Matches in SemOpenAlex for { <https://semopenalex.org/work/W3216987297> ?p ?o ?g. }
- W3216987297 endingPage "191" @default.
- W3216987297 startingPage "179" @default.
- W3216987297 abstract "Ammonia is one of the major environmental pollutants in the pig industry that seriously affects the airway health of pigs. In this study, we aimed to investigate the metabolic profiling changes of piglets' lung tissue after the exposure of 0 ppm (CG), 20 ppm (LG) and 50 ppm (HG) ammonia for 30 days. Compared with the control group, the obvious lung lesions were observed in HG, including interstitial thickening, inflammatory cell infiltration and focal hemorrhage. The significantly increased content of malondialdehyde in HG, combined with the significantly decreased mRNA expression of antioxidase and inflammatory-regulators in exposure groups, implied that ammonia exposure induced oxidative stress and diminished the anti-inflammatory response in lung tissues. Metabolomic analyses of lung tissues revealed 15 significantly altered metabolites among the three groups including multiple amino acids, carbohydrates and lipids. The accumulation of succinic acid, linoleic acid and phosphorylethanolamine and consumption of glucose, quinolinic acid and aspartic acid in ammonia exposure groups, indicated that energy supply from glucose aerobic oxidation was suppressed and the glycolysis and lipolysis were activated in lung tissues induced by chronic ammonia exposure." @default.
- W3216987297 created "2021-12-06" @default.
- W3216987297 creator A5013801750 @default.
- W3216987297 creator A5025544446 @default.
- W3216987297 creator A5049396596 @default.
- W3216987297 creator A5068265932 @default.
- W3216987297 creator A5075602014 @default.
- W3216987297 creator A5078768332 @default.
- W3216987297 creator A5089620745 @default.
- W3216987297 date "2021-11-22" @default.
- W3216987297 modified "2023-10-13" @default.
- W3216987297 title "Chronic exposure to ammonia induces oxidative stress and enhanced glycolysis in lung of piglets" @default.
- W3216987297 cites W1176648364 @default.
- W3216987297 cites W1598151055 @default.
- W3216987297 cites W1839669064 @default.
- W3216987297 cites W1976327004 @default.
- W3216987297 cites W1992483596 @default.
- W3216987297 cites W2005904261 @default.
- W3216987297 cites W2011694441 @default.
- W3216987297 cites W2054913372 @default.
- W3216987297 cites W2063500986 @default.
- W3216987297 cites W2071575900 @default.
- W3216987297 cites W2089181989 @default.
- W3216987297 cites W2089532303 @default.
- W3216987297 cites W2107277218 @default.
- W3216987297 cites W2109429880 @default.
- W3216987297 cites W2116687544 @default.
- W3216987297 cites W2120134567 @default.
- W3216987297 cites W2145530136 @default.
- W3216987297 cites W2148362431 @default.
- W3216987297 cites W2162091548 @default.
- W3216987297 cites W2252404621 @default.
- W3216987297 cites W2289992612 @default.
- W3216987297 cites W2575108206 @default.
- W3216987297 cites W2587272171 @default.
- W3216987297 cites W2590207527 @default.
- W3216987297 cites W2590362410 @default.
- W3216987297 cites W2752539655 @default.
- W3216987297 cites W2755440026 @default.
- W3216987297 cites W2761160116 @default.
- W3216987297 cites W2789638177 @default.
- W3216987297 cites W2790462800 @default.
- W3216987297 cites W2804564324 @default.
- W3216987297 cites W2807678873 @default.
- W3216987297 cites W2890102060 @default.
- W3216987297 cites W2897035981 @default.
- W3216987297 cites W2899009117 @default.
- W3216987297 cites W2901765784 @default.
- W3216987297 cites W2906111942 @default.
- W3216987297 cites W2913533568 @default.
- W3216987297 cites W2914212804 @default.
- W3216987297 cites W2923046924 @default.
- W3216987297 cites W2944957677 @default.
- W3216987297 cites W2947274494 @default.
- W3216987297 cites W2964098746 @default.
- W3216987297 cites W2971758261 @default.
- W3216987297 cites W2979143021 @default.
- W3216987297 cites W2990363633 @default.
- W3216987297 cites W3018901764 @default.
- W3216987297 cites W3023923910 @default.
- W3216987297 cites W3043852432 @default.
- W3216987297 cites W3091162156 @default.
- W3216987297 doi "https://doi.org/10.1002/tox.23382" @default.
- W3216987297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34806272" @default.
- W3216987297 hasPublicationYear "2021" @default.
- W3216987297 type Work @default.
- W3216987297 sameAs 3216987297 @default.
- W3216987297 citedByCount "6" @default.
- W3216987297 countsByYear W32169872972022 @default.
- W3216987297 countsByYear W32169872972023 @default.
- W3216987297 crossrefType "journal-article" @default.
- W3216987297 hasAuthorship W3216987297A5013801750 @default.
- W3216987297 hasAuthorship W3216987297A5025544446 @default.
- W3216987297 hasAuthorship W3216987297A5049396596 @default.
- W3216987297 hasAuthorship W3216987297A5068265932 @default.
- W3216987297 hasAuthorship W3216987297A5075602014 @default.
- W3216987297 hasAuthorship W3216987297A5078768332 @default.
- W3216987297 hasAuthorship W3216987297A5089620745 @default.
- W3216987297 hasConcept C126322002 @default.
- W3216987297 hasConcept C185592680 @default.
- W3216987297 hasConcept C20251656 @default.
- W3216987297 hasConcept C2776151105 @default.
- W3216987297 hasConcept C2776382133 @default.
- W3216987297 hasConcept C2777714996 @default.
- W3216987297 hasConcept C2778401633 @default.
- W3216987297 hasConcept C31903555 @default.
- W3216987297 hasConcept C55493867 @default.
- W3216987297 hasConcept C62231903 @default.
- W3216987297 hasConcept C71924100 @default.
- W3216987297 hasConceptScore W3216987297C126322002 @default.
- W3216987297 hasConceptScore W3216987297C185592680 @default.
- W3216987297 hasConceptScore W3216987297C20251656 @default.
- W3216987297 hasConceptScore W3216987297C2776151105 @default.
- W3216987297 hasConceptScore W3216987297C2776382133 @default.
- W3216987297 hasConceptScore W3216987297C2777714996 @default.
- W3216987297 hasConceptScore W3216987297C2778401633 @default.
- W3216987297 hasConceptScore W3216987297C31903555 @default.
- W3216987297 hasConceptScore W3216987297C55493867 @default.