, ease of preparation, feasibility of scale‐up, nontoxicity, and targeted delivery, while current challenges in drug delivery warrant future studies about structure–function correlations, large‐scale production, and targeted delivery to realize the full potential of lipid nanoparticles for wider clinical and pharmaceutical applications in future." @default.
- W3216282807 created "2021-12-06" @default.
- W3216282807 creator A5007335297 @default.
- W3216282807 creator A5012864350 @default.
- W3216282807 creator A5019914168 @default.
- W3216282807 creator A5086835948 @default.
- W3216282807 creator A5086945714 @default.
- W3216282807 creator A5089614549 @default.
- W3216282807 date "2021-11-25" @default.
- W3216282807 modified "2023-10-14" @default.
- W3216282807 title "Lipid Nanoparticles for Drug Delivery" @default.
- W3216282807 cites W1502452493 @default.
- W3216282807 cites W1568769949 @default.
- W3216282807 cites W1700609558 @default.
- W3216282807 cites W1922758105 @default.
- W3216282807 cites W1930709060 @default.
- W3216282807 cites W1966231387 @default.
- W3216282807 cites W1968631214 @default.
- W3216282807 cites W1974050571 @default.
- W3216282807 cites W1976779766 @default.
- W3216282807 cites W1979326401 @default.
- W3216282807 cites W1983196010 @default.
- W3216282807 cites W1987433127 @default.
- W3216282807 cites W1989230986 @default.
- W3216282807 cites W1991208841 @default.
- W3216282807 cites W1995770815 @default.
- W3216282807 cites W1999122040 @default.
- W3216282807 cites W2007333720 @default.
- W3216282807 cites W2011062614 @default.
- W3216282807 cites W2012318066 @default.
- W3216282807 cites W2013630484 @default.
- W3216282807 cites W2015452026 @default.
- W3216282807 cites W2017928177 @default.
- W3216282807 cites W2018504340 @default.
- W3216282807 cites W2024341039 @default.
- W3216282807 cites W2032108684 @default.
- W3216282807 cites W2032678451 @default.
- W3216282807 cites W2036113930 @default.
- W3216282807 cites W2038375609 @default.
- W3216282807 cites W2040594573 @default.
- W3216282807 cites W2049975169 @default.
- W3216282807 cites W2051091654 @default.
- W3216282807 cites W2051925512 @default.
- W3216282807 cites W2064776000 @default.
- W3216282807 cites W2067629397 @default.
- W3216282807 cites W2070803838 @default.
- W3216282807 cites W2075385589 @default.
- W3216282807 cites W2077441973 @default.
- W3216282807 cites W2077925518 @default.
- W3216282807 cites W2081926138 @default.
- W3216282807 cites W2085248918 @default.
- W3216282807 cites W2087997669 @default.
- W3216282807 cites W2093311517 @default.
- W3216282807 cites W2093677418 @default.
- W3216282807 cites W2104290477 @default.
- W3216282807 cites W2111211179 @default.
- W3216282807 cites W2112871229 @default.
- W3216282807 cites W2114403974 @default.
- W3216282807 cites W2125470506 @default.
- W3216282807 cites W2133647054 @default.
- W3216282807 cites W2134961336 @default.
- W3216282807 cites W2136606745 @default.
- W3216282807 cites W2136657773 @default.
- W3216282807 cites W2144907950 @default.
- W3216282807 cites W2147575825 @default.
- W3216282807 cites W2147655511 @default.
- W3216282807 cites W2155606275 @default.
- W3216282807 cites W2166737662 @default.
- W3216282807 cites W2265120954 @default.
- W3216282807 cites W2292350703 @default.
- W3216282807 cites W2323505647 @default.
- W3216282807 cites W2337584310 @default.
- W3216282807 cites W2418606199 @default.
- W3216282807 cites W2464231245 @default.
- W3216282807 cites W2489473034 @default.
- W3216282807 cites W2520512268 @default.
- W3216282807 cites W2533770446 @default.
- W3216282807 cites W2569161293 @default.
- W3216282807 cites W2581117202 @default.
- W3216282807 cites W2583093292 @default.
- W3216282807 cites W2595051139 @default.
- W3216282807 cites W2599276599 @default.
- W3216282807 cites W2607742781 @default.
- W3216282807 cites W2610273741 @default.
- W3216282807 cites W2610788148 @default.
- W3216282807 cites W2617388155 @default.
- W3216282807 cites W2630192492 @default.
- W3216282807 cites W2742287127 @default.
- W3216282807 cites W2773884070 @default.
- W3216282807 cites W2788099605 @default.
- W3216282807 cites W2789728104 @default.
- W3216282807 cites W2790347249 @default.
- W3216282807 cites W2795989070 @default.
- W3216282807 cites W2800742174 @default.
- W3216282807 cites W2803106137 @default.
- W3216282807 cites W2807895903 @default.
- W3216282807 cites W2810385438 @default.
- W3216282807 cites W2811214319 @default.
- W3216282807 cites W2883481262 @default.
- W3216282807 cites W2890167612 @default.