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- W3216908013 abstract "Abstract Introduction: Transcranial Direct Current Stimulation (TDCS) can modulate intrinsic cortical activity by stimulating specific brain areas. TDCS produces peripheral somatosensory co-stimulation that may contribute to the neuro-modulatory effects and hamper effective blinding. Objective: To assess how topical administration of numbing cream modifies the subjective tingling experience during sham relative to real TDCS in focal vs. non-focal and high- versus low-intensity stimulation settings. Methods: 30 healthy participants received bi-hemispheric TDCS targeting the hand representation of the left primary motor cortex (M1-HAND). We compared non-focal TDCS with a bi-polar montage (7x5cm electrodes) and focal TDCS with a center-surround montage (3cm diameter central electrodes, surrounded by 10cm diameter ring electrodes). TDCS was applied with randomized blocks of 2mA or 4mA (30sec ramp-up, 3min stimulation, 30sec ramp-down) and matched sham conditions (30sec ramp-up and down). Participants were tested across two days, with and without anesthetic cream applied underneath the electrodes. They rated their sensations of tingling following each stimulation block, with a 10-level VAS-score. We tested the effect of the experimental factors “numbing cream”, “focality of stimulation”, “intensity of stimulation”, and “sham-real stimulation” on VAS scores using repeated-measures ANOVA and non-parametric permutation tests (p<0.05). Results: Tingling was more intense during real TDCS relative to sham TDCS in the high-intensity but not low-intensity condition (sham-real x intensity interaction, p = 0.011). Topic application of numbing cream generally reduced VAS-ratings, but it did not alter the relative difference in tingling experience between real and sham TDCS, high-intensity and low-intensity TDCS, focal and non-focal stimulation. Conclusion: While inducing an overall attenuation of tingling experience, the use of numbing cream does not improve the matching of tingling experience between corresponding sham and real TDCS conditions. Keywords: peripheral effects, numbing cream, sham tDCS, focal high intensity" @default.
- W3216908013 created "2021-12-06" @default.
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- W3216908013 date "2021-11-01" @default.
- W3216908013 modified "2023-09-25" @default.
- W3216908013 title "Can topical application of numbing cream improve the efficacy of sham TDCS?" @default.
- W3216908013 doi "https://doi.org/10.1016/j.brs.2021.10.255" @default.
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