Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216575443> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3216575443 abstract "Introduction: Heart failure (HF) is characterized by metabolic inflexibility in fuel substrate selection and results in dysregulation of downstream mitochondrial processes. Prior work has identified greater plasma concentrations of circulating long-chain acylcarnitines (LCAC) in HF. LCAC are metabolites reporting on impaired mitochondrial fatty acid catabolism and predict incident adverse events in HF. Hypothesis: We hypothesized that a polygenic risk score (PRS) of genetic variation in mitochondrially-associated genes may be associated with circulating LCAC as well as HF phenotypes. Methods: The study population consisted of 2277 European-ancestry participants from the CATHGEN (CATHeterization GENetics) cohort, consisting of sequential individuals undergoing cardiac catheterization at Duke University. Using PRSice software, a PRS was generated from variants in 1462 nuclear genes implicated in mitochondrial function; weights were derived from the HERMES HF GWAS meta-analysis. Linear regression was used to test the association between the mitochondrial function PRS and plasma metabolite levels, as well as HF phenotypes, in models adjusting for ancestry principal components and batch. Results: The analysis cohort included 515 participants with HF, with 39% females and a mean age 61.2 11.8 years. The mitochondrial PRS was associated with three LCAC: C10, C10:1 and C12:1 (nominal p-values 0.02-0.008, 18-70 variants). The PRS was not associated with prevalent cardiomyopathy (p=0.097) or HF (p=0.16). Conclusions: We have generated a focused PRS inclusive of mitochondrial nuclear genetic variants weighted on HF association and found it to be associated with relevant circulating metabolites of mitochondrial fatty acid metabolism. These results highlight the utility of a novel biology-focused PRS in cardiovascular disease traits." @default.
- W3216575443 created "2021-12-06" @default.
- W3216575443 creator A5017226394 @default.
- W3216575443 creator A5019140441 @default.
- W3216575443 creator A5022951863 @default.
- W3216575443 creator A5030432698 @default.
- W3216575443 creator A5044894867 @default.
- W3216575443 creator A5055822075 @default.
- W3216575443 creator A5083259323 @default.
- W3216575443 date "2021-11-16" @default.
- W3216575443 modified "2023-09-24" @default.
- W3216575443 title "Abstract 13874: A Mitochondrial Polygenic Risk Score is Associated With Metabolite Levels Implicated in Heart Failure" @default.
- W3216575443 doi "https://doi.org/10.1161/circ.144.suppl_1.13874" @default.
- W3216575443 hasPublicationYear "2021" @default.
- W3216575443 type Work @default.
- W3216575443 sameAs 3216575443 @default.
- W3216575443 citedByCount "0" @default.
- W3216575443 crossrefType "journal-article" @default.
- W3216575443 hasAuthorship W3216575443A5017226394 @default.
- W3216575443 hasAuthorship W3216575443A5019140441 @default.
- W3216575443 hasAuthorship W3216575443A5022951863 @default.
- W3216575443 hasAuthorship W3216575443A5030432698 @default.
- W3216575443 hasAuthorship W3216575443A5044894867 @default.
- W3216575443 hasAuthorship W3216575443A5055822075 @default.
- W3216575443 hasAuthorship W3216575443A5083259323 @default.
- W3216575443 hasConcept C126322002 @default.
- W3216575443 hasConcept C134018914 @default.
- W3216575443 hasConcept C2777477808 @default.
- W3216575443 hasConcept C2778198053 @default.
- W3216575443 hasConcept C2908647359 @default.
- W3216575443 hasConcept C42407357 @default.
- W3216575443 hasConcept C54355233 @default.
- W3216575443 hasConcept C71924100 @default.
- W3216575443 hasConcept C72563966 @default.
- W3216575443 hasConcept C86803240 @default.
- W3216575443 hasConcept C99454951 @default.
- W3216575443 hasConceptScore W3216575443C126322002 @default.
- W3216575443 hasConceptScore W3216575443C134018914 @default.
- W3216575443 hasConceptScore W3216575443C2777477808 @default.
- W3216575443 hasConceptScore W3216575443C2778198053 @default.
- W3216575443 hasConceptScore W3216575443C2908647359 @default.
- W3216575443 hasConceptScore W3216575443C42407357 @default.
- W3216575443 hasConceptScore W3216575443C54355233 @default.
- W3216575443 hasConceptScore W3216575443C71924100 @default.
- W3216575443 hasConceptScore W3216575443C72563966 @default.
- W3216575443 hasConceptScore W3216575443C86803240 @default.
- W3216575443 hasConceptScore W3216575443C99454951 @default.
- W3216575443 hasIssue "Suppl_1" @default.
- W3216575443 hasLocation W32165754431 @default.
- W3216575443 hasOpenAccess W3216575443 @default.
- W3216575443 hasPrimaryLocation W32165754431 @default.
- W3216575443 hasRelatedWork W1966504330 @default.
- W3216575443 hasRelatedWork W1966775726 @default.
- W3216575443 hasRelatedWork W1974041167 @default.
- W3216575443 hasRelatedWork W1979139803 @default.
- W3216575443 hasRelatedWork W2030889776 @default.
- W3216575443 hasRelatedWork W2037631372 @default.
- W3216575443 hasRelatedWork W2040058909 @default.
- W3216575443 hasRelatedWork W2132898409 @default.
- W3216575443 hasRelatedWork W2748952813 @default.
- W3216575443 hasRelatedWork W4249176446 @default.
- W3216575443 hasVolume "144" @default.
- W3216575443 isParatext "false" @default.
- W3216575443 isRetracted "false" @default.
- W3216575443 magId "3216575443" @default.
- W3216575443 workType "article" @default.