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- W3216725416 abstract "Abstract Selinexor developed by Karyopharm Therapeutics is the first orally available small-molecule inhibitor of exportin-1 (XPO1). XPO-1 is a protein transporter responsible for the export of macromolecules such as tumor suppressor proteins and oncoprotein mRNAs from the nucleus to the cytoplasm; its inhibition results in blocking of multiple oncogenic pathways. Overexpression of XPO1 is seen in multiple myeloma and various other malignancies and is a poor prognostic marker. Pivotal positive trials have resulted in the approval of selinexor for use in refractory or relapsed diffuse large B cell lymphoma and multiple myeloma. In this review, we briefly cover the drug development, mechanism of action, indications, and toxicities of the drug, and the major pivotal trials." @default.
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- W3216725416 date "2021-08-01" @default.
- W3216725416 modified "2023-09-23" @default.
- W3216725416 title "Selinexor—A Drug Review" @default.
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- W3216725416 doi "https://doi.org/10.1055/s-0041-1736680" @default.
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