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- W3216745145 abstract "Amplifications of oncogenic genes are often considered actionable. However, not all patients respond. Questions have therefore arisen regarding the degree to which amplifications, especially non-focal ones, mediate overexpression. We found that a subset of high-level gene amplifications (≥ 6 copies) (from The Cancer Genome Atlas database) was not over-expressed at the RNA level. Unexpectedly, focal amplifications were more frequently silenced than non-focal amplifications. Most non-focal amplifications were not silenced; therefore, non-focal amplifications, if over-expressed, may be therapeutically tractable. Furthermore, specific silencing of high-level focal or non-focal gene amplifications may explain resistance to drugs that target the relevant gene product." @default.
- W3216745145 created "2021-12-06" @default.
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- W3216745145 date "2021-12-01" @default.
- W3216745145 modified "2023-10-18" @default.
- W3216745145 title "Therapeutic implications of cancer gene amplifications without mRNA overexpression: silence may not be golden" @default.
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- W3216745145 doi "https://doi.org/10.1186/s13045-021-01211-1" @default.
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