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- W3216652951 endingPage "12431" @default.
- W3216652951 startingPage "12431" @default.
- W3216652951 abstract "Adolescent neuropsychiatric disorders have been recently increasing due to genetic and environmental influences. Abnormal brain development before and after birth contribute to the pathology of neuropsychiatric disorders. However, it is difficult to experimentally investigate because of the complexity of brain and ethical constraints. Recently generated human brain organoids from pluripotent stem cells are considered as a promising in vitro model to recapitulate brain development and diseases. To better understand how brain organoids could be applied to investigate neuropsychiatric disorders, we analyzed the key consideration points, including how to generate brain organoids from pluripotent stem cells, the current application of brain organoids in recapitulating neuropsychiatric disorders and the future perspectives. This review covered what have been achieved on modeling the cellular and neural circuit deficits of neuropsychiatric disorders and those challenges yet to be solved. Together, this review aims to provide a fundamental understanding of how to generate brain organoids to model neuropsychiatric disorders, which will be helpful in improving the mental health of adolescents." @default.
- W3216652951 created "2021-12-06" @default.
- W3216652951 creator A5007388994 @default.
- W3216652951 creator A5030911529 @default.
- W3216652951 creator A5061084605 @default.
- W3216652951 date "2021-11-26" @default.
- W3216652951 modified "2023-09-25" @default.
- W3216652951 title "In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids" @default.
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- W3216652951 doi "https://doi.org/10.3390/ijerph182312431" @default.
- W3216652951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34886158" @default.
- W3216652951 hasPublicationYear "2021" @default.
- W3216652951 type Work @default.