Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216897668> ?p ?o ?g. }
- W3216897668 endingPage "395" @default.
- W3216897668 startingPage "381" @default.
- W3216897668 abstract "Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescence-associated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade." @default.
- W3216897668 created "2021-12-06" @default.
- W3216897668 creator A5031804980 @default.
- W3216897668 creator A5034405911 @default.
- W3216897668 creator A5040723869 @default.
- W3216897668 creator A5085958710 @default.
- W3216897668 date "2021-11-26" @default.
- W3216897668 modified "2023-09-27" @default.
- W3216897668 title "The innate immune system in human kidney inflammaging" @default.
- W3216897668 cites W1718420886 @default.
- W3216897668 cites W1808728066 @default.
- W3216897668 cites W1966094763 @default.
- W3216897668 cites W1972084827 @default.
- W3216897668 cites W1978523131 @default.
- W3216897668 cites W1999456570 @default.
- W3216897668 cites W2008353059 @default.
- W3216897668 cites W2012804478 @default.
- W3216897668 cites W2023122823 @default.
- W3216897668 cites W2025861570 @default.
- W3216897668 cites W2035188420 @default.
- W3216897668 cites W2035327965 @default.
- W3216897668 cites W2037466124 @default.
- W3216897668 cites W2051270619 @default.
- W3216897668 cites W2054975287 @default.
- W3216897668 cites W2063936236 @default.
- W3216897668 cites W2068172476 @default.
- W3216897668 cites W2071048562 @default.
- W3216897668 cites W2073572679 @default.
- W3216897668 cites W2074963908 @default.
- W3216897668 cites W2082402714 @default.
- W3216897668 cites W2094506819 @default.
- W3216897668 cites W2102018819 @default.
- W3216897668 cites W2122173685 @default.
- W3216897668 cites W2125521961 @default.
- W3216897668 cites W2127883421 @default.
- W3216897668 cites W2140748044 @default.
- W3216897668 cites W2143067351 @default.
- W3216897668 cites W2147100699 @default.
- W3216897668 cites W2152646993 @default.
- W3216897668 cites W2157511747 @default.
- W3216897668 cites W2158797289 @default.
- W3216897668 cites W2290128502 @default.
- W3216897668 cites W2309368936 @default.
- W3216897668 cites W2327446233 @default.
- W3216897668 cites W2394631798 @default.
- W3216897668 cites W2400908316 @default.
- W3216897668 cites W2411291192 @default.
- W3216897668 cites W2460676119 @default.
- W3216897668 cites W2475359437 @default.
- W3216897668 cites W2511456449 @default.
- W3216897668 cites W2570320605 @default.
- W3216897668 cites W2584418841 @default.
- W3216897668 cites W2588921827 @default.
- W3216897668 cites W2603208604 @default.
- W3216897668 cites W2613467981 @default.
- W3216897668 cites W2617431524 @default.
- W3216897668 cites W2727479556 @default.
- W3216897668 cites W2739698179 @default.
- W3216897668 cites W2743806965 @default.
- W3216897668 cites W2751838317 @default.
- W3216897668 cites W2755606742 @default.
- W3216897668 cites W2760424869 @default.
- W3216897668 cites W2761815519 @default.
- W3216897668 cites W2765275933 @default.
- W3216897668 cites W2765857895 @default.
- W3216897668 cites W2767465151 @default.
- W3216897668 cites W2768326320 @default.
- W3216897668 cites W2768825363 @default.
- W3216897668 cites W2792818721 @default.
- W3216897668 cites W2793358660 @default.
- W3216897668 cites W2803512641 @default.
- W3216897668 cites W2805557676 @default.
- W3216897668 cites W2809179845 @default.
- W3216897668 cites W2809611010 @default.
- W3216897668 cites W2884081989 @default.
- W3216897668 cites W2892274287 @default.
- W3216897668 cites W2893717696 @default.
- W3216897668 cites W2900031363 @default.
- W3216897668 cites W2900765807 @default.
- W3216897668 cites W2904283237 @default.
- W3216897668 cites W2916288123 @default.
- W3216897668 cites W2918652202 @default.
- W3216897668 cites W2918981672 @default.
- W3216897668 cites W2924274075 @default.
- W3216897668 cites W2943293743 @default.
- W3216897668 cites W2944041717 @default.
- W3216897668 cites W2948777985 @default.
- W3216897668 cites W2951084764 @default.
- W3216897668 cites W2952061841 @default.
- W3216897668 cites W2961582817 @default.
- W3216897668 cites W2963079825 @default.
- W3216897668 cites W2967015895 @default.
- W3216897668 cites W2975589949 @default.
- W3216897668 cites W2984434503 @default.
- W3216897668 cites W2986371880 @default.
- W3216897668 cites W2990926204 @default.
- W3216897668 cites W2996351571 @default.
- W3216897668 cites W2999096415 @default.