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- W3216449772 abstract "The Japanese Epidemiological Study on Low-Dose Radiation Effects (J-EPISODE) has been conducted since 1990 by the Radiation Effects Association to analyse health effects for nuclear workers. It uses the recorded doses, i.e. dosimeter readings, evaluated inHp(10) for estimation of radiation risk; however, the International Commission on Radiological Protection does not recommend the use of effective doses for epidemiological evaluation and instead recommends the use of organ-absorbed doses for assessing cancer risk. Recently, the J-EPISODE has developed a conversion factor that can convert dosimeter readings to organ-absorbed doses following, in principle, the approach adopted by the International Agency for Research on Cancer 15-Country Collaborative Study. The approach was modified based on recent dosimeter usage practices and the Japanese physique. The aim of this study was to reanalyse the excess relative risk (ERR) of cancer mortality for the J-EPISODE using the previous analysis method but substituting the organ-absorbed dose for the recorded dose to confirm the adaptability and relevance of organ-absorbed doses for the J-EPISODE. The organ-absorbed doses from 1957 to 2010 were reconstructed for the whole cohort. The cancer mortality risk was reanalysed with Poisson regression methods, first by comparing the ERR/Gy for all cancers excluding leukaemia with the risk after excluding lung cancer for the whole cohort of 204 103 participants. In the whole cohort, all cancers excluding leukaemia, lung cancer and non-Hodgkin's lymphoma had statistically significant positive ERR/Gy estimates; leukaemia excluding chronic lymphocytic leukaemia had negative but not statistically significant estimates. Gallbladder cancer and pancreatic cancer showed statistically significant negative. Then, a subcohort of 71 733 respondents was selected based on lifestyle surveys with data on qualitative smoking status as well as quantitative smoking information on pack-years. Pack-years for current smokers and former smokers and years since the cessation of smoking for former smokers were used for the smoking-adjusted model. The most important feature of the J-EPISODE revealed to date was a decreasing tendency of the ERR/Sv by the smoking adjustment. For almost all causes of death such as lung cancer and stomach cancer, the estimated ERR/Gy decreased by the smoking adjustment, although those for the colon, prostate and kidney and other urinary organs were almost the same after the adjustment. This tendency remained unchanged even when using the organ-absorbed dose, indicating the appropriateness of using organ-absorbed doses for further risk analysis. At the same time, it indicated that confounding by smoking seriously biased the radiation risk estimates in the J-EPISODE and thus should be accounted even if organ dose is used." @default.
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- W3216449772 date "2022-01-18" @default.
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- W3216449772 title "Reanalysis of cancer mortality using reconstructed organ-absorbed dose: J-EPISODE 1991‒2010" @default.
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- W3216449772 doi "https://doi.org/10.1088/1361-6498/ac3bc5" @default.
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