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- W3216681520 endingPage "170705" @default.
- W3216681520 startingPage "170705" @default.
- W3216681520 abstract "Corticotropin-releasing factor (CRF) is a 41-amino acid polypeptide that coordinates the endocrine system, autonomic nervous system, immune system, and physiological behavior. CRF is a signaling regulator in the neuro-endocrine-immune (NEI) network that mediates visceral hypersensitivity. Rodent models to simulate changes in intestinal motility similar to those reported in the irritable bowel syndrome (IBS), demonstrate that the CRF receptor 1 (CRF-R1) mediates intestinal hypersensitivity under many conditions. However, the translation of preclinical studies into clinical trials has not been successful possibly due to the lack of sufficient understanding of the multiple variants of CRF-R1 and CRF-R1 antagonists. Investigating the sites of action of central and peripheral CRF is critical for accelerating the translation from preclinical to clinical studies." @default.
- W3216681520 created "2021-12-06" @default.
- W3216681520 creator A5027514192 @default.
- W3216681520 creator A5034245602 @default.
- W3216681520 creator A5066268765 @default.
- W3216681520 creator A5067935862 @default.
- W3216681520 creator A5074609933 @default.
- W3216681520 date "2022-01-01" @default.
- W3216681520 modified "2023-10-07" @default.
- W3216681520 title "Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome" @default.
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