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- W3216801812 abstract "Methotrexate (MTX), a synthetic antimetabolite with a wide range of therapeutic indications, although its liver toxicity induced mainly through oxidative stress limits its clinical use. Vitamin C (ascorbic acid) possesses potent antioxidant and anti-inflammatory properties, Therefore, has a possible hepatoprotective effect. This study seeks to address the hepatoprotective effects of vitamin C against MTX-induced liver injury in albino mice. MTX showed significant elevation in both serum Alanine aminotransferase (ALT) and liver tissue Malondialdehyde (MDA), indicating hepatic injury, while vitamin C pre-treatment will hold down this elevation significantly and dose-dependently, causing amelioration of the toxic effect of MTX; the histopathological findings also support this finding. Also, MTX causes consumption of liver tissue content of superoxide dismutase (SOD) and Glutathione (GSH), while vitamin C pre-treatment boosts the SOD hepatic tissue level while GSH is diminished even more. In conclusion, vitamin C has a dose-dependent amelioration effect on the toxic effect of MTX on the liver." @default.
- W3216801812 created "2021-12-06" @default.
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- W3216801812 date "2021-11-27" @default.
- W3216801812 modified "2023-10-16" @default.
- W3216801812 title "HEPATOPROTECTIVE EFFECTS OF VITAMIN C AGAINST METHOTREXATE INDUCED ACUTE LIVER INJURY: AN EXPERIMENTAL STUDY" @default.
- W3216801812 doi "https://doi.org/10.21608/bfsa.2021.93074.1164" @default.
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