Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216935308> ?p ?o ?g. }
- W3216935308 abstract "Abstract Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes with known metabolite damage repair or preemption functions were identified and experimentally validated, including 5-formyltetrahydrofolate cyclo-ligase, CoA disulfide reductase, and certain hydrolases. Furthermore, we discovered that an enigmatic YqeK hydrolase domain fused to NadD has a novel proofreading function in NAD synthesis and could double as a MutT-like sanitizing enzyme for the nucleotide pool. Finally, we combined metabolomics and cheminformatics approaches to extend the core metabolic map of JCVI-Syn3A to include promiscuous enzymatic reactions and spontaneous side reactions. This extension revealed that several key metabolite damage-control systems remain to be identified in JCVI-Syn3A, such as that for methylglyoxal." @default.
- W3216935308 created "2021-12-06" @default.
- W3216935308 creator A5003957553 @default.
- W3216935308 creator A5004867963 @default.
- W3216935308 creator A5005516359 @default.
- W3216935308 creator A5009916442 @default.
- W3216935308 creator A5013938980 @default.
- W3216935308 creator A5017949757 @default.
- W3216935308 creator A5021740668 @default.
- W3216935308 creator A5026622925 @default.
- W3216935308 creator A5034363587 @default.
- W3216935308 creator A5039869133 @default.
- W3216935308 creator A5041973369 @default.
- W3216935308 creator A5043335302 @default.
- W3216935308 creator A5049842441 @default.
- W3216935308 creator A5067110170 @default.
- W3216935308 creator A5070268234 @default.
- W3216935308 creator A5070795814 @default.
- W3216935308 creator A5074636087 @default.
- W3216935308 creator A5079399175 @default.
- W3216935308 creator A5080995395 @default.
- W3216935308 creator A5084399793 @default.
- W3216935308 creator A5087349635 @default.
- W3216935308 creator A5089814391 @default.
- W3216935308 date "2021-12-01" @default.
- W3216935308 modified "2023-10-16" @default.
- W3216935308 title "Metabolite Damage and Damage-Control in a Minimal Genome" @default.
- W3216935308 cites W1480407041 @default.
- W3216935308 cites W1484037209 @default.
- W3216935308 cites W1487088539 @default.
- W3216935308 cites W1492975997 @default.
- W3216935308 cites W1497790249 @default.
- W3216935308 cites W1563812432 @default.
- W3216935308 cites W1605340054 @default.
- W3216935308 cites W1934481644 @default.
- W3216935308 cites W1967076877 @default.
- W3216935308 cites W1983748245 @default.
- W3216935308 cites W1985734471 @default.
- W3216935308 cites W1986459391 @default.
- W3216935308 cites W1989191870 @default.
- W3216935308 cites W1992968153 @default.
- W3216935308 cites W2002611021 @default.
- W3216935308 cites W2004965820 @default.
- W3216935308 cites W2014185980 @default.
- W3216935308 cites W2014361215 @default.
- W3216935308 cites W2024154477 @default.
- W3216935308 cites W2030555543 @default.
- W3216935308 cites W2034767282 @default.
- W3216935308 cites W2036083342 @default.
- W3216935308 cites W2037913221 @default.
- W3216935308 cites W2051554319 @default.
- W3216935308 cites W2058317852 @default.
- W3216935308 cites W2076165765 @default.
- W3216935308 cites W2084033585 @default.
- W3216935308 cites W2091899144 @default.
- W3216935308 cites W2104619491 @default.
- W3216935308 cites W2107409961 @default.
- W3216935308 cites W2129443011 @default.
- W3216935308 cites W2134370272 @default.
- W3216935308 cites W2134468107 @default.
- W3216935308 cites W2136306383 @default.
- W3216935308 cites W2142428670 @default.
- W3216935308 cites W2152207030 @default.
- W3216935308 cites W2158714788 @default.
- W3216935308 cites W2178778111 @default.
- W3216935308 cites W2295735828 @default.
- W3216935308 cites W2304674135 @default.
- W3216935308 cites W2329468465 @default.
- W3216935308 cites W2417067572 @default.
- W3216935308 cites W2471994457 @default.
- W3216935308 cites W2499440186 @default.
- W3216935308 cites W2501611887 @default.
- W3216935308 cites W2593151145 @default.
- W3216935308 cites W2622267958 @default.
- W3216935308 cites W2761114128 @default.
- W3216935308 cites W2762782847 @default.
- W3216935308 cites W2770709523 @default.
- W3216935308 cites W2772047293 @default.
- W3216935308 cites W2811178937 @default.
- W3216935308 cites W2894453071 @default.
- W3216935308 cites W2910514964 @default.
- W3216935308 cites W2952204176 @default.
- W3216935308 cites W2957309664 @default.
- W3216935308 cites W2987701831 @default.
- W3216935308 cites W4231551535 @default.
- W3216935308 cites W4243601081 @default.
- W3216935308 cites W4247896860 @default.
- W3216935308 cites W4294216483 @default.
- W3216935308 doi "https://doi.org/10.1101/2021.12.01.470718" @default.
- W3216935308 hasPublicationYear "2021" @default.
- W3216935308 type Work @default.
- W3216935308 sameAs 3216935308 @default.
- W3216935308 citedByCount "0" @default.
- W3216935308 crossrefType "posted-content" @default.
- W3216935308 hasAuthorship W3216935308A5003957553 @default.
- W3216935308 hasAuthorship W3216935308A5004867963 @default.
- W3216935308 hasAuthorship W3216935308A5005516359 @default.
- W3216935308 hasAuthorship W3216935308A5009916442 @default.
- W3216935308 hasAuthorship W3216935308A5013938980 @default.
- W3216935308 hasAuthorship W3216935308A5017949757 @default.