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- W3216963570 endingPage "204062232110559" @default.
- W3216963570 startingPage "204062232110559" @default.
- W3216963570 abstract "Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the presence of painful nodules, abscesses, chronically draining fistulas, and scarring in apocrine gland-bearing areas of the body. The exact pathogenesis of HS is not yet well understood, but there is a consensus in considering HS a multifactorial disease with a genetic predisposition, an inflammatory dysregulation, and an influence of environmental modifying factors. Therapeutic approach of HS is challenging due to the wide clinical manifestations of the disease and the complex pathogenesis. This review describes evidence for effectiveness of current and emerging HS therapies. Topical therapy, systemic treatments, biological agents, surgery, and light therapy have been used for HS with variable results. Adalimumab is the only US Food and Drug Administration (FDA) approved biologic agent for moderate-to-severe HS, but new therapeutic options are being studied, targeting different specific cytokines involved in HS pathogenesis. Comparing treatment outcomes between therapies is difficult due to the lack of randomized controlled trials. Treatment strategy should be selected in concordance to disease severity and requires combination of treatments in most cases." @default.
- W3216963570 created "2021-12-06" @default.
- W3216963570 creator A5027590834 @default.
- W3216963570 creator A5037781626 @default.
- W3216963570 creator A5067344514 @default.
- W3216963570 creator A5073081453 @default.
- W3216963570 date "2021-01-01" @default.
- W3216963570 modified "2023-10-18" @default.
- W3216963570 title "New perspectives on the treatment of hidradenitis suppurativa" @default.
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