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- W3217022023 abstract "Several quantitive studies were done to test hypothesis based on qualitative observations that thymocytes increase the rate of growth of transplanted bone marrow cells. Hemopoietic colonies on the surface of spleens of irradiated (900 R) F/sub 1/ hybrid recipients were measured 10 or 11 days after transplantation of parental marrow cells with or without thymocytes. Cross-sectional areas of erythropoietic and granulopoietic colonies were calculated from microscopic measurements made on histologic preparations of spleens taken 8 to 11 days after transplantation. Burst size of splenic colonies was estimated from in vivo /sup 3/H-dT uptake values and of erythropoietic colonies from 6-hour /sup 59/Fe uptake values. Kinetics studies included daily assessment of (a) erythropoiesis in groups of Xenogeneic chimeras and (b) in vitro /sup 3/H-dT incorporation by suspensions of chimeric spleen cells. Results of these studies confirm our earlier deduction, from histologic observations, that thymocytes augment the initial take and the rate of proliferation of transplanted hemopoietic tissue. Thus thymocytes can be regarded as amplifier cells." @default.
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- W3217022023 date "1978-01-01" @default.
- W3217022023 modified "2023-09-24" @default.
- W3217022023 title "Amplifier cell in hemopoiesis" @default.
- W3217022023 hasPublicationYear "1978" @default.
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