FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216291274> ?p ?o ?g. }

• W3216291274 endingPage "88" @default.
• W3216291274 startingPage "88" @default.
• W3216291274 abstract "<h3>Importance</h3> Patients 80 years and older with pancreatic ductal adenocarcinoma (PDAC) have not consistently received treatments that have established benefits in younger older adults (aged 60-79 years), yet patients 80 years and older are increasingly being offered surgery. Whether adjuvant chemotherapy (AC) provides additional benefit among patients 80 years and older with PDAC following surgery is not well understood. <h3>Objective</h3> To describe patterns of AC use in patients 80 years and older following surgical resection of PDAC and to compare overall survival between patients who received AC and those who did not. <h3>Design, Setting, and Participants</h3> Retrospective cohort study among patients 80 years or older diagnosed with PDAC (stage I-III) between 2004 to 2016 who underwent a pancreaticoduodenectomy at hospitals across the US reporting to the National Cancer Database. <h3>Exposures</h3> AC vs no AC 90 days following diagnosis of PDAC. <h3>Main Outcomes and Measures</h3> The proportion of patients who received AC was assessed over the study period. Overall survival was compared between patients who received AC and those who did not using Kaplan-Meier estimates and multivariable Cox proportional hazards regression. A landmark analysis was performed to address immortal time bias. A propensity score analysis was performed to address indication bias. Subgroup analyses were conducted in node-negative, margin-negative, clinically complex, node-positive, and margin-positive cohorts. <h3>Results</h3> Between 2004 and 2016, 2569 patients 80 years and older (median [IQR] age, 82 [81-84] years; 1427 were women [55.5%]) underwent surgery for PDAC. Of these patients, 1217 (47.4%) received AC. Findings showed an 18.6% (95% CI, 8.0%-29.0%;<i>P</i> = .001) absolute increase in the use of AC among older adults who underwent a pancreaticoduodenectomy comparing rates in 2004 vs 2016. Receipt of AC was associated with a longer median survival (17.2 months; 95% CI, 16.1-19.0) compared with those who did not receive AC (12.7 months; 95% CI, 11.8-13.6). This association was consistent in propensity and subgroup analyses. In multivariable analysis, receipt of AC (hazard ratio [HR], 0.72; 95% CI, 0.65-0.79;<i>P</i> < .001), female sex (HR, 0.88; 95% CI, 0.80-0.96;<i>P</i> < .001), and surgery in the more recent time period (≥2011) (HR, 0.90; 95% CI, 0.82-0.99;<i>P</i> = .02) were associated with a decreased hazard of death. An increased hazard of death was associated with higher pathologic stage (stage II: HR, 1.68; 95% CI, 1.43-1.97;<i>P</i> < .001; stage III: HR, 2.39; 95% CI, 1.88-3.04;<i>P</i> < .001), positive surgical margins (HR, 1.49; 95% CI, 1.34-1.65;<i>P</i> < .001), length of stay greater than median (10 days) (HR, 1.17; 95% CI, 1.07-1.28;<i>P</i> < .001), and receipt of oncologic care at a nonacademic facilities (Community Cancer Program: HR, 1.20; 95% CI, 1.07-1.35;<i>P</i> < .001; Integrated Network Cancer Program: HR, 1.25; 95% CI, 1.07-1.46;<i>P</i> < .001). <h3>Conclusions and Relevance</h3> In this cohort study, the use of AC among patients who underwent resection for PDAC increased over the study period, yet it still was administered to fewer than 50% of patients. Receipt of AC was associated with a longer median survival." @default.
• W3216291274 created "2021-12-06" @default.
• W3216291274 creator A5009699993 @default.
• W3216291274 creator A5039136616 @default.
• W3216291274 creator A5047496278 @default.
• W3216291274 creator A5049946592 @default.
• W3216291274 creator A5053848207 @default.
• W3216291274 creator A5088893766 @default.
• W3216291274 date "2022-01-01" @default.
• W3216291274 modified "2023-10-16" @default.
• W3216291274 title "Patterns of Adjuvant Chemotherapy Use and Association With Survival in Adults 80 Years and Older With Pancreatic Adenocarcinoma" @default.
• W3216291274 cites W1964783424 @default.
• W3216291274 cites W1967619929 @default.
• W3216291274 cites W1981018384 @default.
• W3216291274 cites W1983978003 @default.
• W3216291274 cites W1986168976 @default.
• W3216291274 cites W1990277620 @default.
• W3216291274 cites W2000496570 @default.
• W3216291274 cites W2010571969 @default.
• W3216291274 cites W2013507617 @default.
• W3216291274 cites W2051448584 @default.
• W3216291274 cites W2052986113 @default.
• W3216291274 cites W2067259348 @default.
• W3216291274 cites W2068707299 @default.
• W3216291274 cites W2078159453 @default.
• W3216291274 cites W2090448540 @default.
• W3216291274 cites W2110847259 @default.
• W3216291274 cites W2126838184 @default.
• W3216291274 cites W2129168200 @default.
• W3216291274 cites W2129197203 @default.
• W3216291274 cites W2129204015 @default.
• W3216291274 cites W2129884672 @default.
• W3216291274 cites W2132799739 @default.
• W3216291274 cites W2142809913 @default.
• W3216291274 cites W2154221980 @default.
• W3216291274 cites W2259903214 @default.
• W3216291274 cites W2505868446 @default.
• W3216291274 cites W2576388508 @default.
• W3216291274 cites W2606996325 @default.
• W3216291274 cites W2621876443 @default.
• W3216291274 cites W2741375122 @default.
• W3216291274 cites W2781525129 @default.
• W3216291274 cites W2887164775 @default.
• W3216291274 cites W2898943230 @default.
• W3216291274 cites W2903623792 @default.
• W3216291274 cites W2968911253 @default.
• W3216291274 cites W2997280804 @default.
• W3216291274 cites W4234842417 @default.
• W3216291274 doi "https://doi.org/10.1001/jamaoncol.2021.5407" @default.
• W3216291274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34854874" @default.
• W3216291274 hasPublicationYear "2022" @default.
• W3216291274 type Work @default.
• W3216291274 sameAs 3216291274 @default.
• W3216291274 citedByCount "6" @default.
• W3216291274 countsByYear W32162912742022 @default.
• W3216291274 countsByYear W32162912742023 @default.
• W3216291274 crossrefType "journal-article" @default.
• W3216291274 hasAuthorship W3216291274A5009699993 @default.
• W3216291274 hasAuthorship W3216291274A5039136616 @default.
• W3216291274 hasAuthorship W3216291274A5047496278 @default.
• W3216291274 hasAuthorship W3216291274A5049946592 @default.
• W3216291274 hasAuthorship W3216291274A5053848207 @default.
• W3216291274 hasAuthorship W3216291274A5088893766 @default.
• W3216291274 hasBestOaLocation W32162912742 @default.
• W3216291274 hasConcept C121608353 @default.
• W3216291274 hasConcept C126322002 @default.
• W3216291274 hasConcept C143998085 @default.
• W3216291274 hasConcept C146357865 @default.
• W3216291274 hasConcept C151730666 @default.
• W3216291274 hasConcept C167135981 @default.
• W3216291274 hasConcept C187960798 @default.
• W3216291274 hasConcept C207103383 @default.
• W3216291274 hasConcept C2778764654 @default.
• W3216291274 hasConcept C2778975757 @default.
• W3216291274 hasConcept C2780210213 @default.
• W3216291274 hasConcept C2992026798 @default.
• W3216291274 hasConcept C44249647 @default.
• W3216291274 hasConcept C50382708 @default.
• W3216291274 hasConcept C71924100 @default.
• W3216291274 hasConcept C72563966 @default.
• W3216291274 hasConcept C86803240 @default.
• W3216291274 hasConcept C95190672 @default.
• W3216291274 hasConceptScore W3216291274C121608353 @default.
• W3216291274 hasConceptScore W3216291274C126322002 @default.
• W3216291274 hasConceptScore W3216291274C143998085 @default.
• W3216291274 hasConceptScore W3216291274C146357865 @default.
• W3216291274 hasConceptScore W3216291274C151730666 @default.
• W3216291274 hasConceptScore W3216291274C167135981 @default.
• W3216291274 hasConceptScore W3216291274C187960798 @default.
• W3216291274 hasConceptScore W3216291274C207103383 @default.
• W3216291274 hasConceptScore W3216291274C2778764654 @default.
• W3216291274 hasConceptScore W3216291274C2778975757 @default.
• W3216291274 hasConceptScore W3216291274C2780210213 @default.
• W3216291274 hasConceptScore W3216291274C2992026798 @default.
• W3216291274 hasConceptScore W3216291274C44249647 @default.
• W3216291274 hasConceptScore W3216291274C50382708 @default.
• W3216291274 hasConceptScore W3216291274C71924100 @default.
• W3216291274 hasConceptScore W3216291274C72563966 @default.

• next