Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216554547> ?p ?o ?g. }
- W3216554547 abstract "Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat dysfunction. This process is regulated by the interaction of epigenetic pathways involving histone and DNA methylation. In mature brown adipocytes, the histone demethylase UTX maintains persistent demethylation of the repressive mark H3K27me3 at Prdm16 promoter, leading to high Prdm16 expression. PRDM16 then recruits DNA methyltransferase DNMT1 to Myod1 promoter, causing Myod1 promoter hypermethylation and suppressing its expression. The interaction between PRDM16 and DNMT1 coordinately serves to maintain brown adipocyte identity while repressing myogenic remodeling in mature brown adipocytes, thus promoting their active brown adipocyte thermogenic function. Suppressing this interaction by HFD feeding induces brown adipocyte-to-myocyte remodeling, which limits brown adipocyte thermogenic capacity and compromises diet-induced thermogenesis, leading to the development of obesity." @default.
- W3216554547 created "2021-12-06" @default.
- W3216554547 creator A5004110708 @default.
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- W3216554547 creator A5060816611 @default.
- W3216554547 creator A5063521272 @default.
- W3216554547 creator A5069227834 @default.
- W3216554547 date "2021-11-25" @default.
- W3216554547 modified "2023-10-16" @default.
- W3216554547 title "Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat" @default.
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