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- W3216304210 abstract "Due to the multifunctionality of bone within the body, developing an appropriate material for therapy or transplantation is a challenge. Thus, many criteria must be considered when designing an engineered bone tissue construct, including the native properties and characteristics of bone. Also important is understanding the mediators who create, regulate, and remodel bone tissue: the bone cells and their lineages. Once materials capable of replicating bone structure, composition, mechanics, and biology are identified, additional design considerations are included. Cell-material interactions provide important cues for bone tissue processes, and it is necessary to consider ways to design for them. Additionally, the biological properties of a material are critical factors in bone tissue engineering (BTE) scaffold design to promote clinical translation. Design considerations to ensure biocompatibility, vascularization, and bone remodeling are often necessary additions when developing BTE constructs. The current material approaches for state-of-the-art BTE technologies will be evaluated in greater detail for ceramic and polymeric material systems. In general, ceramic materials provide mechanical robustness, however, fragility is a challenge. Polymeric materials, both natural and synthetic, have also been used. Natural polymers offer many advantages including biocompatibility, reduced immunogenicity, and bioactivity, but have poor mechanical properties, high production cost, and batch-to-batch variability. Synthetic polymers significantly improve mechanical strength, tunability, and throughput capabilities, but are limited by reduced bioactivity. Lastly, the preclinical translation of materials to be used for biological systems is considered. This chapter will examine in further detail (1) the material and biological properties of bone, (2) design considerations for BTE, (3) material approaches for BTE, and (4) preclinical translation considerations for constructs." @default.
- W3216304210 created "2021-12-06" @default.
- W3216304210 creator A5036162806 @default.
- W3216304210 creator A5040838186 @default.
- W3216304210 creator A5052100906 @default.
- W3216304210 creator A5063000820 @default.
- W3216304210 date "2022-01-01" @default.
- W3216304210 modified "2023-10-13" @default.
- W3216304210 title "Bone tissue engineering" @default.
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