FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216593905> ?p ?o ?g. }

• W3216593905 endingPage "101276" @default.
• W3216593905 startingPage "101276" @default.
• W3216593905 abstract "The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing in relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups and ancestries could play an essential role in developing this molecular alteration within lung cancer.In a prospective and retrospective cohort study on samples from lung adenocarcinoma from 1000 patients from different administrative regions in Colombia were tested for the KRAS p.G12C mutation. An analysis of STR populations markers was conducted to identify substructure contributions to mutation prevalence.Included were 979 patients with a national mean frequency for the KRAS exon 2 p.G12C mutation of 7.97% (95%CI 6.27-9.66%). Variation between regions was also identified with Antioquia reaching a positivity value of 12.7% (95%CI 9.1-16.3%) in contrast to other regions such as Bogota DC (Capital region) with 5.4% (2.7-8.2%) and Bolivar with 2.4% (95%CI 0-7.2%) (p-value = 0.00262). Furthermore, Short tandem repeat population substructures were found for eight markers that strongly yielded association with KRAS exon 2 p.G12C frequency reaching an adjusted R2 of 0.945 and a p-value of < 0.0001.Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be easily determined by population and ancestral markers such as STR." @default.
• W3216593905 created "2021-12-06" @default.
• W3216593905 creator A5000631349 @default.
• W3216593905 creator A5003304508 @default.
• W3216593905 creator A5008894786 @default.
• W3216593905 creator A5012567937 @default.
• W3216593905 creator A5014453416 @default.
• W3216593905 creator A5017550861 @default.
• W3216593905 creator A5017669867 @default.
• W3216593905 creator A5017769557 @default.
• W3216593905 creator A5020080512 @default.
• W3216593905 creator A5022841989 @default.
• W3216593905 creator A5034618792 @default.
• W3216593905 creator A5035063101 @default.
• W3216593905 creator A5038974897 @default.
• W3216593905 creator A5039140100 @default.
• W3216593905 creator A5041934777 @default.
• W3216593905 creator A5042574444 @default.
• W3216593905 creator A5044612760 @default.
• W3216593905 creator A5044887899 @default.
• W3216593905 creator A5047294452 @default.
• W3216593905 creator A5048183782 @default.
• W3216593905 creator A5057297789 @default.
• W3216593905 creator A5058117531 @default.
• W3216593905 creator A5060388485 @default.
• W3216593905 creator A5065133327 @default.
• W3216593905 creator A5068440395 @default.
• W3216593905 creator A5070081985 @default.
• W3216593905 creator A5071235015 @default.
• W3216593905 creator A5072569354 @default.
• W3216593905 creator A5074835287 @default.
• W3216593905 creator A5082876643 @default.
• W3216593905 creator A5089271375 @default.
• W3216593905 date "2022-01-01" @default.
• W3216593905 modified "2023-10-17" @default.
• W3216593905 title "p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics" @default.
• W3216593905 cites W1599750485 @default.
• W3216593905 cites W2005312471 @default.
• W3216593905 cites W2040178944 @default.
• W3216593905 cites W2119723981 @default.
• W3216593905 cites W2122133689 @default.
• W3216593905 cites W2129590156 @default.
• W3216593905 cites W2149588035 @default.
• W3216593905 cites W2180481128 @default.
• W3216593905 cites W2320138981 @default.
• W3216593905 cites W2481432687 @default.
• W3216593905 cites W2526607882 @default.
• W3216593905 cites W2604833683 @default.
• W3216593905 cites W2736963305 @default.
• W3216593905 cites W2767162493 @default.
• W3216593905 cites W2792305684 @default.
• W3216593905 cites W2909800464 @default.
• W3216593905 cites W2921494668 @default.
• W3216593905 cites W2982321167 @default.
• W3216593905 cites W3001127305 @default.
• W3216593905 cites W3031050632 @default.
• W3216593905 cites W3087229737 @default.
• W3216593905 cites W3109420156 @default.
• W3216593905 cites W3126586474 @default.
• W3216593905 cites W3158398607 @default.
• W3216593905 doi "https://doi.org/10.1016/j.tranon.2021.101276" @default.
• W3216593905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8626684" @default.
• W3216593905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34823093" @default.
• W3216593905 hasPublicationYear "2022" @default.
• W3216593905 type Work @default.
• W3216593905 sameAs 3216593905 @default.
• W3216593905 citedByCount "11" @default.
• W3216593905 countsByYear W32165939052022 @default.
• W3216593905 countsByYear W32165939052023 @default.
• W3216593905 crossrefType "journal-article" @default.
• W3216593905 hasAuthorship W3216593905A5000631349 @default.
• W3216593905 hasAuthorship W3216593905A5003304508 @default.
• W3216593905 hasAuthorship W3216593905A5008894786 @default.
• W3216593905 hasAuthorship W3216593905A5012567937 @default.
• W3216593905 hasAuthorship W3216593905A5014453416 @default.
• W3216593905 hasAuthorship W3216593905A5017550861 @default.
• W3216593905 hasAuthorship W3216593905A5017669867 @default.
• W3216593905 hasAuthorship W3216593905A5017769557 @default.
• W3216593905 hasAuthorship W3216593905A5020080512 @default.
• W3216593905 hasAuthorship W3216593905A5022841989 @default.
• W3216593905 hasAuthorship W3216593905A5034618792 @default.
• W3216593905 hasAuthorship W3216593905A5035063101 @default.
• W3216593905 hasAuthorship W3216593905A5038974897 @default.
• W3216593905 hasAuthorship W3216593905A5039140100 @default.
• W3216593905 hasAuthorship W3216593905A5041934777 @default.
• W3216593905 hasAuthorship W3216593905A5042574444 @default.
• W3216593905 hasAuthorship W3216593905A5044612760 @default.
• W3216593905 hasAuthorship W3216593905A5044887899 @default.
• W3216593905 hasAuthorship W3216593905A5047294452 @default.
• W3216593905 hasAuthorship W3216593905A5048183782 @default.
• W3216593905 hasAuthorship W3216593905A5057297789 @default.
• W3216593905 hasAuthorship W3216593905A5058117531 @default.
• W3216593905 hasAuthorship W3216593905A5060388485 @default.
• W3216593905 hasAuthorship W3216593905A5065133327 @default.
• W3216593905 hasAuthorship W3216593905A5068440395 @default.
• W3216593905 hasAuthorship W3216593905A5070081985 @default.
• W3216593905 hasAuthorship W3216593905A5071235015 @default.
• W3216593905 hasAuthorship W3216593905A5072569354 @default.

• next