Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216753611> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3216753611 endingPage "1994" @default.
- W3216753611 startingPage "1989" @default.
- W3216753611 abstract "The objective of this study was to deal with the evaluation of 7-(2-(benzylideneamino)-2-(cyclohexa-1,4-dienyl)acetamido)-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid based schiff bases as a new class of enzyme inhibitors. In this connection, a series of Schiff bases of cephradine with substituted aromatic aldehydes was synthesized and characterized using FTIR, 1HNMR and 13CNMR. The in-vitro biological activities including free radical scavenging potential using DPPH assay, acetyl cholinesterase and butyryl cholinesterase inhibition potential were evaluated. Two compounds of the series 1g and 1h were found to be active against AChE whereas no derivative was active against BChE while the whole series showed excellent 1, 1-diphenyl-2-picrylhydrazyl scavenging activity. All the synthesized compounds were found to be non-toxic and present passive gastrointestinal absorption. Furthermore, the study suggests that the synthesized cephradine derivatives exhibit inhibitory potential against different biologically relevant enzyme targets." @default.
- W3216753611 created "2021-12-06" @default.
- W3216753611 creator A5039751520 @default.
- W3216753611 creator A5046919924 @default.
- W3216753611 creator A5068474269 @default.
- W3216753611 creator A5075572653 @default.
- W3216753611 creator A5085112734 @default.
- W3216753611 creator A5087215280 @default.
- W3216753611 date "2021-09-01" @default.
- W3216753611 modified "2023-09-23" @default.
- W3216753611 title "Synthesis, characterization, SAR, antioxidant, anti-acetylcholinesterase and anti-butyrylcholinesterase activities of cephradine Schiff bases." @default.
- W3216753611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34836871" @default.
- W3216753611 hasPublicationYear "2021" @default.
- W3216753611 type Work @default.
- W3216753611 sameAs 3216753611 @default.
- W3216753611 citedByCount "0" @default.
- W3216753611 crossrefType "journal-article" @default.
- W3216753611 hasAuthorship W3216753611A5039751520 @default.
- W3216753611 hasAuthorship W3216753611A5046919924 @default.
- W3216753611 hasAuthorship W3216753611A5068474269 @default.
- W3216753611 hasAuthorship W3216753611A5075572653 @default.
- W3216753611 hasAuthorship W3216753611A5085112734 @default.
- W3216753611 hasAuthorship W3216753611A5087215280 @default.
- W3216753611 hasConcept C178790620 @default.
- W3216753611 hasConcept C181199279 @default.
- W3216753611 hasConcept C185592680 @default.
- W3216753611 hasConcept C21951064 @default.
- W3216753611 hasConcept C2776428424 @default.
- W3216753611 hasConcept C2778004101 @default.
- W3216753611 hasConcept C2778816929 @default.
- W3216753611 hasConcept C2779059548 @default.
- W3216753611 hasConcept C2779101902 @default.
- W3216753611 hasConcept C2781401929 @default.
- W3216753611 hasConcept C2910396414 @default.
- W3216753611 hasConcept C31896038 @default.
- W3216753611 hasConcept C501593827 @default.
- W3216753611 hasConcept C55493867 @default.
- W3216753611 hasConcept C64778159 @default.
- W3216753611 hasConcept C71240020 @default.
- W3216753611 hasConcept C71924100 @default.
- W3216753611 hasConcept C98274493 @default.
- W3216753611 hasConceptScore W3216753611C178790620 @default.
- W3216753611 hasConceptScore W3216753611C181199279 @default.
- W3216753611 hasConceptScore W3216753611C185592680 @default.
- W3216753611 hasConceptScore W3216753611C21951064 @default.
- W3216753611 hasConceptScore W3216753611C2776428424 @default.
- W3216753611 hasConceptScore W3216753611C2778004101 @default.
- W3216753611 hasConceptScore W3216753611C2778816929 @default.
- W3216753611 hasConceptScore W3216753611C2779059548 @default.
- W3216753611 hasConceptScore W3216753611C2779101902 @default.
- W3216753611 hasConceptScore W3216753611C2781401929 @default.
- W3216753611 hasConceptScore W3216753611C2910396414 @default.
- W3216753611 hasConceptScore W3216753611C31896038 @default.
- W3216753611 hasConceptScore W3216753611C501593827 @default.
- W3216753611 hasConceptScore W3216753611C55493867 @default.
- W3216753611 hasConceptScore W3216753611C64778159 @default.
- W3216753611 hasConceptScore W3216753611C71240020 @default.
- W3216753611 hasConceptScore W3216753611C71924100 @default.
- W3216753611 hasConceptScore W3216753611C98274493 @default.
- W3216753611 hasLocation W32167536111 @default.
- W3216753611 hasOpenAccess W3216753611 @default.
- W3216753611 hasPrimaryLocation W32167536111 @default.
- W3216753611 hasVolume "34" @default.
- W3216753611 isParatext "false" @default.
- W3216753611 isRetracted "false" @default.
- W3216753611 magId "3216753611" @default.
- W3216753611 workType "article" @default.