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• W3217014685 endingPage "127915" @default.
• W3217014685 startingPage "127915" @default.
• W3217014685 abstract "The present report compares the antibacterial properties of unique (sphere+rod)-shaped gold nanostar with its structural components, i.e., gold nanorods and nanosphere. Gold nanostars, nanorods, and nanospheres have been synthesized using literature reported protocols. Clinical isolates of gram-negative E. coli and gram-positive S. aureus bacteria have been used as model pathogens for the antibacterial studies. The antibacterial activities of the nanoparticles have been assessed using various techniques. To compare the antimicrobial activity of the nanoparticles, we have investigated the effects of varying gold concentrations of different nanoparticles on bacterial growth kinetics. The impacts of the leached/residual gold ions and the surface capping agent and charge of the particles on the antibacterial activity have also been assessed. Studies of the nanoparticle’s dose and exposure time show the highest antibacterial activity for nanostars and lowest for nanospheres for a given quantity of gold. Bradford’s Reagent Assay and confocal fluorescent microscopy studies confirm the trend of the particle-specific antibacterial activities. SEM/TEM and DNA extraction studies show that the bactericidal activities involve a combination of effects like the destruction of cell membrane, fragmentation of bacterial DNA, internalization of particles, etc. To assess the antibacterial impacts of the amount of leached/residual gold ions, their concentrations have been determined by inductively coupled plasma - optical emission (ICP-OES) and mass (ICP-MS) spectroscopic studies as well as the effects of the added gold ions have been studied. No discernible effects have been observed due to the variation in the leached/residual gold ions amount. The DCHF-DA fluorescence assay has been employed to determine the levels of reactive oxygen species (ROS) produced by different nanoparticle systems, which corresponds to the trend in antibacterial activities observed. The nature and magnitude of the surface charge have been determined by zeta potential measurements. Analyses of the impacts of various parameters/factors like gold ions, capping agents, surface charges, ROS levels, etc., show that the antibacterial activities of the gold nanoparticles of different morphology arise from both morphology-specific physical and chemical effects of the gold nanoparticles. • Antibacterial activities of (sphere+rod)-shaped gold nanostars have been compared with nanorods and nanospheres. • Model pathogens studied clinical isolates of gram-negative E. coli and gram-positive S. aureus bacteria. • Anisotropic particles show higher antibacterial effects for a given amount of gold. • Antibacterial effects of particle morphology are more than the global effects. • Particle morphology effects involve particle-specific geometry, surface charge, and ROS produced." @default.
• W3217014685 created "2021-12-06" @default.
• W3217014685 creator A5006735219 @default.
• W3217014685 creator A5029832840 @default.
• W3217014685 creator A5054041329 @default.
• W3217014685 creator A5076903877 @default.
• W3217014685 creator A5090088155 @default.
• W3217014685 date "2022-02-01" @default.
• W3217014685 modified "2023-10-01" @default.
• W3217014685 title "Particle specific physical and chemical effects on antibacterial activities: A comparative study involving gold nanostars, nanorods and nanospheres" @default.
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