Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216630089> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W3216630089 abstract "Exposure to altered microbial characteristics as a consequence of moisture damage indoors is considered to be a key factor behind the observed health effects. Nevertheless, the connection between moisture damage, microbial exposure, adverse health effects and pathophysiological mechanisms is still unknown. Our aim was to study toxicology-related gene expression in airway epithelium after exposure to indoor particulate matter (PM) sampled from moisture-damaged houses. Normal human bronchial epithelial cells (NHBE) were differentiated in air-liquid interface for 22 days. The airway constructs were exposed (24 h) to three doses of indoor PM (1:16, 1:8, 1:4) sampled from nine moisture-damaged vs. non-moisture-damaged -house pairs, each pair having similar construction, age, and geographical location. The RNA of the airway constructs was extracted and sequenced for 386 genes associated with toxicological responses. In the pairwise comparison, 43 genes were differentially expressed upon exposure to indoor PM from damaged versus control homes; eight genes were differentially expressed more than five-fold. Both up- and down-regulation was demonstrated among the expressed genes. Most of the expressed genes were related to immunotoxicity; also genes related to steatosis, cholestasis, phospholipidosis and necrosis were affected. None of the genes was expressed systematically in all of the house pair -comparisons. The results indicate that the exposure to indoor PM from moisture-damaged houses activates especially immune defense-related genes in human airway constructs, but the effect does not manifest in the same way in every moisture-damaged house." @default.
- W3216630089 created "2021-12-06" @default.
- W3216630089 creator A5025969646 @default.
- W3216630089 creator A5031108056 @default.
- W3216630089 creator A5034181133 @default.
- W3216630089 creator A5035560083 @default.
- W3216630089 creator A5044749619 @default.
- W3216630089 date "2020-01-01" @default.
- W3216630089 modified "2023-10-09" @default.
- W3216630089 title "Activation of toxicology-related genes in human airway constructs after exposure to indoor air particulate matter from moisture-damaged houses" @default.
- W3216630089 hasPublicationYear "2020" @default.
- W3216630089 type Work @default.
- W3216630089 sameAs 3216630089 @default.
- W3216630089 citedByCount "0" @default.
- W3216630089 crossrefType "journal-article" @default.
- W3216630089 hasAuthorship W3216630089A5025969646 @default.
- W3216630089 hasAuthorship W3216630089A5031108056 @default.
- W3216630089 hasAuthorship W3216630089A5034181133 @default.
- W3216630089 hasAuthorship W3216630089A5035560083 @default.
- W3216630089 hasAuthorship W3216630089A5044749619 @default.
- W3216630089 hasConcept C104317684 @default.
- W3216630089 hasConcept C105702510 @default.
- W3216630089 hasConcept C176864760 @default.
- W3216630089 hasConcept C178790620 @default.
- W3216630089 hasConcept C185592680 @default.
- W3216630089 hasConcept C203014093 @default.
- W3216630089 hasConcept C2776954882 @default.
- W3216630089 hasConcept C2779777708 @default.
- W3216630089 hasConcept C33070731 @default.
- W3216630089 hasConcept C42407357 @default.
- W3216630089 hasConcept C54355233 @default.
- W3216630089 hasConcept C86803240 @default.
- W3216630089 hasConceptScore W3216630089C104317684 @default.
- W3216630089 hasConceptScore W3216630089C105702510 @default.
- W3216630089 hasConceptScore W3216630089C176864760 @default.
- W3216630089 hasConceptScore W3216630089C178790620 @default.
- W3216630089 hasConceptScore W3216630089C185592680 @default.
- W3216630089 hasConceptScore W3216630089C203014093 @default.
- W3216630089 hasConceptScore W3216630089C2776954882 @default.
- W3216630089 hasConceptScore W3216630089C2779777708 @default.
- W3216630089 hasConceptScore W3216630089C33070731 @default.
- W3216630089 hasConceptScore W3216630089C42407357 @default.
- W3216630089 hasConceptScore W3216630089C54355233 @default.
- W3216630089 hasConceptScore W3216630089C86803240 @default.
- W3216630089 hasLocation W32166300891 @default.
- W3216630089 hasOpenAccess W3216630089 @default.
- W3216630089 hasPrimaryLocation W32166300891 @default.
- W3216630089 isParatext "false" @default.
- W3216630089 isRetracted "false" @default.
- W3216630089 magId "3216630089" @default.
- W3216630089 workType "article" @default.