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- W3216479121 abstract "In the present work, we have synthesized novel quinoline-conjugated 1,2,3-triazole derivatives 6a–l starting from substituted acetanilides in five steps. The synthesized compounds were screened for their antileishmanial activity. Quinoline-conjugated 1,2,3-triazole compounds 6c (IC50 = 15.1 μg/ml), 6d (IC50 = 14.6 μg/ml) and 6e (IC50 = 14.3 μg/ml) displayed potent antileishmanial activity when compared with standard sodium stibogluconate (IC50 = 14.3 ± 1.5 μg/ml). A molecular docking study against Leishmania major pteridine reductase (Lm-PTR1) suggests that these compounds have the potential to become lead molecules in antileishmanial drug discovery." @default.
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- W3216479121 date "2021-12-12" @default.
- W3216479121 modified "2023-10-01" @default.
- W3216479121 title "Synthesis, Biological Evaluation and Molecular Docking Studies of Quinoline‐conjugated 1,2, 3‐Triazole Derivatives as Antileishmanial Agents" @default.
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- W3216479121 doi "https://doi.org/10.1002/jhet.4414" @default.
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