FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216884966> ?p ?o ?g. }

• W3216884966 endingPage "1714" @default.
• W3216884966 startingPage "1714" @default.
• W3216884966 abstract "Anemia is a common complication in chronic kidney disease (CKD) with increased morbidity and mortality. Recently published RCTs were conducted to compare the effect of the new medication roxadustat (ROX) with erythropoiesis-stimulating agent (ESA) in dialysis-dependent CKD (DD-CKD) patients. Our article aimed to meta-analyze published RCTs to investigate the efficacy and safety of ROX for anemia in DD-CKD patients and update the effect of the new studies on overall analysis with subsequent impact on management.Electronic databases (PubMed, EMBASE, Scopus, Web of Science, Cochrane Central, and Google Scholar) were searched systematically from inception to July 2021 by using this search term (Roxadustat OR ASP1517 OR FG4592 OR FG-4592) AND (kidney OR renal) AND (Anemia). We only included randomized control trials (RCTs) that reported the primary outcome of change in hemoglobin (Hb) level and iron utilization parameters, including ferritin, serum iron, TSAT, TIBC, transferrin, and hepcidin.Ten RCTs were finally included with 3031 patients in the ROX group and 2737 patients in the control group. ROX was associated with increase in Hb level (SMD: 0.2; 95% CI: 0.02, 0.39; P=0.03), TIBC (SMD: 0.79; 95% CI: 0.61, 0.98; P<0.00001), serum iron (SMD: 0.27; 95% CI: 0.18, 0.36; P<0.00001), transferrin (SMD: 0.98; 95% CI: 0.81, 1.15; P<0.00001) and decrease in hepcidin (SMD: -15.53; 95% CI: -28.07, -3.00; P<0.02) when compared with control group. There was no difference between ROX and the control group regarding ferritin level and TSAT. Sensitivity analysis by removing the most recent studies, Chen et al. or Hou et al. did not show significant difference in regard to change in Hb level. There was no difference between both groups regarding the serious side effects. However, ROX showed higher TEAEs when compared to the control group (RR: 1.03; 95% CI: 1.01, 1.05; P=0.002).Our updated meta-analysis concluded that ROX increased Hb level and improved iron utilization parameters in DD-CKD patients, but ROX was associated with higher TEAEs. Our results support the use of ROX for DD-CKD patients with anemia. However, higher-quality RCTs are still needed to confirm the results of our review." @default.
• W3216884966 created "2021-12-06" @default.
• W3216884966 creator A5007904679 @default.
• W3216884966 creator A5011918442 @default.
• W3216884966 creator A5035349031 @default.
• W3216884966 creator A5043907474 @default.
• W3216884966 creator A5067599407 @default.
• W3216884966 creator A5080709675 @default.
• W3216884966 creator A5086114260 @default.
• W3216884966 date "2021-12-01" @default.
• W3216884966 modified "2023-09-26" @default.
• W3216884966 title "The efficacy of Roxadustat for the treatment of anemia in dialysis dependent chronic kidney disease patients: an updated systematic review and meta-analysis of randomized clinical trials" @default.
• W3216884966 doi "https://doi.org/10.21037/atm-21-4357" @default.
• W3216884966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35071408" @default.
• W3216884966 hasPublicationYear "2021" @default.
• W3216884966 type Work @default.
• W3216884966 sameAs 3216884966 @default.
• W3216884966 citedByCount "3" @default.
• W3216884966 countsByYear W32168849662022 @default.
• W3216884966 countsByYear W32168849662023 @default.
• W3216884966 crossrefType "journal-article" @default.
• W3216884966 hasAuthorship W3216884966A5007904679 @default.
• W3216884966 hasAuthorship W3216884966A5011918442 @default.
• W3216884966 hasAuthorship W3216884966A5035349031 @default.
• W3216884966 hasAuthorship W3216884966A5043907474 @default.
• W3216884966 hasAuthorship W3216884966A5067599407 @default.
• W3216884966 hasAuthorship W3216884966A5080709675 @default.
• W3216884966 hasAuthorship W3216884966A5086114260 @default.
• W3216884966 hasBestOaLocation W32168849661 @default.
• W3216884966 hasConcept C126322002 @default.
• W3216884966 hasConcept C168563851 @default.
• W3216884966 hasConcept C2776478404 @default.
• W3216884966 hasConcept C2776768029 @default.
• W3216884966 hasConcept C2778248108 @default.
• W3216884966 hasConcept C2778319317 @default.
• W3216884966 hasConcept C2778653478 @default.
• W3216884966 hasConcept C2778917026 @default.
• W3216884966 hasConcept C2779978075 @default.
• W3216884966 hasConcept C71924100 @default.
• W3216884966 hasConcept C90924648 @default.
• W3216884966 hasConcept C95190672 @default.
• W3216884966 hasConceptScore W3216884966C126322002 @default.
• W3216884966 hasConceptScore W3216884966C168563851 @default.
• W3216884966 hasConceptScore W3216884966C2776478404 @default.
• W3216884966 hasConceptScore W3216884966C2776768029 @default.
• W3216884966 hasConceptScore W3216884966C2778248108 @default.
• W3216884966 hasConceptScore W3216884966C2778319317 @default.
• W3216884966 hasConceptScore W3216884966C2778653478 @default.
• W3216884966 hasConceptScore W3216884966C2778917026 @default.
• W3216884966 hasConceptScore W3216884966C2779978075 @default.
• W3216884966 hasConceptScore W3216884966C71924100 @default.
• W3216884966 hasConceptScore W3216884966C90924648 @default.
• W3216884966 hasConceptScore W3216884966C95190672 @default.
• W3216884966 hasIssue "23" @default.
• W3216884966 hasLocation W32168849661 @default.
• W3216884966 hasLocation W32168849662 @default.
• W3216884966 hasLocation W32168849663 @default.
• W3216884966 hasOpenAccess W3216884966 @default.
• W3216884966 hasPrimaryLocation W32168849661 @default.
• W3216884966 hasRelatedWork W2013071898 @default.
• W3216884966 hasRelatedWork W2095421717 @default.
• W3216884966 hasRelatedWork W2126166431 @default.
• W3216884966 hasRelatedWork W2441433836 @default.
• W3216884966 hasRelatedWork W2960153845 @default.
• W3216884966 hasRelatedWork W3033539516 @default.
• W3216884966 hasRelatedWork W3121294931 @default.
• W3216884966 hasRelatedWork W4320709700 @default.
• W3216884966 hasRelatedWork W4367315080 @default.
• W3216884966 hasRelatedWork W4376647680 @default.
• W3216884966 hasVolume "9" @default.
• W3216884966 isParatext "false" @default.
• W3216884966 isRetracted "false" @default.
• W3216884966 magId "3216884966" @default.
• W3216884966 workType "article" @default.