FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3217006454> ?p ?o ?g. }

• W3217006454 endingPage "151946" @default.
• W3217006454 startingPage "151946" @default.
• W3217006454 abstract "Inhibition of ruminal bacterial urease activity could slow down the decomposition of urea to ammonia, which would lead to a decrease in urea synthesis in the liver and urea-N emission in the urine. In order to find a rumen bacterial urease specific inhibitor that is environmentally friendly, we used the homology model of rumen bacterial urease as the target to screen natural compounds from plants by molecular docking. The screening results showed that coptisine had the most potential to inhibit the activity of rumen bacterial urease with an IC50 of 2.45 μM, which was superior to the traditional inhibitor acetohydroxamic acid. The enzyme kinetics results indicated coptisine was mixed type inhibitor of rumen bacterial urease with a Ki value of 0.68 μM. Coptisine significantly decreased the release of NH3 and decomposition of urea and improved microbial fermentation in a rumen fermentation system in vitro. Thiol-containing compounds or boric acid significantly decreased the inhibitory capacity of coptisine toward rumen bacterial urease, which indicated that coptisine could interact with both the urease active center Ni and amino acid residues possessing sulfhydryl groups in the flap area. The molecular docking results showed that coptisine acted as the metal acceptor for one nickel ion in the active site, and formed hydrogen bonds with the amino acid residues His320 and His362, which were located in the active site and flap region, respectively. These findings emphasized the potential role of coptisine in reducing nitrogen emissions that originate from ruminants by regulating rumen bacterial urease activity." @default.
• W3217006454 created "2021-12-06" @default.
• W3217006454 creator A5021384155 @default.
• W3217006454 creator A5029762841 @default.
• W3217006454 creator A5034294892 @default.
• W3217006454 creator A5065660628 @default.
• W3217006454 creator A5075662602 @default.
• W3217006454 creator A5084736096 @default.
• W3217006454 date "2022-02-01" @default.
• W3217006454 modified "2023-10-18" @default.
• W3217006454 title "Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking" @default.
• W3217006454 cites W1980272927 @default.
• W3217006454 cites W2015304573 @default.
• W3217006454 cites W2021006666 @default.
• W3217006454 cites W2038689960 @default.
• W3217006454 cites W2083784462 @default.
• W3217006454 cites W2098118571 @default.
• W3217006454 cites W2108317022 @default.
• W3217006454 cites W2149525061 @default.
• W3217006454 cites W2151296520 @default.
• W3217006454 cites W2155047938 @default.
• W3217006454 cites W2158123709 @default.
• W3217006454 cites W2158835468 @default.
• W3217006454 cites W2185823919 @default.
• W3217006454 cites W2219016437 @default.
• W3217006454 cites W2266935529 @default.
• W3217006454 cites W2274505135 @default.
• W3217006454 cites W2290738321 @default.
• W3217006454 cites W2411067909 @default.
• W3217006454 cites W2570108627 @default.
• W3217006454 cites W2583758130 @default.
• W3217006454 cites W2587635413 @default.
• W3217006454 cites W2610902397 @default.
• W3217006454 cites W2786671949 @default.
• W3217006454 cites W2788923218 @default.
• W3217006454 cites W2792776112 @default.
• W3217006454 cites W2804822363 @default.
• W3217006454 cites W2890134799 @default.
• W3217006454 cites W2899374518 @default.
• W3217006454 cites W2907904604 @default.
• W3217006454 cites W2912171584 @default.
• W3217006454 cites W2914840694 @default.
• W3217006454 cites W2935714032 @default.
• W3217006454 cites W2935820305 @default.
• W3217006454 cites W2940005676 @default.
• W3217006454 cites W2953466114 @default.
• W3217006454 cites W2980711877 @default.
• W3217006454 cites W3008647453 @default.
• W3217006454 cites W3028254476 @default.
• W3217006454 cites W3040203678 @default.
• W3217006454 cites W3046828752 @default.
• W3217006454 cites W3054845847 @default.
• W3217006454 cites W3069761598 @default.
• W3217006454 cites W3120143038 @default.
• W3217006454 doi "https://doi.org/10.1016/j.scitotenv.2021.151946" @default.
• W3217006454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34843773" @default.
• W3217006454 hasPublicationYear "2022" @default.
• W3217006454 type Work @default.
• W3217006454 sameAs 3217006454 @default.
• W3217006454 citedByCount "4" @default.
• W3217006454 countsByYear W32170064542022 @default.
• W3217006454 countsByYear W32170064542023 @default.
• W3217006454 crossrefType "journal-article" @default.
• W3217006454 hasAuthorship W3217006454A5021384155 @default.
• W3217006454 hasAuthorship W3217006454A5029762841 @default.
• W3217006454 hasAuthorship W3217006454A5034294892 @default.
• W3217006454 hasAuthorship W3217006454A5065660628 @default.
• W3217006454 hasAuthorship W3217006454A5075662602 @default.
• W3217006454 hasAuthorship W3217006454A5084736096 @default.
• W3217006454 hasConcept C100544194 @default.
• W3217006454 hasConcept C159110408 @default.
• W3217006454 hasConcept C185592680 @default.
• W3217006454 hasConcept C2776661111 @default.
• W3217006454 hasConcept C2778439678 @default.
• W3217006454 hasConcept C2779521917 @default.
• W3217006454 hasConcept C2780116568 @default.
• W3217006454 hasConcept C2780365088 @default.
• W3217006454 hasConcept C2781421780 @default.
• W3217006454 hasConcept C41685203 @default.
• W3217006454 hasConcept C55493867 @default.
• W3217006454 hasConcept C70262065 @default.
• W3217006454 hasConcept C71924100 @default.
• W3217006454 hasConceptScore W3217006454C100544194 @default.
• W3217006454 hasConceptScore W3217006454C159110408 @default.
• W3217006454 hasConceptScore W3217006454C185592680 @default.
• W3217006454 hasConceptScore W3217006454C2776661111 @default.
• W3217006454 hasConceptScore W3217006454C2778439678 @default.
• W3217006454 hasConceptScore W3217006454C2779521917 @default.
• W3217006454 hasConceptScore W3217006454C2780116568 @default.
• W3217006454 hasConceptScore W3217006454C2780365088 @default.
• W3217006454 hasConceptScore W3217006454C2781421780 @default.
• W3217006454 hasConceptScore W3217006454C41685203 @default.
• W3217006454 hasConceptScore W3217006454C55493867 @default.
• W3217006454 hasConceptScore W3217006454C70262065 @default.
• W3217006454 hasConceptScore W3217006454C71924100 @default.
• W3217006454 hasLocation W32170064541 @default.
• W3217006454 hasLocation W32170064542 @default.
• W3217006454 hasOpenAccess W3217006454 @default.

• next