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• W3216948894 endingPage "1253" @default.
• W3216948894 startingPage "1253" @default.
• W3216948894 abstract "Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficiently deal with HAdV infections. Thus, there is a need to thoroughly understand HAdV-induced disease, and for the development and preclinical evaluation of HAdV therapeutics and/or vaccines, and consequently for suitable standardizable in vitro systems and animal models. Current animal models to study HAdV pathogenesis, persistence, and tumorigenesis include rodents such as Syrian hamsters, mice, and cotton rats, as well as rabbits. In addition, a few recent studies on other species, such as pigs and tree shrews, reported promising data. These models mimic (aspects of) HAdV-induced pathological changes in humans and, although they are relevant, an ideal HAdV animal model has yet to be developed. This review summarizes the available animal models of HAdV infection with comprehensive descriptions of virus-induced pathogenesis in different animal species. We also elaborate on rodent HAdV animal models and how they contributed to insights into adenovirus-induced cell transformation and cancer." @default.
• W3216948894 created "2021-12-06" @default.
• W3216948894 creator A5015592133 @default.
• W3216948894 creator A5024162582 @default.
• W3216948894 creator A5059530844 @default.
• W3216948894 date "2021-12-01" @default.
• W3216948894 modified "2023-10-02" @default.
• W3216948894 title "Animal Models in Human Adenovirus Research" @default.
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