FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216356670> ?p ?o ?g. }

• W3216356670 endingPage "1783" @default.
• W3216356670 startingPage "1769" @default.
• W3216356670 abstract "Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, and women account for 60% of diagnosed cases. β-Amyloid (Aβ) oligomers are considered the principal neurotoxic species in AD brains. The M1 muscarinic ACh receptor (M1 mAChR) plays a key role in memory and learning. M1 mAChR agonists show pro-cognitive activity but cause many adverse off-target effects. A new orally bioavailable M1 mAChR positive allosteric modulator (PAM), VU0486846, is devoid of direct agonist activity or adverse effects but was not tested for disease-modifying efficacy in female AD mice.Nine-month-old female APPswe/PSEN1ΔE9 (APPswe) and wildtype mice were treated with VU0486846 in drinking water (10 mg·kg-1 ·day-1 ) for 4 or 8 weeks. Cognitive function of mice was assessed after treatment, and brains were harvested for biochemical and immunohistochemical assessment.VU0486846 improved cognitive function of APPswe mice when tested in novel object recognition and Morris water maze. This was paralleled by a significant reduction in Aβ oligomers and plaques and neuronal loss in the hippocampus. VU0486846 reduced Aβ oligomer production in APPswe mice by increasing M1 mAChR expression and shifting the processing of amyloid precursor protein from amyloidogenic cleavage to non-amyloidogenic cleavage. Specifically, VU0486846 reduced the expression of β-secretase 1 (BACE1), whereas it enhanced the expression of the α-secretase ADAM10 in APPswe hippocampus.Using M1 mAChR PAMs can be a viable disease-modifying approach that should be exploited clinically to slow AD in women." @default.
• W3216356670 created "2021-12-06" @default.
• W3216356670 creator A5049414281 @default.
• W3216356670 creator A5055324773 @default.
• W3216356670 creator A5055889724 @default.
• W3216356670 creator A5071625081 @default.
• W3216356670 date "2022-02-03" @default.
• W3216356670 modified "2023-10-15" @default.
• W3216356670 title "A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female <scp>APPswe</scp>/PSEN1ΔE9 mice" @default.
• W3216356670 cites W1563974588 @default.
• W3216356670 cites W1835461481 @default.
• W3216356670 cites W1874938414 @default.
• W3216356670 cites W1977892449 @default.
• W3216356670 cites W1978106990 @default.
• W3216356670 cites W1987015236 @default.
• W3216356670 cites W2002948927 @default.
• W3216356670 cites W2003655335 @default.
• W3216356670 cites W2004513773 @default.
• W3216356670 cites W2006909079 @default.
• W3216356670 cites W2030722521 @default.
• W3216356670 cites W2035695460 @default.
• W3216356670 cites W2038421461 @default.
• W3216356670 cites W2039069312 @default.
• W3216356670 cites W2041196486 @default.
• W3216356670 cites W2041922642 @default.
• W3216356670 cites W2050330094 @default.
• W3216356670 cites W2053306852 @default.
• W3216356670 cites W2061342941 @default.
• W3216356670 cites W2067418199 @default.
• W3216356670 cites W2074940164 @default.
• W3216356670 cites W2075080836 @default.
• W3216356670 cites W2077225773 @default.
• W3216356670 cites W2102177106 @default.
• W3216356670 cites W2106162267 @default.
• W3216356670 cites W2120407369 @default.
• W3216356670 cites W2121987541 @default.
• W3216356670 cites W2128969673 @default.
• W3216356670 cites W2129085204 @default.
• W3216356670 cites W2130141176 @default.
• W3216356670 cites W2142943752 @default.
• W3216356670 cites W2148050426 @default.
• W3216356670 cites W2150063046 @default.
• W3216356670 cites W2313725855 @default.
• W3216356670 cites W2408135212 @default.
• W3216356670 cites W2479999044 @default.
• W3216356670 cites W2498452211 @default.
• W3216356670 cites W2557590069 @default.
• W3216356670 cites W2563344240 @default.
• W3216356670 cites W2566201294 @default.
• W3216356670 cites W2589774909 @default.
• W3216356670 cites W2594168808 @default.
• W3216356670 cites W2734651019 @default.
• W3216356670 cites W2765153686 @default.
• W3216356670 cites W2780161207 @default.
• W3216356670 cites W2790220887 @default.
• W3216356670 cites W2791419854 @default.
• W3216356670 cites W2791870770 @default.
• W3216356670 cites W2792530460 @default.
• W3216356670 cites W2801645749 @default.
• W3216356670 cites W2803433687 @default.
• W3216356670 cites W2805882949 @default.
• W3216356670 cites W2883785274 @default.
• W3216356670 cites W2907547898 @default.
• W3216356670 cites W2917273531 @default.
• W3216356670 cites W2921565126 @default.
• W3216356670 cites W2944862235 @default.
• W3216356670 cites W2965717703 @default.
• W3216356670 cites W2987960305 @default.
• W3216356670 cites W3003171737 @default.
• W3216356670 cites W3011757595 @default.
• W3216356670 cites W3042519295 @default.
• W3216356670 cites W3112500535 @default.
• W3216356670 cites W3165775737 @default.
• W3216356670 cites W3200835534 @default.
• W3216356670 cites W3200889336 @default.
• W3216356670 cites W4236357753 @default.
• W3216356670 doi "https://doi.org/10.1111/bph.15750" @default.
• W3216356670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34820835" @default.
• W3216356670 hasPublicationYear "2022" @default.
• W3216356670 type Work @default.
• W3216356670 sameAs 3216356670 @default.
• W3216356670 citedByCount "10" @default.
• W3216356670 countsByYear W32163566702022 @default.
• W3216356670 countsByYear W32163566702023 @default.
• W3216356670 crossrefType "journal-article" @default.
• W3216356670 hasAuthorship W3216356670A5049414281 @default.
• W3216356670 hasAuthorship W3216356670A5055324773 @default.
• W3216356670 hasAuthorship W3216356670A5055889724 @default.
• W3216356670 hasAuthorship W3216356670A5071625081 @default.
• W3216356670 hasBestOaLocation W32163566701 @default.
• W3216356670 hasConcept C109523444 @default.
• W3216356670 hasConcept C12515866 @default.
• W3216356670 hasConcept C126322002 @default.
• W3216356670 hasConcept C134018914 @default.
• W3216356670 hasConcept C15744967 @default.
• W3216356670 hasConcept C169760540 @default.
• W3216356670 hasConcept C170493617 @default.
• W3216356670 hasConcept C185592680 @default.

• next