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- W3216457585 endingPage "220" @default.
- W3216457585 startingPage "206" @default.
- W3216457585 abstract "Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM). While the physiological function of BAX ensures tissue homeostasis, dysregulation of BAX leads to aberrant cell death. Despite BAX being a promising therapeutic target for human diseases, historically the development of drugs has focused on antiapoptotic BCL-2 proteins, due to challenges in elucidating the mechanism of BAX activation and identifying druggable surfaces of BAX. Here, we discuss recent studies that have provided structure-function insights and identified regulatory surfaces that control BAX activation. Moreover, we emphasize the development of small molecule orthosteric, allosteric, and oligomerization modulators that provide novel opportunities for biological investigation and progress towards drugging BAX." @default.
- W3216457585 created "2021-12-06" @default.
- W3216457585 creator A5029154431 @default.
- W3216457585 creator A5032989019 @default.
- W3216457585 date "2022-03-01" @default.
- W3216457585 modified "2023-10-17" @default.
- W3216457585 title "Physiological and pharmacological modulation of BAX" @default.
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- W3216457585 doi "https://doi.org/10.1016/j.tips.2021.11.001" @default.
- W3216457585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34848097" @default.
- W3216457585 hasPublicationYear "2022" @default.
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