FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216737900> ?p ?o ?g. }

• W3216737900 abstract "Objective: To detect genetic risk factors for cognitive decline in patients with Parkinson’s disease (PD) using a genotyping array specific for neurodegenerative diseases. Background: The relevance of genetic influences on the cognitive capacity in PD patients is not fully understood. Design/Methods: A comprehensive neuropsychological test battery was applied in an initial sample of 114 PD patients (77 M, 37 F; mean age: 66 years; mean education: 14 years) and their results were correlated with 1233 markers linked to neurodegenerative diseases from the NeuroChip Assay. For the cognitive decline over three years, the Reliable Change Index (RCI) was calculated. Tests with less than 10% missing values were 20-fold imputed using the MICE package. We used the PLINK tool box and performed linear regression. Quality control was performed by applying a minimum allele frequency of 5% and removing markers outside the Hardy-Weinberg equilibrium. We only report significant genetic markers with a False Discovery Rate (FDR) corrected p-value. Markers found in this first step were checked for the influence of confounding variables (age, time since diagnosis, education and medication) by linear regression. Results: Among all neuropsychological tests, only the change in visual construction capacity (Rey Figure copy) showed a significant p-value on all imputation folds with one of the tested markers (rs4548513, mean FDR corrected p-value Conclusions: SNP rs4548513 is known from literature as a suspected genetic risk factor for Alzheimer’s disease (AD). The present result supports the concept that cognitive decline in Alzheimers’s disease and PD share a underlying pathological mechanism. SNP rs4548513 is a candidate prognostic biomarker for visual cognitive deficits in PD and possibly also for PD dementia. Disclosure: Dr. Murezzan has nothing to disclose. Dr. Meyer has nothing to disclose. Dr. Gschwandtner has nothing to disclose. Dr. Liepelt has nothing to disclose. Dr. Brockmann has nothing to disclose. Dr. Schulte has nothing to disclose. Dr. Fuhr has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Roche. Dr. Roth has nothing to disclose." @default.
• W3216737900 created "2021-12-06" @default.
• W3216737900 creator A5004204996 @default.
• W3216737900 creator A5012739410 @default.
• W3216737900 creator A5019329971 @default.
• W3216737900 creator A5019362429 @default.
• W3216737900 creator A5023045793 @default.
• W3216737900 creator A5026330522 @default.
• W3216737900 creator A5052211172 @default.
• W3216737900 creator A5071378398 @default.
• W3216737900 date "2019-04-09" @default.
• W3216737900 modified "2023-09-26" @default.
• W3216737900 title "RS4548513 (CTNNA3): A Genetic Risk Factor for Visual Construction Deficiency in Parkinson’s disease (P1.1-016)" @default.
• W3216737900 hasPublicationYear "2019" @default.
• W3216737900 type Work @default.
• W3216737900 sameAs 3216737900 @default.
• W3216737900 citedByCount "0" @default.
• W3216737900 crossrefType "journal-article" @default.
• W3216737900 hasAuthorship W3216737900A5004204996 @default.
• W3216737900 hasAuthorship W3216737900A5012739410 @default.
• W3216737900 hasAuthorship W3216737900A5019329971 @default.
• W3216737900 hasAuthorship W3216737900A5019362429 @default.
• W3216737900 hasAuthorship W3216737900A5023045793 @default.
• W3216737900 hasAuthorship W3216737900A5026330522 @default.
• W3216737900 hasAuthorship W3216737900A5052211172 @default.
• W3216737900 hasAuthorship W3216737900A5071378398 @default.
• W3216737900 hasConcept C105795698 @default.
• W3216737900 hasConcept C118552586 @default.
• W3216737900 hasConcept C126322002 @default.
• W3216737900 hasConcept C14216870 @default.
• W3216737900 hasConcept C143998085 @default.
• W3216737900 hasConcept C15744967 @default.
• W3216737900 hasConcept C169900460 @default.
• W3216737900 hasConcept C2779134260 @default.
• W3216737900 hasConcept C2779483572 @default.
• W3216737900 hasConcept C2779734285 @default.
• W3216737900 hasConcept C2984863031 @default.
• W3216737900 hasConcept C33923547 @default.
• W3216737900 hasConcept C548259974 @default.
• W3216737900 hasConcept C58041806 @default.
• W3216737900 hasConcept C71924100 @default.
• W3216737900 hasConcept C77350462 @default.
• W3216737900 hasConcept C9357733 @default.
• W3216737900 hasConceptScore W3216737900C105795698 @default.
• W3216737900 hasConceptScore W3216737900C118552586 @default.
• W3216737900 hasConceptScore W3216737900C126322002 @default.
• W3216737900 hasConceptScore W3216737900C14216870 @default.
• W3216737900 hasConceptScore W3216737900C143998085 @default.
• W3216737900 hasConceptScore W3216737900C15744967 @default.
• W3216737900 hasConceptScore W3216737900C169900460 @default.
• W3216737900 hasConceptScore W3216737900C2779134260 @default.
• W3216737900 hasConceptScore W3216737900C2779483572 @default.
• W3216737900 hasConceptScore W3216737900C2779734285 @default.
• W3216737900 hasConceptScore W3216737900C2984863031 @default.
• W3216737900 hasConceptScore W3216737900C33923547 @default.
• W3216737900 hasConceptScore W3216737900C548259974 @default.
• W3216737900 hasConceptScore W3216737900C58041806 @default.
• W3216737900 hasConceptScore W3216737900C71924100 @default.
• W3216737900 hasConceptScore W3216737900C77350462 @default.
• W3216737900 hasConceptScore W3216737900C9357733 @default.
• W3216737900 hasLocation W32167379001 @default.
• W3216737900 hasOpenAccess W3216737900 @default.
• W3216737900 hasPrimaryLocation W32167379001 @default.
• W3216737900 hasVolume "92" @default.
• W3216737900 isParatext "false" @default.
• W3216737900 isRetracted "false" @default.
• W3216737900 magId "3216737900" @default.
• W3216737900 workType "article" @default.