FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216392317> ?p ?o ?g. }

• W3216392317 endingPage "1851" @default.
• W3216392317 startingPage "1851" @default.
• W3216392317 abstract "In the late phase of Trypanosoma cruzi infection, parasite persistence and an exaggerated immune response accompanied by oxidative stress play a crucial role in the genesis of Chronic Chagasic Cardiomyopathy (CCC). Current treatments (Benznidazole (BNZ) and Nifurtimox) can effect only the elimination of the parasite, but are ineffective for late stage treatment and for preventing heart damage and disease progression. In vivo trypanocidal and cardioprotective activity has been reported for Lippia alba essential oils (EOs), ascribed to their two major terpenes, limonene and caryophyllene oxide. To investigate the role of antioxidant and immunomodulatory mechanisms behind these properties, chronic-T. cruzi-infected rats were treated with oral synergistic mixtures of the aforementioned EOs. For this purpose, the EOs were optimized through limonene-enrichment fractioning and by the addition of exogenous caryophyllene oxide (LIMOX) and used alone or in combined therapy with subtherapeutic doses of BNZ (LIMOXBNZ). Clinical, toxicity, inflammatory, oxidative, and parasitological (qPCR) parameters were assessed in cardiac tissue. These therapies demonstrated meaningful antioxidant and immunomodulatory activity on markers involved in CCC pathogenesis (IFN-γ, TNF-α, IL-4, IL-10, and iNOS), which could explain their significant trypanocidal properties and their noteworthy role in preventing, and even reversing, the progression of cardiac damage in chronic Chagas disease." @default.
• W3216392317 created "2021-12-06" @default.
• W3216392317 creator A5037285612 @default.
• W3216392317 creator A5049669588 @default.
• W3216392317 creator A5051545263 @default.
• W3216392317 creator A5058705651 @default.
• W3216392317 creator A5075733544 @default.
• W3216392317 creator A5079922064 @default.
• W3216392317 creator A5088134696 @default.
• W3216392317 date "2021-11-22" @default.
• W3216392317 modified "2023-10-17" @default.
• W3216392317 title "Immunomodulation and Antioxidant Activities as Possible Trypanocidal and Cardioprotective Mechanisms of Major Terpenes from Lippia alba Essential Oils in an Experimental Model of Chronic Chagas Disease" @default.
• W3216392317 cites W1566992315 @default.
• W3216392317 cites W1998322948 @default.
• W3216392317 cites W2020259352 @default.
• W3216392317 cites W2109088899 @default.
• W3216392317 cites W2134329032 @default.
• W3216392317 cites W2134465902 @default.
• W3216392317 cites W2135370680 @default.
• W3216392317 cites W2164581520 @default.
• W3216392317 cites W2167755309 @default.
• W3216392317 cites W2322471444 @default.
• W3216392317 cites W2603767264 @default.
• W3216392317 cites W2763660888 @default.
• W3216392317 cites W2772065837 @default.
• W3216392317 cites W2793817241 @default.
• W3216392317 cites W2801101174 @default.
• W3216392317 cites W2883864384 @default.
• W3216392317 cites W2886874261 @default.
• W3216392317 cites W2898556213 @default.
• W3216392317 cites W2900384526 @default.
• W3216392317 cites W2902847939 @default.
• W3216392317 cites W2913010358 @default.
• W3216392317 cites W2952481429 @default.
• W3216392317 cites W307879936 @default.
• W3216392317 cites W3112217018 @default.
• W3216392317 cites W3154674617 @default.
• W3216392317 cites W3157297365 @default.
• W3216392317 cites W4296190548 @default.
• W3216392317 doi "https://doi.org/10.3390/antiox10111851" @default.
• W3216392317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8614928" @default.
• W3216392317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34829722" @default.
• W3216392317 hasPublicationYear "2021" @default.
• W3216392317 type Work @default.
• W3216392317 sameAs 3216392317 @default.
• W3216392317 citedByCount "3" @default.
• W3216392317 countsByYear W32163923172023 @default.
• W3216392317 crossrefType "journal-article" @default.
• W3216392317 hasAuthorship W3216392317A5037285612 @default.
• W3216392317 hasAuthorship W3216392317A5049669588 @default.
• W3216392317 hasAuthorship W3216392317A5051545263 @default.
• W3216392317 hasAuthorship W3216392317A5058705651 @default.
• W3216392317 hasAuthorship W3216392317A5075733544 @default.
• W3216392317 hasAuthorship W3216392317A5079922064 @default.
• W3216392317 hasAuthorship W3216392317A5088134696 @default.
• W3216392317 hasBestOaLocation W32163923171 @default.
• W3216392317 hasConcept C112418997 @default.
• W3216392317 hasConcept C136764020 @default.
• W3216392317 hasConcept C203014093 @default.
• W3216392317 hasConcept C2776134268 @default.
• W3216392317 hasConcept C2776151105 @default.
• W3216392317 hasConcept C2776171842 @default.
• W3216392317 hasConcept C2777278459 @default.
• W3216392317 hasConcept C2777625466 @default.
• W3216392317 hasConcept C2778004101 @default.
• W3216392317 hasConcept C41008148 @default.
• W3216392317 hasConcept C55493867 @default.
• W3216392317 hasConcept C556039675 @default.
• W3216392317 hasConcept C59822182 @default.
• W3216392317 hasConcept C71924100 @default.
• W3216392317 hasConcept C71928629 @default.
• W3216392317 hasConcept C86803240 @default.
• W3216392317 hasConcept C98274493 @default.
• W3216392317 hasConceptScore W3216392317C112418997 @default.
• W3216392317 hasConceptScore W3216392317C136764020 @default.
• W3216392317 hasConceptScore W3216392317C203014093 @default.
• W3216392317 hasConceptScore W3216392317C2776134268 @default.
• W3216392317 hasConceptScore W3216392317C2776151105 @default.
• W3216392317 hasConceptScore W3216392317C2776171842 @default.
• W3216392317 hasConceptScore W3216392317C2777278459 @default.
• W3216392317 hasConceptScore W3216392317C2777625466 @default.
• W3216392317 hasConceptScore W3216392317C2778004101 @default.
• W3216392317 hasConceptScore W3216392317C41008148 @default.
• W3216392317 hasConceptScore W3216392317C55493867 @default.
• W3216392317 hasConceptScore W3216392317C556039675 @default.
• W3216392317 hasConceptScore W3216392317C59822182 @default.
• W3216392317 hasConceptScore W3216392317C71924100 @default.
• W3216392317 hasConceptScore W3216392317C71928629 @default.
• W3216392317 hasConceptScore W3216392317C86803240 @default.
• W3216392317 hasConceptScore W3216392317C98274493 @default.
• W3216392317 hasIssue "11" @default.
• W3216392317 hasLocation W32163923171 @default.
• W3216392317 hasLocation W32163923172 @default.
• W3216392317 hasLocation W32163923173 @default.
• W3216392317 hasLocation W32163923174 @default.
• W3216392317 hasOpenAccess W3216392317 @default.
• W3216392317 hasPrimaryLocation W32163923171 @default.
• W3216392317 hasRelatedWork W2097044116 @default.

• next