FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216463961> ?p ?o ?g. }

• W3216463961 endingPage "6031" @default.
• W3216463961 startingPage "6031" @default.
• W3216463961 abstract "Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that is dysregulated by poor prenatal nutrition and environmental toxins. KCNK9 encodes for TASK3, a pH-regulated potassium channel membrane protein that is overexpressed in 40% of breast cancer. However, KCNK9 gene amplification accounts for increased expression in <10% of these breast cancers. Here, we showed that KCNK9 is imprinted in breast tissue and identified a differentially methylated region (DMR) controlling its imprint status. Hypomethylation at the DMR, coupled with biallelic expression of KCNK9, occurred in 63% of triple-negative breast cancers (TNBC). The association between hypomethylation and TNBC status was highly significant in African-Americans (p = 0.006), but not in Caucasians (p = 0.70). KCNK9 hypomethylation was also found in non-cancerous tissue from 77% of women at high-risk of developing breast cancer. Functional studies demonstrated that the KCNK9 gene product, TASK3, regulates mitochondrial membrane potential and apoptosis-sensitivity. In TNBC cells and non-cancerous mammary epithelial cells from high-risk women, hypomethylation of the KCNK9 DMR predicts for increased TASK3 expression and mitochondrial membrane potential (p < 0.001). This is the first identification of the KCNK9 DMR in mammary epithelial cells and demonstration that its hypomethylation in breast cancer is associated with increases in both mitochondrial membrane potential and apoptosis resistance. The high frequency of hypomethylation of the KCNK9 DMR in TNBC and non-cancerous breast tissue from high-risk women provides evidence that hypomethylation of the KNCK9 DMR/TASK3 overexpression may serve as a marker of risk and a target for prevention of TNBC, particularly in African American women." @default.
• W3216463961 created "2021-12-06" @default.
• W3216463961 creator A5000359290 @default.
• W3216463961 creator A5007126253 @default.
• W3216463961 creator A5013679644 @default.
• W3216463961 creator A5014398148 @default.
• W3216463961 creator A5015702164 @default.
• W3216463961 creator A5016220011 @default.
• W3216463961 creator A5021530808 @default.
• W3216463961 creator A5023102311 @default.
• W3216463961 creator A5029813414 @default.
• W3216463961 creator A5061721402 @default.
• W3216463961 creator A5071074432 @default.
• W3216463961 creator A5076846225 @default.
• W3216463961 creator A5080229565 @default.
• W3216463961 creator A5080840214 @default.
• W3216463961 creator A5083407868 @default.
• W3216463961 date "2021-11-30" @default.
• W3216463961 modified "2023-09-23" @default.
• W3216463961 title "Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer" @default.
• W3216463961 cites W1594472165 @default.
• W3216463961 cites W1852482464 @default.
• W3216463961 cites W1919614031 @default.
• W3216463961 cites W1963735070 @default.
• W3216463961 cites W1964124586 @default.
• W3216463961 cites W1971708895 @default.
• W3216463961 cites W1984519311 @default.
• W3216463961 cites W2007576179 @default.
• W3216463961 cites W2008945055 @default.
• W3216463961 cites W2009940298 @default.
• W3216463961 cites W2015777649 @default.
• W3216463961 cites W2018647656 @default.
• W3216463961 cites W2019689602 @default.
• W3216463961 cites W2021364153 @default.
• W3216463961 cites W2029179317 @default.
• W3216463961 cites W2032788228 @default.
• W3216463961 cites W2033102369 @default.
• W3216463961 cites W2036764668 @default.
• W3216463961 cites W2044124160 @default.
• W3216463961 cites W2046754336 @default.
• W3216463961 cites W2049111285 @default.
• W3216463961 cites W2051292461 @default.
• W3216463961 cites W2063744866 @default.
• W3216463961 cites W2064738170 @default.
• W3216463961 cites W2075057742 @default.
• W3216463961 cites W2076472141 @default.
• W3216463961 cites W2093056723 @default.
• W3216463961 cites W2118090408 @default.
• W3216463961 cites W2123021448 @default.
• W3216463961 cites W2128016314 @default.
• W3216463961 cites W2129246334 @default.
• W3216463961 cites W2136145671 @default.
• W3216463961 cites W2139634734 @default.
• W3216463961 cites W2144258002 @default.
• W3216463961 cites W2144673609 @default.
• W3216463961 cites W2146734921 @default.
• W3216463961 cites W2150660418 @default.
• W3216463961 cites W2160024356 @default.
• W3216463961 cites W2166389246 @default.
• W3216463961 cites W2171538603 @default.
• W3216463961 cites W2323894910 @default.
• W3216463961 cites W2335704194 @default.
• W3216463961 cites W2337364339 @default.
• W3216463961 cites W2782069931 @default.
• W3216463961 cites W3111771168 @default.
• W3216463961 cites W33922267 @default.
• W3216463961 doi "https://doi.org/10.3390/cancers13236031" @default.
• W3216463961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34885139" @default.
• W3216463961 hasPublicationYear "2021" @default.
• W3216463961 type Work @default.
• W3216463961 sameAs 3216463961 @default.
• W3216463961 citedByCount "1" @default.
• W3216463961 countsByYear W32164639612023 @default.
• W3216463961 crossrefType "journal-article" @default.
• W3216463961 hasAuthorship W3216463961A5000359290 @default.
• W3216463961 hasAuthorship W3216463961A5007126253 @default.
• W3216463961 hasAuthorship W3216463961A5013679644 @default.
• W3216463961 hasAuthorship W3216463961A5014398148 @default.
• W3216463961 hasAuthorship W3216463961A5015702164 @default.
• W3216463961 hasAuthorship W3216463961A5016220011 @default.
• W3216463961 hasAuthorship W3216463961A5021530808 @default.
• W3216463961 hasAuthorship W3216463961A5023102311 @default.
• W3216463961 hasAuthorship W3216463961A5029813414 @default.
• W3216463961 hasAuthorship W3216463961A5061721402 @default.
• W3216463961 hasAuthorship W3216463961A5071074432 @default.
• W3216463961 hasAuthorship W3216463961A5076846225 @default.
• W3216463961 hasAuthorship W3216463961A5080229565 @default.
• W3216463961 hasAuthorship W3216463961A5080840214 @default.
• W3216463961 hasAuthorship W3216463961A5083407868 @default.
• W3216463961 hasBestOaLocation W32164639611 @default.
• W3216463961 hasConcept C104317684 @default.
• W3216463961 hasConcept C121608353 @default.
• W3216463961 hasConcept C150194340 @default.
• W3216463961 hasConcept C190727270 @default.
• W3216463961 hasConcept C201492766 @default.
• W3216463961 hasConcept C2780110267 @default.
• W3216463961 hasConcept C41091548 @default.
• W3216463961 hasConcept C502942594 @default.

• next