FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216773705> ?p ?o ?g. }

• W3216773705 endingPage "474" @default.
• W3216773705 startingPage "461" @default.
• W3216773705 abstract "Osteoarthritis (OA) pathogenesis involves the interaction of articular cartilage with surrounding tissues, which are innervated by tyrosine hydroxylase-positive (TH+) sympathetic nerve fibers suggesting a role of the sympathetic nervous system (SNS) during OA progression. We analyzed the effects of sympathectomy (Syx) in a murine OA model.Peripheral Syx was generated by 6-hydroxydopamine (6-OHDA) injections in male C57BL/6 mice. OA was induced in wild-type (WT) and Syx mice by destabilization of the medial meniscus (DMM). TH+ fibers and splenic NE were analyzed to evaluate Syx efficiency. OA progression was examined by OARSI and synovitis scores and micro-CT. Expression of TH, α2A- and β2-adrenergic receptors (AR), and activity of osteoblasts (ALP) and osteoclasts (TRAP) was investigated by stainings.Syx resulted in synovial TH+ fiber elimination and splenic NE decrease. Cartilage degradation and synovitis after DMM were comparably progressive in both WT and Syx mice. Calcified cartilage (CC) and subchondral bone plate (SCBP) thickness and bone volume fraction (BV/TV) increased in Syx mice due to increased ALP and decreased TRAP activities compared to WT 8 weeks after DMMWT and Syx mice developed osteophytes and meniscal ossicles without any differences between the groups. AR numbers decreased in cartilage but increased in synovium and osteophyte regions after DMM in both WT and Syx mice.Peripheral dampening of SNS activity aggravated OA-specific cartilage calcification and subchondral bone thickening but did not influence cartilage degradation and synovitis. Therefore, SNS might be an attractive target for the development of novel therapeutic strategies for pathologies of the subchondral bone." @default.
• W3216773705 created "2021-12-06" @default.
• W3216773705 creator A5003537474 @default.
• W3216773705 creator A5011592421 @default.
• W3216773705 creator A5023417557 @default.
• W3216773705 creator A5031210648 @default.
• W3216773705 creator A5038147514 @default.
• W3216773705 creator A5039184689 @default.
• W3216773705 creator A5056157272 @default.
• W3216773705 creator A5063917292 @default.
• W3216773705 creator A5066005094 @default.
• W3216773705 creator A5066819961 @default.
• W3216773705 creator A5081113826 @default.
• W3216773705 date "2022-03-01" @default.
• W3216773705 modified "2023-10-18" @default.
• W3216773705 title "Sympathectomy aggravates subchondral bone changes during osteoarthritis progression in mice without affecting cartilage degeneration or synovial inflammation" @default.
• W3216773705 cites W1497427077 @default.
• W3216773705 cites W1677242229 @default.
• W3216773705 cites W1963686806 @default.
• W3216773705 cites W1965665343 @default.
• W3216773705 cites W1977014779 @default.
• W3216773705 cites W1980361118 @default.
• W3216773705 cites W1982218488 @default.
• W3216773705 cites W1982835526 @default.
• W3216773705 cites W1991907993 @default.
• W3216773705 cites W1997508587 @default.
• W3216773705 cites W2002251686 @default.
• W3216773705 cites W2013255360 @default.
• W3216773705 cites W2013684315 @default.
• W3216773705 cites W2025079451 @default.
• W3216773705 cites W2040275552 @default.
• W3216773705 cites W2057382554 @default.
• W3216773705 cites W2066215643 @default.
• W3216773705 cites W2071718640 @default.
• W3216773705 cites W2075354833 @default.
• W3216773705 cites W2080879189 @default.
• W3216773705 cites W2085687131 @default.
• W3216773705 cites W2085892048 @default.
• W3216773705 cites W2118476803 @default.
• W3216773705 cites W2127174807 @default.
• W3216773705 cites W2128414222 @default.
• W3216773705 cites W2135946292 @default.
• W3216773705 cites W2139859050 @default.
• W3216773705 cites W2147510409 @default.
• W3216773705 cites W2151429049 @default.
• W3216773705 cites W2167795966 @default.
• W3216773705 cites W2172612369 @default.
• W3216773705 cites W2344741743 @default.
• W3216773705 cites W2399762348 @default.
• W3216773705 cites W2504736578 @default.
• W3216773705 cites W2602377726 @default.
• W3216773705 cites W2789684080 @default.
• W3216773705 cites W2886908391 @default.
• W3216773705 cites W2953442577 @default.
• W3216773705 cites W3000490881 @default.
• W3216773705 cites W3009706486 @default.
• W3216773705 cites W3013985286 @default.
• W3216773705 cites W3126425516 @default.
• W3216773705 cites W4210254819 @default.
• W3216773705 cites W4232024554 @default.
• W3216773705 doi "https://doi.org/10.1016/j.joca.2021.11.016" @default.
• W3216773705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34864169" @default.
• W3216773705 hasPublicationYear "2022" @default.
• W3216773705 type Work @default.
• W3216773705 sameAs 3216773705 @default.
• W3216773705 citedByCount "9" @default.
• W3216773705 countsByYear W32167737052022 @default.
• W3216773705 countsByYear W32167737052023 @default.
• W3216773705 crossrefType "journal-article" @default.
• W3216773705 hasAuthorship W3216773705A5003537474 @default.
• W3216773705 hasAuthorship W3216773705A5011592421 @default.
• W3216773705 hasAuthorship W3216773705A5023417557 @default.
• W3216773705 hasAuthorship W3216773705A5031210648 @default.
• W3216773705 hasAuthorship W3216773705A5038147514 @default.
• W3216773705 hasAuthorship W3216773705A5039184689 @default.
• W3216773705 hasAuthorship W3216773705A5056157272 @default.
• W3216773705 hasAuthorship W3216773705A5063917292 @default.
• W3216773705 hasAuthorship W3216773705A5066005094 @default.
• W3216773705 hasAuthorship W3216773705A5066819961 @default.
• W3216773705 hasAuthorship W3216773705A5081113826 @default.
• W3216773705 hasBestOaLocation W32167737051 @default.
• W3216773705 hasConcept C105702510 @default.
• W3216773705 hasConcept C126322002 @default.
• W3216773705 hasConcept C134018914 @default.
• W3216773705 hasConcept C142724271 @default.
• W3216773705 hasConcept C185592680 @default.
• W3216773705 hasConcept C204787440 @default.
• W3216773705 hasConcept C2776164576 @default.
• W3216773705 hasConcept C2777077863 @default.
• W3216773705 hasConcept C2779244835 @default.
• W3216773705 hasConcept C2780309369 @default.
• W3216773705 hasConcept C2780550940 @default.
• W3216773705 hasConcept C71924100 @default.
• W3216773705 hasConceptScore W3216773705C105702510 @default.
• W3216773705 hasConceptScore W3216773705C126322002 @default.
• W3216773705 hasConceptScore W3216773705C134018914 @default.
• W3216773705 hasConceptScore W3216773705C142724271 @default.
• W3216773705 hasConceptScore W3216773705C185592680 @default.

• next