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• W3217029703 abstract "<b>Background:</b> Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease, leading cause of high mortality and morbidity worldwide. Data suggest that roflumilast reduces moderate to severe exacerbations most well in severe disease. <b>Aim:</b> To investigate the levels of CRP and collagen IV in bronchoalveolar fluid (BALF) in patients with COPD GOLD III. <b>Methods:</b> The levels of CRP and collagen IV were studied in 61 patients in BALF using ELISA in patients with severe COPD before and after 180 days of maintenance treatment with roflumilast.  There were 15 AHI. Roflumilast was administered orally once daily in the morning at one dose level – 500 mcg. <b>Results:</b> Before treatment the CRP levels were increased in 4.7 times (p<0.05) compared to the AHI. This rate in GOLD group D was in 2.7 times higher (p<0.05) than in GOLD group C. After 180 days treatment without roflumilast the positive dynamics of CRP level was not achieved. CRP level at the end of treatment with roflumilast was (4,1±0,3) mg/L and it was in 1.5 times lower compared with the data before treatment, but still remained in 2.5 times higher compared the rate of the AHI group. It was a significant decrease in the level of collagen IV of the 6-month follow-up dynamics under the influence of treatment with roflumilast. This indicator has decreased in the process of therapy in 3,54 times (p1<0,05). <b>Conclusions:</b> Inclusion of roflumilast in the complex of pharmacological therapy provided positive dynamics of collagen IV and CRP level concentration." @default.
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• W3217029703 date "2021-09-05" @default.
• W3217029703 modified "2023-09-30" @default.
• W3217029703 title "C-reactive protein and the type IV collagen measurementin severe COPD: Value of roflumilast" @default.
• W3217029703 doi "https://doi.org/10.1183/13993003.congress-2021.pa556" @default.
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