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• W3216406977 endingPage "116521" @default.
• W3216406977 startingPage "116521" @default.
• W3216406977 abstract "Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes were designed as potential HSP90 inhibitors. A series of the compounds was synthesized by oximation of (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-ones followed by O-acylation with acylamidobenzoic acids. The obtained compounds showed an antiproliferative effect on three breast cancer cell lines (MCF7, MDA-MB-231 and HCC1954). Compound 16s exhibited high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM was selected for in-depth evaluation. Compound 16s did not inhibit the growth of normal epithelial cells. We have demonstrated that the compound 16s can induce apoptosis in cancer cells via inhibition of HSP90 client proteins including a key oncogenic receptor, HER2/neu. Described here compounds can be considered for further basic and preclinical investigation as a part of HSP90/HER2-targeted therapies." @default.
• W3216406977 created "2021-12-06" @default.
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• W3216406977 date "2022-01-01" @default.
• W3216406977 modified "2023-09-26" @default.
• W3216406977 title "Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells" @default.
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• W3216406977 doi "https://doi.org/10.1016/j.bmc.2021.116521" @default.
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• W3216406977 hasPublicationYear "2022" @default.
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