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- W3216671124 abstract "In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and maintain DNA methylation in dividing and nondividing cells. Although these enzymes have an unremarkable DNA sequence specificity (CpG), their regional specificity is regulated by interactions with various protein factors, chromatin modifiers, and post-translational modifications of histones. Changes in the DNMT expression or interacting partners affect DNA methylation patterns. Consequently, the acquired gene expression may increase the proliferative potential of cells, often concomitant with loss of cell identity as found in cancer. Aberrant DNA methylation, including hypermethylation and hypomethylation at various genomic regions, therefore, is a hallmark of most cancers. Additionally, somatic mutations in DNMTs that affect catalytic activity were mapped in Acute Myeloid Leukemia cancer cells. Despite being very effective in some cancers, the clinically approved DNMT inhibitors lack specificity, which could result in a wide range of deleterious effects. Elucidating distinct molecular mechanisms of DNMTs will facilitate the discovery of alternative cancer therapeutic targets. This review is focused on: (i) the structure and characteristics of DNMTs, (ii) the prevalence of mutations and abnormal expression of DNMTs in cancer, (iii) factors that mediate their abnormal expression and (iv) the effect of anomalous DNMT-complexes in cancer." @default.
- W3216671124 created "2021-12-06" @default.
- W3216671124 creator A5020110134 @default.
- W3216671124 creator A5055455438 @default.
- W3216671124 creator A5059437074 @default.
- W3216671124 creator A5061457770 @default.
- W3216671124 creator A5064621815 @default.
- W3216671124 creator A5074511839 @default.
- W3216671124 creator A5079539367 @default.
- W3216671124 date "2021-10-04" @default.
- W3216671124 modified "2023-10-12" @default.
- W3216671124 title "Misregulation of the expression and activity of DNA methyltransferases in cancer" @default.
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