FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216402825> ?p ?o ?g. }

• W3216402825 abstract "Abstract Background Immunotherapy is an important treatment in oncology, but only a fraction of patients with head and neck squamous cell carcinoma (HNSCC) benefit from it. Therefore, the aim of this study was to identify predictive biomarkers of immunotherapy response for HNSCC in order to improve treatment outcomes. Methods Survival analyses and comparative efficacy evaluation were performed to investigate prognostic and therapeutic impact factors in patients with advanced HNSCC following immunotherapy, and to examine the effects of factors including gene mutations, tumor mutational burden (TMB), mutant-allele tumor heterogeneity (MATH), and immune cell infiltration on the survival and efficacy. Results Anti-PD-1 treatment led to a prolonged overall survival (OS) in HNSCC patients with gene mutations compared with those without the mutations, while no significant difference in the OS was found between the two groups of patients. And no marked association between the MATH value and OS was detected in HNSCC patients, whereas patients with either high TMB scores in tissues and blood or high immune cell infiltration displayed a significantly longer OS. Further analysis with efficacy as the primary endpoint revealed no significant differences in the tissue TMB, blood TMB, and MATH value between the patients who responded to immunotherapy and those who did not. Moreover, no significant differences in the expression percentages of positive immune cells in tumor, stroma, and total regions were identified between the above two groups of patients. Conclusion HNSCC is characterized by high mutation rate, high mutation burden, and high level of immune cell infiltration, and a subset of HNSCC patients respond to immunotherapy. Here, we showed that high mutation burden and immune cell infiltration may improve the prognosis of HNSCC patients with immunotherapy, while there was no remarkable effect on the efficacy." @default.
• W3216402825 created "2021-12-06" @default.
• W3216402825 creator A5021541475 @default.
• W3216402825 creator A5025855204 @default.
• W3216402825 creator A5039841922 @default.
• W3216402825 creator A5046386679 @default.
• W3216402825 creator A5059063067 @default.
• W3216402825 creator A5073040773 @default.
• W3216402825 creator A5080852112 @default.
• W3216402825 date "2021-11-25" @default.
• W3216402825 modified "2023-09-23" @default.
• W3216402825 title "Identification of factors related to immunotherapy efficacy and prognosis in patients with advanced head and neck squamous cell carcinoma" @default.
• W3216402825 cites W1984068087 @default.
• W3216402825 cites W1985213644 @default.
• W3216402825 cites W1986241711 @default.
• W3216402825 cites W2108234281 @default.
• W3216402825 cites W2168133698 @default.
• W3216402825 cites W2282664279 @default.
• W3216402825 cites W2515212546 @default.
• W3216402825 cites W2537963082 @default.
• W3216402825 cites W2597872842 @default.
• W3216402825 cites W2614488762 @default.
• W3216402825 cites W2770543801 @default.
• W3216402825 cites W2788797147 @default.
• W3216402825 cites W2789325945 @default.
• W3216402825 cites W2791660360 @default.
• W3216402825 cites W2797675588 @default.
• W3216402825 cites W2799372507 @default.
• W3216402825 cites W2889646458 @default.
• W3216402825 cites W2890133814 @default.
• W3216402825 cites W2890180104 @default.
• W3216402825 cites W2899537750 @default.
• W3216402825 cites W2900082702 @default.
• W3216402825 cites W2903493423 @default.
• W3216402825 cites W2946204120 @default.
• W3216402825 cites W2965035617 @default.
• W3216402825 cites W2979141147 @default.
• W3216402825 cites W3082602047 @default.
• W3216402825 cites W3093398693 @default.
• W3216402825 cites W3112913477 @default.
• W3216402825 cites W3184900769 @default.
• W3216402825 doi "https://doi.org/10.1186/s13000-021-01147-7" @default.
• W3216402825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8620526" @default.
• W3216402825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34823553" @default.
• W3216402825 hasPublicationYear "2021" @default.
• W3216402825 type Work @default.
• W3216402825 sameAs 3216402825 @default.
• W3216402825 citedByCount "4" @default.
• W3216402825 countsByYear W32164028252022 @default.
• W3216402825 countsByYear W32164028252023 @default.
• W3216402825 crossrefType "journal-article" @default.
• W3216402825 hasAuthorship W3216402825A5021541475 @default.
• W3216402825 hasAuthorship W3216402825A5025855204 @default.
• W3216402825 hasAuthorship W3216402825A5039841922 @default.
• W3216402825 hasAuthorship W3216402825A5046386679 @default.
• W3216402825 hasAuthorship W3216402825A5059063067 @default.
• W3216402825 hasAuthorship W3216402825A5073040773 @default.
• W3216402825 hasAuthorship W3216402825A5080852112 @default.
• W3216402825 hasBestOaLocation W32164028251 @default.
• W3216402825 hasConcept C121608353 @default.
• W3216402825 hasConcept C126322002 @default.
• W3216402825 hasConcept C143998085 @default.
• W3216402825 hasConcept C203014093 @default.
• W3216402825 hasConcept C2776530083 @default.
• W3216402825 hasConcept C2776833033 @default.
• W3216402825 hasConcept C2777701055 @default.
• W3216402825 hasConcept C71924100 @default.
• W3216402825 hasConcept C8891405 @default.
• W3216402825 hasConceptScore W3216402825C121608353 @default.
• W3216402825 hasConceptScore W3216402825C126322002 @default.
• W3216402825 hasConceptScore W3216402825C143998085 @default.
• W3216402825 hasConceptScore W3216402825C203014093 @default.
• W3216402825 hasConceptScore W3216402825C2776530083 @default.
• W3216402825 hasConceptScore W3216402825C2776833033 @default.
• W3216402825 hasConceptScore W3216402825C2777701055 @default.
• W3216402825 hasConceptScore W3216402825C71924100 @default.
• W3216402825 hasConceptScore W3216402825C8891405 @default.
• W3216402825 hasIssue "1" @default.
• W3216402825 hasLocation W32164028251 @default.
• W3216402825 hasLocation W32164028252 @default.
• W3216402825 hasLocation W32164028253 @default.
• W3216402825 hasOpenAccess W3216402825 @default.
• W3216402825 hasPrimaryLocation W32164028251 @default.
• W3216402825 hasRelatedWork W1996158748 @default.
• W3216402825 hasRelatedWork W2112256663 @default.
• W3216402825 hasRelatedWork W2770543801 @default.
• W3216402825 hasRelatedWork W3012537123 @default.
• W3216402825 hasRelatedWork W3018127538 @default.
• W3216402825 hasRelatedWork W3081408373 @default.
• W3216402825 hasRelatedWork W3167681251 @default.
• W3216402825 hasRelatedWork W3203604538 @default.
• W3216402825 hasRelatedWork W4248668835 @default.
• W3216402825 hasRelatedWork W4284972867 @default.
• W3216402825 hasVolume "16" @default.
• W3216402825 isParatext "false" @default.
• W3216402825 isRetracted "false" @default.
• W3216402825 magId "3216402825" @default.
• W3216402825 workType "article" @default.