Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216655770> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3216655770 abstract "Environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from industrial by-product is a dominant trigger of Non-alcoholic fatty liver disease (NAFLD) that induces an excess triglycerides buildup within the liver. This paper discusses whether knockout of upstream Aryl hydrocarbon receptor nuclear translocator (ARNT) relieves the liver burden in preventing abnormal lipid accumulation after TCDD exposure. This experiment utilizes two models (1) in vivo mice model and (2) in vitro human normal liver cell line model. The ARNT gene is knockout by CRISPR, and the expression of AhR-ARNT complex is detected. Intracellular copper transport assay, mitochondrial OCR analysis, liver function test and histology are then used to observe the ARNT-/- gene regulation and liver cell responses in both models. The most possible result is that ARNT knockout inhibits the TCDD-induced liver toxicity at the initial binding site without affecting the downstream gene regulation; both in vitro and in vivo models present a healthy liver state. The results will contribute crucial information on the TCDD-elicited gene regulation mechanism inside the liver cell, providing detailed environmental toxicant-triggered model studies relate to NAFLD. Prospective studies should focus on investigating the in detail potential side effects of ARNT knockout on the liver and other relative organs." @default.
- W3216655770 created "2021-12-06" @default.
- W3216655770 creator A5028764753 @default.
- W3216655770 date "2021-09-11" @default.
- W3216655770 modified "2023-09-23" @default.
- W3216655770 title "Effect of Inhibiting Upstream Aryl Hydrocarbon Receptor Nuclear Translocator on the TCDD-induced Non-alcoholic Fatty Liver Disease" @default.
- W3216655770 cites W2044715732 @default.
- W3216655770 cites W2138743300 @default.
- W3216655770 cites W2149572095 @default.
- W3216655770 cites W2770129291 @default.
- W3216655770 cites W3006028518 @default.
- W3216655770 doi "https://doi.org/10.1145/3487027.3487032" @default.
- W3216655770 hasPublicationYear "2021" @default.
- W3216655770 type Work @default.
- W3216655770 sameAs 3216655770 @default.
- W3216655770 citedByCount "0" @default.
- W3216655770 crossrefType "proceedings-article" @default.
- W3216655770 hasAuthorship W3216655770A5028764753 @default.
- W3216655770 hasConcept C104317684 @default.
- W3216655770 hasConcept C126322002 @default.
- W3216655770 hasConcept C134018914 @default.
- W3216655770 hasConcept C167400880 @default.
- W3216655770 hasConcept C170493617 @default.
- W3216655770 hasConcept C182704531 @default.
- W3216655770 hasConcept C185592680 @default.
- W3216655770 hasConcept C2777214474 @default.
- W3216655770 hasConcept C2777575235 @default.
- W3216655770 hasConcept C2778772119 @default.
- W3216655770 hasConcept C2779134260 @default.
- W3216655770 hasConcept C2780473477 @default.
- W3216655770 hasConcept C29730261 @default.
- W3216655770 hasConcept C2992672570 @default.
- W3216655770 hasConcept C33594762 @default.
- W3216655770 hasConcept C45815257 @default.
- W3216655770 hasConcept C502942594 @default.
- W3216655770 hasConcept C55493867 @default.
- W3216655770 hasConcept C63932345 @default.
- W3216655770 hasConcept C71924100 @default.
- W3216655770 hasConcept C86339819 @default.
- W3216655770 hasConcept C86803240 @default.
- W3216655770 hasConcept C95444343 @default.
- W3216655770 hasConceptScore W3216655770C104317684 @default.
- W3216655770 hasConceptScore W3216655770C126322002 @default.
- W3216655770 hasConceptScore W3216655770C134018914 @default.
- W3216655770 hasConceptScore W3216655770C167400880 @default.
- W3216655770 hasConceptScore W3216655770C170493617 @default.
- W3216655770 hasConceptScore W3216655770C182704531 @default.
- W3216655770 hasConceptScore W3216655770C185592680 @default.
- W3216655770 hasConceptScore W3216655770C2777214474 @default.
- W3216655770 hasConceptScore W3216655770C2777575235 @default.
- W3216655770 hasConceptScore W3216655770C2778772119 @default.
- W3216655770 hasConceptScore W3216655770C2779134260 @default.
- W3216655770 hasConceptScore W3216655770C2780473477 @default.
- W3216655770 hasConceptScore W3216655770C29730261 @default.
- W3216655770 hasConceptScore W3216655770C2992672570 @default.
- W3216655770 hasConceptScore W3216655770C33594762 @default.
- W3216655770 hasConceptScore W3216655770C45815257 @default.
- W3216655770 hasConceptScore W3216655770C502942594 @default.
- W3216655770 hasConceptScore W3216655770C55493867 @default.
- W3216655770 hasConceptScore W3216655770C63932345 @default.
- W3216655770 hasConceptScore W3216655770C71924100 @default.
- W3216655770 hasConceptScore W3216655770C86339819 @default.
- W3216655770 hasConceptScore W3216655770C86803240 @default.
- W3216655770 hasConceptScore W3216655770C95444343 @default.
- W3216655770 hasLocation W32166557701 @default.
- W3216655770 hasOpenAccess W3216655770 @default.
- W3216655770 hasPrimaryLocation W32166557701 @default.
- W3216655770 hasRelatedWork W2018368842 @default.
- W3216655770 hasRelatedWork W2033472167 @default.
- W3216655770 hasRelatedWork W2034583712 @default.
- W3216655770 hasRelatedWork W2038565043 @default.
- W3216655770 hasRelatedWork W2063619316 @default.
- W3216655770 hasRelatedWork W2074821979 @default.
- W3216655770 hasRelatedWork W2167874705 @default.
- W3216655770 hasRelatedWork W2169225653 @default.
- W3216655770 hasRelatedWork W2312865257 @default.
- W3216655770 hasRelatedWork W2414846389 @default.
- W3216655770 isParatext "false" @default.
- W3216655770 isRetracted "false" @default.
- W3216655770 magId "3216655770" @default.
- W3216655770 workType "article" @default.