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- W3216518545 abstract "The identification of the major target antigen phospholipase A2 receptor (PLA2R) in the majority of primary (idiopathic) cases of membranous nephropathy (MN) has been followed by the rapid identification of numerous minor antigens that appear to define phenotypically distinct forms of disease. This article serves to review all the known antigens that have been shown to localize to subepithelial deposits in MN, as well as the distinctive characteristics associated with each subtype of MN. We will also shed light on the novel proteomic approaches that have allowed identification of the most recent antigens. The paradigm of an antigen normally expressed on the podocyte cell surface leading to in-situ immune complex formation, complement activation, and subsequent podocyte injury will be discussed and challenged in light of the current repertoire of multiple MN antigens. Since disease phenotypes associated with each individual target antigens can often blur the distinction between primary and secondary disease, we encourage the use of antigen-based classification of membranous nephropathy." @default.
- W3216518545 created "2021-12-06" @default.
- W3216518545 creator A5004456379 @default.
- W3216518545 creator A5048103077 @default.
- W3216518545 creator A5057529489 @default.
- W3216518545 date "2021-11-26" @default.
- W3216518545 modified "2023-10-02" @default.
- W3216518545 title "How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy" @default.
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