FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216873600> ?p ?o ?g. }

• W3216873600 endingPage "220" @default.
• W3216873600 startingPage "212" @default.
• W3216873600 abstract "Objectives Metastatic renal cell carcinoma can occur synchronously or metachronously. We characterized the time from diagnosis to systematic therapy as a categorical variable to analyze its effect on the overall survival and first‐line treatment efficacy of metastatic renal cell carcinoma patients. Methods We initially enrolled 949 consecutive metastatic renal cell carcinoma patients treated with targeted therapies retrospectively from December 2005 to December 2019. X‐tile analysis was used to determine cut‐off values of time from diagnosis to systematic therapy referring to overall survival. Patients were divided into different groups based on the time from diagnosis to systematic therapy and then analyzed for survival. Results Of 358 eligible patients with metastatic renal cell carcinoma, 125 (34.9%) had synchronous metastases followed by cytoreductive nephrectomy, and 233 (65.1%) had metachronous metastases. A total of 28 patients received complete metastasectomy. Three optimal cut‐off values for the time from diagnosis to systematic therapy (months) – 1.1, 7.0 and 35.9 – were applied to divide the population into four groups: the synchro group (time from diagnosis to systematic therapy ≤1.0), early group (1.0 < time from diagnosis to systematic therapy ≤ 7.0), intermediate group (7.0 < time from diagnosis to systematic therapy < 36.0) and late group (time from diagnosis to systematic therapy ≥36.0). The targeted therapy‐related overall survival ( P < 0.001) and progression‐free survival ( P < 0.001) values were significantly different among the four groups. Patients with longer time from diagnosis to systematic therapy had better prognoses and promising efficacy of targeted therapy. With the prolongation of time from diagnosis to systematic therapy, complete metastasectomy was more likely to achieve and bring a better prognosis. Conclusions The time from diagnosis to systematic therapy impacts the survival of metastatic renal cell carcinoma patients treated with targeted therapy. The cutoff points of 1, 7 and 36 months were statistically significant. The statistical boundaries might be valuable in future model establishment." @default.
• W3216873600 created "2021-12-06" @default.
• W3216873600 creator A5014239012 @default.
• W3216873600 creator A5015028325 @default.
• W3216873600 creator A5016318026 @default.
• W3216873600 creator A5033139738 @default.
• W3216873600 creator A5036415386 @default.
• W3216873600 creator A5039883316 @default.
• W3216873600 creator A5042822692 @default.
• W3216873600 creator A5055174519 @default.
• W3216873600 creator A5057447454 @default.
• W3216873600 creator A5072109709 @default.
• W3216873600 creator A5078605887 @default.
• W3216873600 creator A5082231423 @default.
• W3216873600 creator A5086731606 @default.
• W3216873600 date "2021-11-30" @default.
• W3216873600 modified "2023-09-26" @default.
• W3216873600 title "Novel cut‐off values of time from diagnosis to systematic therapy predict the overall survival and the efficacy of targeted therapy in renal cell carcinoma: A long‐term, follow‐up, retrospective study" @default.
• W3216873600 cites W1230106424 @default.
• W3216873600 cites W2001978232 @default.
• W3216873600 cites W2007495351 @default.
• W3216873600 cites W2031063133 @default.
• W3216873600 cites W2031087535 @default.
• W3216873600 cites W2047871200 @default.
• W3216873600 cites W2072478300 @default.
• W3216873600 cites W2088581716 @default.
• W3216873600 cites W2099088585 @default.
• W3216873600 cites W2099752220 @default.
• W3216873600 cites W2105397268 @default.
• W3216873600 cites W2105677187 @default.
• W3216873600 cites W2130657899 @default.
• W3216873600 cites W2133650808 @default.
• W3216873600 cites W2143782771 @default.
• W3216873600 cites W2149456801 @default.
• W3216873600 cites W2159079112 @default.
• W3216873600 cites W2162424705 @default.
• W3216873600 cites W2284518822 @default.
• W3216873600 cites W2295151631 @default.
• W3216873600 cites W2403664424 @default.
• W3216873600 cites W2503594413 @default.
• W3216873600 cites W2792937256 @default.
• W3216873600 cites W2801468242 @default.
• W3216873600 cites W2805060661 @default.
• W3216873600 cites W2887356481 @default.
• W3216873600 cites W2892325025 @default.
• W3216873600 cites W2904657085 @default.
• W3216873600 cites W2967470352 @default.
• W3216873600 cites W3036350371 @default.
• W3216873600 cites W3083155301 @default.
• W3216873600 cites W3087058492 @default.
• W3216873600 doi "https://doi.org/10.1111/iju.14751" @default.
• W3216873600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34847622" @default.
• W3216873600 hasPublicationYear "2021" @default.
• W3216873600 type Work @default.
• W3216873600 sameAs 3216873600 @default.
• W3216873600 citedByCount "1" @default.
• W3216873600 countsByYear W32168736002022 @default.
• W3216873600 crossrefType "journal-article" @default.
• W3216873600 hasAuthorship W3216873600A5014239012 @default.
• W3216873600 hasAuthorship W3216873600A5015028325 @default.
• W3216873600 hasAuthorship W3216873600A5016318026 @default.
• W3216873600 hasAuthorship W3216873600A5033139738 @default.
• W3216873600 hasAuthorship W3216873600A5036415386 @default.
• W3216873600 hasAuthorship W3216873600A5039883316 @default.
• W3216873600 hasAuthorship W3216873600A5042822692 @default.
• W3216873600 hasAuthorship W3216873600A5055174519 @default.
• W3216873600 hasAuthorship W3216873600A5057447454 @default.
• W3216873600 hasAuthorship W3216873600A5072109709 @default.
• W3216873600 hasAuthorship W3216873600A5078605887 @default.
• W3216873600 hasAuthorship W3216873600A5082231423 @default.
• W3216873600 hasAuthorship W3216873600A5086731606 @default.
• W3216873600 hasBestOaLocation W32168736001 @default.
• W3216873600 hasConcept C121608353 @default.
• W3216873600 hasConcept C126322002 @default.
• W3216873600 hasConcept C141071460 @default.
• W3216873600 hasConcept C143998085 @default.
• W3216873600 hasConcept C167135981 @default.
• W3216873600 hasConcept C17744445 @default.
• W3216873600 hasConcept C189708586 @default.
• W3216873600 hasConcept C199539241 @default.
• W3216873600 hasConcept C2777472916 @default.
• W3216873600 hasConcept C2778601017 @default.
• W3216873600 hasConcept C2779013556 @default.
• W3216873600 hasConcept C2779473830 @default.
• W3216873600 hasConcept C2780091579 @default.
• W3216873600 hasConcept C2780227381 @default.
• W3216873600 hasConcept C2781230642 @default.
• W3216873600 hasConcept C2908647359 @default.
• W3216873600 hasConcept C509974204 @default.
• W3216873600 hasConcept C71924100 @default.
• W3216873600 hasConcept C99454951 @default.
• W3216873600 hasConceptScore W3216873600C121608353 @default.
• W3216873600 hasConceptScore W3216873600C126322002 @default.
• W3216873600 hasConceptScore W3216873600C141071460 @default.
• W3216873600 hasConceptScore W3216873600C143998085 @default.
• W3216873600 hasConceptScore W3216873600C167135981 @default.
• W3216873600 hasConceptScore W3216873600C17744445 @default.
• W3216873600 hasConceptScore W3216873600C189708586 @default.

• next